Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase
Toxoplasma gondii (T. gondii) is a parasite capable of residing in the brain of their host which influences behaviour changes due to alterations in the neurotransmitters. Consequently, dopamine receptors (DRD) and indoleamine 2, 3 dioxygenase (IDO) dysregulation facilitate the progression of behavio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/108329/ http://psasir.upm.edu.my/id/eprint/108329/3/108329.pdf |
| _version_ | 1848865133437124608 |
|---|---|
| author | Wana, Mohammed Nasiru Watanabe, Malaika Chiroma, Samaila Musa Unyah, Ngah Zasmy Basir, Rusliza Mohd Moklas, Mohamad Aris Abd Majid, Roslaini Abdullahi, Sharif Alhassan Nordin, Shariza |
| author_facet | Wana, Mohammed Nasiru Watanabe, Malaika Chiroma, Samaila Musa Unyah, Ngah Zasmy Basir, Rusliza Mohd Moklas, Mohamad Aris Abd Majid, Roslaini Abdullahi, Sharif Alhassan Nordin, Shariza |
| author_sort | Wana, Mohammed Nasiru |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Toxoplasma gondii (T. gondii) is a parasite capable of residing in the brain of their host which influences behaviour changes due to alterations in the neurotransmitters. Consequently, dopamine receptors (DRD) and indoleamine 2, 3 dioxygenase (IDO) dysregulation facilitate the progression of behaviour changes in a host as a response to infection. This study tested the effect of neurotransmitter changes as a result of T. gondii infection on rats cognitive impairment. The T. gondii strain of type I, II and III from Malaysia were previously identified by standard procedures. Sporulated oocysts each of type I, II and III were inoculated separately into three groups of Wistar rats (n = 9) respectively. Two separate control groups received either phosphate buffered saline (PBS) or MK-801 (dizocilpine). Behaviour changes were evaluated at nine weeks post infection in a square box, elevated plus maze and gene expression level of DRD and IDO compounds. The study revealed increased fatal feline attraction, reduced anxiety, decreased DRD and increased IDO gene expression in the T. gondii infected groups and MK-801 compared to the PBS control group. In conclusion, T. gondii infection alter the level of neurotransmitters in rat which cause cognitive impairment. This implies that all the T. gondii strain can cause behaviour changes if human were infected. |
| first_indexed | 2025-11-15T13:59:52Z |
| format | Article |
| id | upm-108329 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:59:52Z |
| publishDate | 2023 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1083292025-02-20T02:36:13Z http://psasir.upm.edu.my/id/eprint/108329/ Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase Wana, Mohammed Nasiru Watanabe, Malaika Chiroma, Samaila Musa Unyah, Ngah Zasmy Basir, Rusliza Mohd Moklas, Mohamad Aris Abd Majid, Roslaini Abdullahi, Sharif Alhassan Nordin, Shariza Toxoplasma gondii (T. gondii) is a parasite capable of residing in the brain of their host which influences behaviour changes due to alterations in the neurotransmitters. Consequently, dopamine receptors (DRD) and indoleamine 2, 3 dioxygenase (IDO) dysregulation facilitate the progression of behaviour changes in a host as a response to infection. This study tested the effect of neurotransmitter changes as a result of T. gondii infection on rats cognitive impairment. The T. gondii strain of type I, II and III from Malaysia were previously identified by standard procedures. Sporulated oocysts each of type I, II and III were inoculated separately into three groups of Wistar rats (n = 9) respectively. Two separate control groups received either phosphate buffered saline (PBS) or MK-801 (dizocilpine). Behaviour changes were evaluated at nine weeks post infection in a square box, elevated plus maze and gene expression level of DRD and IDO compounds. The study revealed increased fatal feline attraction, reduced anxiety, decreased DRD and increased IDO gene expression in the T. gondii infected groups and MK-801 compared to the PBS control group. In conclusion, T. gondii infection alter the level of neurotransmitters in rat which cause cognitive impairment. This implies that all the T. gondii strain can cause behaviour changes if human were infected. Elsevier 2023 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/108329/3/108329.pdf Wana, Mohammed Nasiru and Watanabe, Malaika and Chiroma, Samaila Musa and Unyah, Ngah Zasmy and Basir, Rusliza and Mohd Moklas, Mohamad Aris and Abd Majid, Roslaini and Abdullahi, Sharif Alhassan and Nordin, Shariza (2023) Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase. Heliyon, 9 (3). art. no. e14370. pp. 1-12. ISSN 2405-8440 https://linkinghub.elsevier.com/retrieve/pii/S2405844023015773 10.1016/j.heliyon.2023.e14370 |
| spellingShingle | Wana, Mohammed Nasiru Watanabe, Malaika Chiroma, Samaila Musa Unyah, Ngah Zasmy Basir, Rusliza Mohd Moklas, Mohamad Aris Abd Majid, Roslaini Abdullahi, Sharif Alhassan Nordin, Shariza Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title | Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title_full | Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title_fullStr | Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title_full_unstemmed | Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title_short | Toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| title_sort | toxoplasma gondii induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase |
| url | http://psasir.upm.edu.my/id/eprint/108329/ http://psasir.upm.edu.my/id/eprint/108329/ http://psasir.upm.edu.my/id/eprint/108329/ http://psasir.upm.edu.my/id/eprint/108329/3/108329.pdf |