The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection
In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSV...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108690/ http://psasir.upm.edu.my/id/eprint/108690/1/The%20NLRP3%20inflammasome%20in%20age-related%20cerebral.pdf |
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| author | Che Mohd Nassir, Che Mohd Nasril Damodaran, Thenmoly Ismail, Nurul Iman Hashim, Sabarisah Jaffer, Usman Hamid, Hafizah Abdul Mehat, Muhammad Zulfadli Norazit, Anwar Mustapha, Muzaimi |
| author_facet | Che Mohd Nassir, Che Mohd Nasril Damodaran, Thenmoly Ismail, Nurul Iman Hashim, Sabarisah Jaffer, Usman Hamid, Hafizah Abdul Mehat, Muhammad Zulfadli Norazit, Anwar Mustapha, Muzaimi |
| author_sort | Che Mohd Nassir, Che Mohd Nasril |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD). Although NLRP3 inflammasome-interleukin (IL)-1β has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. Here, we elaborate on the current manifestations of CSVD and its’ complex pathogenesis and relate the array of activators and aberrant activation involving NLRP3 inflammasome with this condition. These neuroinflammatory insights would expand on our current understanding of CSVD clinical (and subclinical) heterogenous manifestations whilst highlighting plausible NLRP3-linked therapeutic targets. |
| first_indexed | 2025-11-15T14:00:49Z |
| format | Article |
| id | upm-108690 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T14:00:49Z |
| publishDate | 2023 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1086902024-10-11T08:37:32Z http://psasir.upm.edu.my/id/eprint/108690/ The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection Che Mohd Nassir, Che Mohd Nasril Damodaran, Thenmoly Ismail, Nurul Iman Hashim, Sabarisah Jaffer, Usman Hamid, Hafizah Abdul Mehat, Muhammad Zulfadli Norazit, Anwar Mustapha, Muzaimi In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD). Although NLRP3 inflammasome-interleukin (IL)-1β has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. Here, we elaborate on the current manifestations of CSVD and its’ complex pathogenesis and relate the array of activators and aberrant activation involving NLRP3 inflammasome with this condition. These neuroinflammatory insights would expand on our current understanding of CSVD clinical (and subclinical) heterogenous manifestations whilst highlighting plausible NLRP3-linked therapeutic targets. Multidisciplinary Digital Publishing Institute 2023-01-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/108690/1/The%20NLRP3%20inflammasome%20in%20age-related%20cerebral.pdf Che Mohd Nassir, Che Mohd Nasril and Damodaran, Thenmoly and Ismail, Nurul Iman and Hashim, Sabarisah and Jaffer, Usman and Hamid, Hafizah Abdul and Mehat, Muhammad Zulfadli and Norazit, Anwar and Mustapha, Muzaimi (2023) The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection. Life, 13 (1). art. no. 216. pp. 1-17. ISSN 2075-1729 https://www.mdpi.com/2075-1729/13/1/216 10.3390/life13010216 |
| spellingShingle | Che Mohd Nassir, Che Mohd Nasril Damodaran, Thenmoly Ismail, Nurul Iman Hashim, Sabarisah Jaffer, Usman Hamid, Hafizah Abdul Mehat, Muhammad Zulfadli Norazit, Anwar Mustapha, Muzaimi The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title | The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title_full | The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title_fullStr | The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title_full_unstemmed | The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title_short | The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| title_sort | nlrp3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection |
| url | http://psasir.upm.edu.my/id/eprint/108690/ http://psasir.upm.edu.my/id/eprint/108690/ http://psasir.upm.edu.my/id/eprint/108690/ http://psasir.upm.edu.my/id/eprint/108690/1/The%20NLRP3%20inflammasome%20in%20age-related%20cerebral.pdf |