Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota
Obesity has been reported to be associated with dysbiosis of gut microbiota. Sciadonic acid (SC) is one of the main functional components of Torreya grandis “Merrillii” seed oil. However, the effect of SC on high-fat diet (HFD)-induced obesity has not been elucidated. In this study, we evaluated the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Royal Society of Chemistry (RSC)
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108846/ |
| _version_ | 1848865219610148864 |
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| author | Chen, Lin Jiang, Qihong Jiang, Chenkai Lu, Hongling Hu, Wenjun Yu, Shaofang Li, Mingqian Tan, Chin Ping Feng, Yongcai Xiang, Xingwei Shen, Guoxin |
| author_facet | Chen, Lin Jiang, Qihong Jiang, Chenkai Lu, Hongling Hu, Wenjun Yu, Shaofang Li, Mingqian Tan, Chin Ping Feng, Yongcai Xiang, Xingwei Shen, Guoxin |
| author_sort | Chen, Lin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Obesity has been reported to be associated with dysbiosis of gut microbiota. Sciadonic acid (SC) is one of the main functional components of Torreya grandis “Merrillii” seed oil. However, the effect of SC on high-fat diet (HFD)-induced obesity has not been elucidated. In this study, we evaluated the effects of SC on lipid metabolism and the gut flora in mice fed with a high-fat diet. The results revealed that SC activates the PPARα/SREBP-1C/FAS signaling pathway and reduces the levels of total cholesterol (TC), triacylglycerols (TG), and low-density lipoprotein cholesterol (LDL-C), but increases the level of high-density lipoprotein cholesterol (HDL-C) and inhibits weight gain. Among them, high-dose SC was the most effective; the TC, TG and LDL-C levels were reduced by 20.03%, 28.40% and 22.07%, respectively; the HDL-C level was increased by 8.55%. In addition, SC significantly increased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels by 98.21% and 35.17%, respectively, decreased oxidative stress, and ameliorated the pathological damage to the liver caused by a high-fat diet. Furthermore, SC treatment altered the composition of the intestinal flora, promoting the relative abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium, while simultaneously decreasing the relative abundance of potentially harmful bacteria such as Faecalibaculum, norank_f_Desulfovibrionaceae, and Romboutsia. Spearman's correlation analysis indicated that the gut microbiota was associated with SCFAs and biochemical indicators. In summary, our results suggested that SC can improve lipid metabolism disorders and regulate the gut microbial structure. |
| first_indexed | 2025-11-15T14:01:14Z |
| format | Article |
| id | upm-108846 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:01:14Z |
| publishDate | 2023 |
| publisher | Royal Society of Chemistry (RSC) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1088462024-10-11T07:26:53Z http://psasir.upm.edu.my/id/eprint/108846/ Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota Chen, Lin Jiang, Qihong Jiang, Chenkai Lu, Hongling Hu, Wenjun Yu, Shaofang Li, Mingqian Tan, Chin Ping Feng, Yongcai Xiang, Xingwei Shen, Guoxin Obesity has been reported to be associated with dysbiosis of gut microbiota. Sciadonic acid (SC) is one of the main functional components of Torreya grandis “Merrillii” seed oil. However, the effect of SC on high-fat diet (HFD)-induced obesity has not been elucidated. In this study, we evaluated the effects of SC on lipid metabolism and the gut flora in mice fed with a high-fat diet. The results revealed that SC activates the PPARα/SREBP-1C/FAS signaling pathway and reduces the levels of total cholesterol (TC), triacylglycerols (TG), and low-density lipoprotein cholesterol (LDL-C), but increases the level of high-density lipoprotein cholesterol (HDL-C) and inhibits weight gain. Among them, high-dose SC was the most effective; the TC, TG and LDL-C levels were reduced by 20.03%, 28.40% and 22.07%, respectively; the HDL-C level was increased by 8.55%. In addition, SC significantly increased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels by 98.21% and 35.17%, respectively, decreased oxidative stress, and ameliorated the pathological damage to the liver caused by a high-fat diet. Furthermore, SC treatment altered the composition of the intestinal flora, promoting the relative abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium, while simultaneously decreasing the relative abundance of potentially harmful bacteria such as Faecalibaculum, norank_f_Desulfovibrionaceae, and Romboutsia. Spearman's correlation analysis indicated that the gut microbiota was associated with SCFAs and biochemical indicators. In summary, our results suggested that SC can improve lipid metabolism disorders and regulate the gut microbial structure. Royal Society of Chemistry (RSC) 2023-02-14 Article PeerReviewed Chen, Lin and Jiang, Qihong and Jiang, Chenkai and Lu, Hongling and Hu, Wenjun and Yu, Shaofang and Li, Mingqian and Tan, Chin Ping and Feng, Yongcai and Xiang, Xingwei and Shen, Guoxin (2023) Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota. Food & Function, 14 (6). 2870- 2880. ISSN 2042-6496; ESSN: 2042-650X https://pubs.rsc.org/en/content/articlelanding/2023/fo/d2fo02524h 10.1039/d2fo02524h |
| spellingShingle | Chen, Lin Jiang, Qihong Jiang, Chenkai Lu, Hongling Hu, Wenjun Yu, Shaofang Li, Mingqian Tan, Chin Ping Feng, Yongcai Xiang, Xingwei Shen, Guoxin Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title | Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title_full | Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title_fullStr | Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title_full_unstemmed | Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title_short | Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| title_sort | sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota |
| url | http://psasir.upm.edu.my/id/eprint/108846/ http://psasir.upm.edu.my/id/eprint/108846/ http://psasir.upm.edu.my/id/eprint/108846/ |