Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections
The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. Those most in need are typically high-risk and include individual...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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MDPI
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/109133/ |
| _version_ | 1848865291491082240 |
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| author | Atshan, Salman Sahab Hamat, Rukman Awang Aljaberi, Musheer A. Chen, Jung Sheng Huang, Shih Wei Lin, Chung Ying Mullins, Benjamin J. Kicic, Anthony |
| author_facet | Atshan, Salman Sahab Hamat, Rukman Awang Aljaberi, Musheer A. Chen, Jung Sheng Huang, Shih Wei Lin, Chung Ying Mullins, Benjamin J. Kicic, Anthony |
| author_sort | Atshan, Salman Sahab |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. Those most in need are typically high-risk and include individuals who experience burns and other wounds, as well as those with pulmonary infections caused by antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter sp, and Staphylococci. With investment to develop new antibiotics waning, finding and developing alternative therapeutic strategies to tackle this issue is imperative. One option remerging in popularity is bacteriophage (phage) therapy. This review focuses on Staphylococcus aureus and how it has developed resistance to antibiotics. It also discusses the potential of phage therapy in this setting and its appropriateness in high-risk people, such as those with cystic fibrosis, where it typically forms a biofilm. |
| first_indexed | 2025-11-15T14:02:22Z |
| format | Article |
| id | upm-109133 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:02:22Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1091332024-10-14T07:50:38Z http://psasir.upm.edu.my/id/eprint/109133/ Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections Atshan, Salman Sahab Hamat, Rukman Awang Aljaberi, Musheer A. Chen, Jung Sheng Huang, Shih Wei Lin, Chung Ying Mullins, Benjamin J. Kicic, Anthony The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. Those most in need are typically high-risk and include individuals who experience burns and other wounds, as well as those with pulmonary infections caused by antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter sp, and Staphylococci. With investment to develop new antibiotics waning, finding and developing alternative therapeutic strategies to tackle this issue is imperative. One option remerging in popularity is bacteriophage (phage) therapy. This review focuses on Staphylococcus aureus and how it has developed resistance to antibiotics. It also discusses the potential of phage therapy in this setting and its appropriateness in high-risk people, such as those with cystic fibrosis, where it typically forms a biofilm. MDPI 2023 Article PeerReviewed Atshan, Salman Sahab and Hamat, Rukman Awang and Aljaberi, Musheer A. and Chen, Jung Sheng and Huang, Shih Wei and Lin, Chung Ying and Mullins, Benjamin J. and Kicic, Anthony (2023) Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections. Antibiotics, 12 (2). art. no. 286. pp. 1-23. ISSN 2079-6382 https://doi.org/10.3390/antibiotics12020286 10.3390/antibiotics12020286 |
| spellingShingle | Atshan, Salman Sahab Hamat, Rukman Awang Aljaberi, Musheer A. Chen, Jung Sheng Huang, Shih Wei Lin, Chung Ying Mullins, Benjamin J. Kicic, Anthony Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title | Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title_full | Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title_fullStr | Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title_full_unstemmed | Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title_short | Phage therapy as an alternative treatment modality for resistant Staphylococcus aureus infections |
| title_sort | phage therapy as an alternative treatment modality for resistant staphylococcus aureus infections |
| url | http://psasir.upm.edu.my/id/eprint/109133/ http://psasir.upm.edu.my/id/eprint/109133/ http://psasir.upm.edu.my/id/eprint/109133/ |