Mitochondria dysfunction and bipolar disorder: from pathology to therapy
Bipolar disorder (BD) is one of the major psychiatric diseases in which the impairment of mitochondrial functions has been closely connected or associated with the disease pathologies. Different lines of evidence of the close connection between mitochondria dysfunction and BD were discussed with a p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2023
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/108554/ |
| _version_ | 1848865171779354624 |
|---|---|
| author | Lam, Xin-Jieh Xu, Bingzhe Yeo, Pei-Ling Cheah, Pike-See Ling, King-Hwa |
| author_facet | Lam, Xin-Jieh Xu, Bingzhe Yeo, Pei-Ling Cheah, Pike-See Ling, King-Hwa |
| author_sort | Lam, Xin-Jieh |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Bipolar disorder (BD) is one of the major psychiatric diseases in which the impairment of mitochondrial functions has been closely connected or associated with the disease pathologies. Different lines of evidence of the close connection between mitochondria dysfunction and BD were discussed with a particular focus on (1) dysregulation of energy metabolism, (2) effect of genetic variants, (3) oxidative stress, cell death and apoptosis, (4) dysregulated calcium homeostasis and electrophysiology, and (5) current as well as potential treatments targeting at restoring mitochondrial functions. Currently, pharmacological interventions generally provide limited efficacy in preventing relapses or recovery from mania or depression episodes. Thus, understanding mitochondrial pathology in BD will lead to novel agents targeting mitochondrial dysfunction and formulating new effective therapy for BD. |
| first_indexed | 2025-11-15T14:00:28Z |
| format | Article |
| id | upm-108554 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:00:28Z |
| publishDate | 2023 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1085542024-10-03T04:24:10Z http://psasir.upm.edu.my/id/eprint/108554/ Mitochondria dysfunction and bipolar disorder: from pathology to therapy Lam, Xin-Jieh Xu, Bingzhe Yeo, Pei-Ling Cheah, Pike-See Ling, King-Hwa Bipolar disorder (BD) is one of the major psychiatric diseases in which the impairment of mitochondrial functions has been closely connected or associated with the disease pathologies. Different lines of evidence of the close connection between mitochondria dysfunction and BD were discussed with a particular focus on (1) dysregulation of energy metabolism, (2) effect of genetic variants, (3) oxidative stress, cell death and apoptosis, (4) dysregulated calcium homeostasis and electrophysiology, and (5) current as well as potential treatments targeting at restoring mitochondrial functions. Currently, pharmacological interventions generally provide limited efficacy in preventing relapses or recovery from mania or depression episodes. Thus, understanding mitochondrial pathology in BD will lead to novel agents targeting mitochondrial dysfunction and formulating new effective therapy for BD. Elsevier 2023 Article PeerReviewed Lam, Xin-Jieh and Xu, Bingzhe and Yeo, Pei-Ling and Cheah, Pike-See and Ling, King-Hwa (2023) Mitochondria dysfunction and bipolar disorder: from pathology to therapy. IBRO Neuroscience Reports, 14. pp. 407-418. ISSN 2667-2421 https://linkinghub.elsevier.com/retrieve/pii/S2667242123000337 10.1016/j.ibneur.2023.04.002 |
| spellingShingle | Lam, Xin-Jieh Xu, Bingzhe Yeo, Pei-Ling Cheah, Pike-See Ling, King-Hwa Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title | Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title_full | Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title_fullStr | Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title_full_unstemmed | Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title_short | Mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| title_sort | mitochondria dysfunction and bipolar disorder: from pathology to therapy |
| url | http://psasir.upm.edu.my/id/eprint/108554/ http://psasir.upm.edu.my/id/eprint/108554/ http://psasir.upm.edu.my/id/eprint/108554/ |