Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Taylor and Francis Group
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108720/ |
| _version_ | 1848865197827031040 |
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| author | Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa |
| author_facet | Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa |
| author_sort | Baharuddin, Fatin Farhana |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry. |
| first_indexed | 2025-11-15T14:00:53Z |
| format | Article |
| id | upm-108720 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:00:53Z |
| publishDate | 2023 |
| publisher | Taylor and Francis Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1087202024-10-11T08:24:23Z http://psasir.upm.edu.my/id/eprint/108720/ Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry. Taylor and Francis Group 2023-10-05 Article PeerReviewed Baharuddin, Fatin Farhana and Mad Nasir, Nadiah and Tejo, Bimo Ario and Koh, Soo Peng and Ramakrishnan, Shuruti and Nordin, Nur Qurratu Ain A. and Adzahar, Anis Nasuha and Devakrishnan, Pavithren and Mohd Razib, Salsabiilaa (2023) Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity. Journal of Asian Natural Products Research, 26 (5). pp. 575-582. ISSN 1028-6020; ESSN: 1477-2213 https://www.tandfonline.com/doi/full/10.1080/10286020.2023.2264784 10.1080/10286020.2023.2264784 |
| spellingShingle | Baharuddin, Fatin Farhana Mad Nasir, Nadiah Tejo, Bimo Ario Koh, Soo Peng Ramakrishnan, Shuruti Nordin, Nur Qurratu Ain A. Adzahar, Anis Nasuha Devakrishnan, Pavithren Mohd Razib, Salsabiilaa Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title | Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title_full | Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title_fullStr | Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title_full_unstemmed | Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title_short | Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| title_sort | potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity |
| url | http://psasir.upm.edu.my/id/eprint/108720/ http://psasir.upm.edu.my/id/eprint/108720/ http://psasir.upm.edu.my/id/eprint/108720/ |