Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity and mortality caused by CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH oxidase (NOX)-derived...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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MDPI
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/109100/ |
| _version_ | 1848865283862691840 |
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| author | M. Sofiullah, Siti Sarah Murugan, Dharmani Devi Abd Muid, Suhaila Wu, Yuan Seng Syed Abdul Kadir, Sharifah Zamiah Abas, Razif Adib Ridzuan, Nurul Raudzah Zamakshshari, Nor Hisam Choy, Ker Woon |
| author_facet | M. Sofiullah, Siti Sarah Murugan, Dharmani Devi Abd Muid, Suhaila Wu, Yuan Seng Syed Abdul Kadir, Sharifah Zamiah Abas, Razif Adib Ridzuan, Nurul Raudzah Zamakshshari, Nor Hisam Choy, Ker Woon |
| author_sort | M. Sofiullah, Siti Sarah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed
and developing countries. According to the WHO report, the morbidity and mortality caused by
CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH
oxidase (NOX)-derived reactive oxygen species (ROS) production induces endothelial nitric oxide
synthase (eNOS) uncoupling and mitochondrial dysfunction, resulting in sustained oxidative stress
and the development of cardiovascular diseases. Seven distinct members of the family have been
identified of which four (namely, NOX1, 2, 4 and 5) may have cardiovascular functions. Currently,
the treatment and management plan for patients with CVDs mainly depends on the drugs. However,
prolonged use of prescribed drugs may cause adverse drug reactions. Therefore, it is crucial to find
alternative treatment options with lesser adverse effects. Natural products have been gaining interest
as complementary therapy for CVDs over the past decade due to their wide range of medicinal
properties, including antioxidants. These might be due to their potent active ingredients, such as
flavonoid and phenolic compounds. Numerous natural compounds have been demonstrated to have
advantageous effects on cardiovascular disease via NADPH cascade. This review highlights the
potential of natural products targeting NOX-derived ROS generation in treating CVDs. Emphasis is
put on the activation of the oxidases, including upstream or downstream signalling events. |
| first_indexed | 2025-11-15T14:02:15Z |
| format | Article |
| id | upm-109100 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:02:15Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1091002024-10-14T03:40:36Z http://psasir.upm.edu.my/id/eprint/109100/ Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases M. Sofiullah, Siti Sarah Murugan, Dharmani Devi Abd Muid, Suhaila Wu, Yuan Seng Syed Abdul Kadir, Sharifah Zamiah Abas, Razif Adib Ridzuan, Nurul Raudzah Zamakshshari, Nor Hisam Choy, Ker Woon Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed and developing countries. According to the WHO report, the morbidity and mortality caused by CVD will continue to rise with the estimation of death going up to 22.2 million in 2030. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) production induces endothelial nitric oxide synthase (eNOS) uncoupling and mitochondrial dysfunction, resulting in sustained oxidative stress and the development of cardiovascular diseases. Seven distinct members of the family have been identified of which four (namely, NOX1, 2, 4 and 5) may have cardiovascular functions. Currently, the treatment and management plan for patients with CVDs mainly depends on the drugs. However, prolonged use of prescribed drugs may cause adverse drug reactions. Therefore, it is crucial to find alternative treatment options with lesser adverse effects. Natural products have been gaining interest as complementary therapy for CVDs over the past decade due to their wide range of medicinal properties, including antioxidants. These might be due to their potent active ingredients, such as flavonoid and phenolic compounds. Numerous natural compounds have been demonstrated to have advantageous effects on cardiovascular disease via NADPH cascade. This review highlights the potential of natural products targeting NOX-derived ROS generation in treating CVDs. Emphasis is put on the activation of the oxidases, including upstream or downstream signalling events. MDPI 2023-01-20 Article PeerReviewed M. Sofiullah, Siti Sarah and Murugan, Dharmani Devi and Abd Muid, Suhaila and Wu, Yuan Seng and Syed Abdul Kadir, Sharifah Zamiah and Abas, Razif and Adib Ridzuan, Nurul Raudzah and Zamakshshari, Nor Hisam and Choy, Ker Woon (2023) Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases. Molecules, 28 (3). art. no. 1047. pp. 1-24. ISSN 1420-3049 https://www.mdpi.com/1420-3049/28/3/1047 10.3390/molecules28031047 |
| spellingShingle | M. Sofiullah, Siti Sarah Murugan, Dharmani Devi Abd Muid, Suhaila Wu, Yuan Seng Syed Abdul Kadir, Sharifah Zamiah Abas, Razif Adib Ridzuan, Nurul Raudzah Zamakshshari, Nor Hisam Choy, Ker Woon Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title | Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title_full | Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title_fullStr | Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title_full_unstemmed | Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title_short | Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases |
| title_sort | natural bioactive compounds targeting nadph oxidase pathway in cardiovascular diseases |
| url | http://psasir.upm.edu.my/id/eprint/109100/ http://psasir.upm.edu.my/id/eprint/109100/ http://psasir.upm.edu.my/id/eprint/109100/ |