Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis
Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. <jats:italic>Calophyllum</jat...
| Main Authors: | , , , |
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| Format: | Article |
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Wiley
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/108395/ |
| _version_ | 1848865147193393152 |
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| author | Abang Heilman, Dayang Nurul Anisa Hui, Audrey Yong Chee Mian, Vivien Jong Yi Ahmad, Fasihuddin Badruddin |
| author_facet | Abang Heilman, Dayang Nurul Anisa Hui, Audrey Yong Chee Mian, Vivien Jong Yi Ahmad, Fasihuddin Badruddin |
| author_sort | Abang Heilman, Dayang Nurul Anisa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. <jats:italic>Calophyllum</jats:italic> species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti‐bacterial properties that are effective against plant pathogens, hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from <jats:italic>Calophyllum</jats:italic> and its anti‐bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their co‐cystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti‐bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti‐microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition. |
| first_indexed | 2025-11-15T14:00:05Z |
| format | Article |
| id | upm-108395 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T14:00:05Z |
| publishDate | 2023 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1083952024-10-14T02:33:08Z http://psasir.upm.edu.my/id/eprint/108395/ Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis Abang Heilman, Dayang Nurul Anisa Hui, Audrey Yong Chee Mian, Vivien Jong Yi Ahmad, Fasihuddin Badruddin Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern, driven a need to discover and evaluate novel anti‐bacterial agents. <jats:italic>Calophyllum</jats:italic> species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti‐bacterial properties that are effective against plant pathogens, hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from <jats:italic>Calophyllum</jats:italic> and its anti‐bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their co‐cystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti‐bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti‐microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition. Wiley 2023 Article PeerReviewed Abang Heilman, Dayang Nurul Anisa and Hui, Audrey Yong Chee and Mian, Vivien Jong Yi and Ahmad, Fasihuddin Badruddin (2023) Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis. ChemistrySelect, 8 (46). pp. 1-18. ISSN 2365-6549 https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202302737 10.1002/slct.202302737 |
| spellingShingle | Abang Heilman, Dayang Nurul Anisa Hui, Audrey Yong Chee Mian, Vivien Jong Yi Ahmad, Fasihuddin Badruddin Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title | Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title_full | Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title_fullStr | Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title_full_unstemmed | Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title_short | Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| title_sort | unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis |
| url | http://psasir.upm.edu.my/id/eprint/108395/ http://psasir.upm.edu.my/id/eprint/108395/ http://psasir.upm.edu.my/id/eprint/108395/ |