Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties
The incorporation of antimicrobial peptides (AMPs) in graphene-based materials is a growing strategy to overcome the shortcomings presented by conventional antimicrobial nanomaterials derived from metal/metal oxide. In this study, novel cyclic undecapeptides CH1 and CW2 (KRQRFYFRQRK and QNKRFYFRKNQ,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Springer
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108755/ |
| _version_ | 1848865203260751872 |
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| author | Farrag, H. N. Zheng, A. L. T. Sabidi, S. Wu, Y. Ikeno, S. Maeda, T. Andou, Y. Kato, T. |
| author_facet | Farrag, H. N. Zheng, A. L. T. Sabidi, S. Wu, Y. Ikeno, S. Maeda, T. Andou, Y. Kato, T. |
| author_sort | Farrag, H. N. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The incorporation of antimicrobial peptides (AMPs) in graphene-based materials is a growing strategy to overcome the shortcomings presented by conventional antimicrobial nanomaterials derived from metal/metal oxide. In this study, novel cyclic undecapeptides CH1 and CW2 (KRQRFYFRQRK and QNKRFYFRKNQ, respectively) were successfully synthesized. The cyclic peptides were then immobilized on the reduced graphene oxide (rGO) surface using a water-soluble carbodiimide (EDCI/HCl) linker. The structural, morphology, and chemical characterizations of the antimicrobial graphene material were carried out using SEM, Raman, FTIR, XRD, and XPS. From our result, the peptide/rGO composite showed an improved antibacterial effect towards gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa). The enhanced antibacterial property is attributed to the synergistic effect of the sharp edges of rGO and the amphipathic moieties of the cyclic peptides. |
| first_indexed | 2025-11-15T14:00:58Z |
| format | Article |
| id | upm-108755 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:00:58Z |
| publishDate | 2023 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1087552024-10-11T07:24:15Z http://psasir.upm.edu.my/id/eprint/108755/ Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties Farrag, H. N. Zheng, A. L. T. Sabidi, S. Wu, Y. Ikeno, S. Maeda, T. Andou, Y. Kato, T. The incorporation of antimicrobial peptides (AMPs) in graphene-based materials is a growing strategy to overcome the shortcomings presented by conventional antimicrobial nanomaterials derived from metal/metal oxide. In this study, novel cyclic undecapeptides CH1 and CW2 (KRQRFYFRQRK and QNKRFYFRKNQ, respectively) were successfully synthesized. The cyclic peptides were then immobilized on the reduced graphene oxide (rGO) surface using a water-soluble carbodiimide (EDCI/HCl) linker. The structural, morphology, and chemical characterizations of the antimicrobial graphene material were carried out using SEM, Raman, FTIR, XRD, and XPS. From our result, the peptide/rGO composite showed an improved antibacterial effect towards gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa). The enhanced antibacterial property is attributed to the synergistic effect of the sharp edges of rGO and the amphipathic moieties of the cyclic peptides. Springer 2023-06-17 Article PeerReviewed Farrag, H. N. and Zheng, A. L. T. and Sabidi, S. and Wu, Y. and Ikeno, S. and Maeda, T. and Andou, Y. and Kato, T. (2023) Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties. International Journal of Environmental Science and Technology, 21 (2). pp. 1481-1492. ISSN 1735-1472; ESSN: 1735-2630 https://link.springer.com/article/10.1007/s13762-023-05035-z?error=cookies_not_supported&code=8b889563-2e5e-4203-948e-f3177c46b5b4 10.1007/s13762-023-05035-z |
| spellingShingle | Farrag, H. N. Zheng, A. L. T. Sabidi, S. Wu, Y. Ikeno, S. Maeda, T. Andou, Y. Kato, T. Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title | Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title_full | Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title_fullStr | Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title_full_unstemmed | Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title_short | Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| title_sort | novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties |
| url | http://psasir.upm.edu.my/id/eprint/108755/ http://psasir.upm.edu.my/id/eprint/108755/ http://psasir.upm.edu.my/id/eprint/108755/ |