Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective
The aging population increases steadily because of a healthy lifestyle and medical advancements in healthcare. However, Alzheimer’s disease (AD) is becoming more common and problematic among older adults. AD-related cases show an increasing trend annually, and the younger age population may also be...
| Main Authors: | , , , , , |
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| Format: | Article |
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IOS Press
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108863/ |
| _version_ | 1848865223530774528 |
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| author | Rajah Kumaran, Kesevan Yunusa, Suleiman Perimal, Enoch Wahab, Habibah Müller, Christian P. Hassan, Zurina |
| author_facet | Rajah Kumaran, Kesevan Yunusa, Suleiman Perimal, Enoch Wahab, Habibah Müller, Christian P. Hassan, Zurina |
| author_sort | Rajah Kumaran, Kesevan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The aging population increases steadily because of a healthy lifestyle and medical advancements in healthcare. However, Alzheimer’s disease (AD) is becoming more common and problematic among older adults. AD-related cases show an increasing trend annually, and the younger age population may also be at risk of developing this disorder. AD constitutes a primary form of dementia, an irreversible and progressive brain disorder that steadily damages cognitive functions and the ability to perform daily tasks. Later in life, AD leads to death as a result of the degeneration of specific brain areas. Currently, the cause of AD is poorly understood, and there is no safe and effective therapeutic agent to cure or slow down its progression. The condition is entirely preventable, and no study has yet demonstrated encouraging findings in terms of treatment. Identifying this disease’s pathophysiology can help researchers develop safe and efficient therapeutic strategies to treat this ailment. This review outlines and discusses the pathophysiology that resulted in the development of AD including amyloid-β plaques, tau neurofibrillary tangles, neuroinflammation, oxidative stress, cholinergic dysfunction, glutamate excitotoxicity, and changes in neurotrophins levels based on the literature search from Scopus, PubMed, ScienceDirect, and Google Scholar. Potential therapeutic strategies are discussed to provide more insights into AD mechanisms by developing some possible pharmacological agents for its treatment. |
| first_indexed | 2025-11-15T14:01:18Z |
| format | Article |
| id | upm-108863 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:01:18Z |
| publishDate | 2023 |
| publisher | IOS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1088632024-09-26T08:31:47Z http://psasir.upm.edu.my/id/eprint/108863/ Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective Rajah Kumaran, Kesevan Yunusa, Suleiman Perimal, Enoch Wahab, Habibah Müller, Christian P. Hassan, Zurina The aging population increases steadily because of a healthy lifestyle and medical advancements in healthcare. However, Alzheimer’s disease (AD) is becoming more common and problematic among older adults. AD-related cases show an increasing trend annually, and the younger age population may also be at risk of developing this disorder. AD constitutes a primary form of dementia, an irreversible and progressive brain disorder that steadily damages cognitive functions and the ability to perform daily tasks. Later in life, AD leads to death as a result of the degeneration of specific brain areas. Currently, the cause of AD is poorly understood, and there is no safe and effective therapeutic agent to cure or slow down its progression. The condition is entirely preventable, and no study has yet demonstrated encouraging findings in terms of treatment. Identifying this disease’s pathophysiology can help researchers develop safe and efficient therapeutic strategies to treat this ailment. This review outlines and discusses the pathophysiology that resulted in the development of AD including amyloid-β plaques, tau neurofibrillary tangles, neuroinflammation, oxidative stress, cholinergic dysfunction, glutamate excitotoxicity, and changes in neurotrophins levels based on the literature search from Scopus, PubMed, ScienceDirect, and Google Scholar. Potential therapeutic strategies are discussed to provide more insights into AD mechanisms by developing some possible pharmacological agents for its treatment. IOS Press 2023-01-17 Article PeerReviewed Rajah Kumaran, Kesevan and Yunusa, Suleiman and Perimal, Enoch and Wahab, Habibah and Müller, Christian P. and Hassan, Zurina (2023) Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective. Journal of Alzheimer's Disease, 91 (2). pp. 507-530. ISSN 1387-2877; ESSN: 1875-8908 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220666 10.3233/jad-220666 |
| spellingShingle | Rajah Kumaran, Kesevan Yunusa, Suleiman Perimal, Enoch Wahab, Habibah Müller, Christian P. Hassan, Zurina Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title | Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title_full | Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title_fullStr | Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title_full_unstemmed | Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title_short | Insights into the pathophysiology of Alzheimers disease and potential therapeutic targets: a current perspective |
| title_sort | insights into the pathophysiology of alzheimers disease and potential therapeutic targets: a current perspective |
| url | http://psasir.upm.edu.my/id/eprint/108863/ http://psasir.upm.edu.my/id/eprint/108863/ http://psasir.upm.edu.my/id/eprint/108863/ |