Serum separation abnormality in a multiple myeloma patient
Introduction: M-protein secreted by myeloma cells do not only contribute to myeloma-related complications but is also a well-recognised source of interference in laboratory assays. We describe a case of a 62-year-old woman whose blood sample showed improper serum separation even after resampling. Ca...
| Main Authors: | , , , |
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| Format: | Article |
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Malaysian Society of Pathologists
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108803/ |
| _version_ | 1848865211033845760 |
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| author | Zaharudin, Mohd Radzli Thambiah, Subashini C. Samsudin, Intan Nureslyna A. Hamid, Hanisah |
| author_facet | Zaharudin, Mohd Radzli Thambiah, Subashini C. Samsudin, Intan Nureslyna A. Hamid, Hanisah |
| author_sort | Zaharudin, Mohd Radzli |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: M-protein secreted by myeloma cells do not only contribute to myeloma-related complications but is also a well-recognised source of interference in laboratory assays. We describe a case of a 62-year-old woman whose blood sample showed improper serum separation even after resampling. Case report: Centrifugation of a biochemistry specimen in a serum-separator tube received by the laboratory failed to separate any serum, nor did repeating the process at a longer duration. Repeat sampling only yielded a small volume of serum from which highly elevated total protein was noted upon analysis. Additional history from the treating clinician unveiled a diagnosis of multiple myeloma in this patient. Discussion: This case represents one of the rare, but significant pre-analytical interferences caused by M-proteins. |
| first_indexed | 2025-11-15T14:01:06Z |
| format | Article |
| id | upm-108803 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:01:06Z |
| publishDate | 2023 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1088032024-10-03T04:22:54Z http://psasir.upm.edu.my/id/eprint/108803/ Serum separation abnormality in a multiple myeloma patient Zaharudin, Mohd Radzli Thambiah, Subashini C. Samsudin, Intan Nureslyna A. Hamid, Hanisah Introduction: M-protein secreted by myeloma cells do not only contribute to myeloma-related complications but is also a well-recognised source of interference in laboratory assays. We describe a case of a 62-year-old woman whose blood sample showed improper serum separation even after resampling. Case report: Centrifugation of a biochemistry specimen in a serum-separator tube received by the laboratory failed to separate any serum, nor did repeating the process at a longer duration. Repeat sampling only yielded a small volume of serum from which highly elevated total protein was noted upon analysis. Additional history from the treating clinician unveiled a diagnosis of multiple myeloma in this patient. Discussion: This case represents one of the rare, but significant pre-analytical interferences caused by M-proteins. Malaysian Society of Pathologists 2023 Article PeerReviewed Zaharudin, Mohd Radzli and Thambiah, Subashini C. and Samsudin, Intan Nureslyna and A. Hamid, Hanisah (2023) Serum separation abnormality in a multiple myeloma patient. Malaysian Journal of Pathology, 45 (1). pp. 123-127. ISSN 0126-8635 https://www.mjpath.org.my/2023/v45n1/index.php |
| spellingShingle | Zaharudin, Mohd Radzli Thambiah, Subashini C. Samsudin, Intan Nureslyna A. Hamid, Hanisah Serum separation abnormality in a multiple myeloma patient |
| title | Serum separation abnormality in a multiple myeloma patient |
| title_full | Serum separation abnormality in a multiple myeloma patient |
| title_fullStr | Serum separation abnormality in a multiple myeloma patient |
| title_full_unstemmed | Serum separation abnormality in a multiple myeloma patient |
| title_short | Serum separation abnormality in a multiple myeloma patient |
| title_sort | serum separation abnormality in a multiple myeloma patient |
| url | http://psasir.upm.edu.my/id/eprint/108803/ http://psasir.upm.edu.my/id/eprint/108803/ |