Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in small ruminants and is of considerable economic importance in many countries worldwide. The control of the disease in animals depends on the control of the disease in infected animals. Nevertheless, few countries w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Nexus Academic Publishers
2023
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/108268/ |
| _version_ | 1848865117797613568 |
|---|---|
| author | Naji Odhah, Mohammed Abdullah Jesse, Faez Firdaus Paul, Bura Thlama Garba, Bashiru Mahmood, Zaid Lim, Eric Teik Chung Mohd Lila, Mohd Azmi |
| author_facet | Naji Odhah, Mohammed Abdullah Jesse, Faez Firdaus Paul, Bura Thlama Garba, Bashiru Mahmood, Zaid Lim, Eric Teik Chung Mohd Lila, Mohd Azmi |
| author_sort | Naji Odhah, Mohammed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in small ruminants and is of considerable economic importance in many countries worldwide. The control of the disease in animals depends on the control of the disease in infected animals. Nevertheless, few countries where the disease was previously endemic have successfully eradicated the pathogen. This investigation was undertaken to determine the antibody titre (IgM and IgG) in does challenged with C. pseudotuberculosis and its Mycolic acids (MAs) immunogen extract. About 12 healthy crossbred female Boer goats were assigned into three groups (A, B and C), each comprising of 4 goats. Group A (Negative control group) was inoculated intradermally with 2 ml of sterile phosphate-buffered saline (PBS-pH 7); Group B (Mycolic acid group) was inoculated intradermally with 2 ml of immunogenic Mycolic acid extract (1g /ml); while group C (Positive control group) was inoculated intradermally with 2 ml of 109 colony-forming unit of live C. pseudotuberculosis. All the animals were observed for 90 days post-inoculation. Blood samples were collected via the jugular vein from all the groups before the inoculation and once weekly after the challenge until the end of the research period. The result of the study showed that the Immunoglobulin M (IgM) concentration in goats inoculated with C. pseudotuberculosis significantly (p |
| first_indexed | 2025-11-15T13:59:37Z |
| format | Article |
| id | upm-108268 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:59:37Z |
| publishDate | 2023 |
| publisher | Nexus Academic Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1082682024-09-10T07:52:13Z http://psasir.upm.edu.my/id/eprint/108268/ Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract Naji Odhah, Mohammed Abdullah Jesse, Faez Firdaus Paul, Bura Thlama Garba, Bashiru Mahmood, Zaid Lim, Eric Teik Chung Mohd Lila, Mohd Azmi Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in small ruminants and is of considerable economic importance in many countries worldwide. The control of the disease in animals depends on the control of the disease in infected animals. Nevertheless, few countries where the disease was previously endemic have successfully eradicated the pathogen. This investigation was undertaken to determine the antibody titre (IgM and IgG) in does challenged with C. pseudotuberculosis and its Mycolic acids (MAs) immunogen extract. About 12 healthy crossbred female Boer goats were assigned into three groups (A, B and C), each comprising of 4 goats. Group A (Negative control group) was inoculated intradermally with 2 ml of sterile phosphate-buffered saline (PBS-pH 7); Group B (Mycolic acid group) was inoculated intradermally with 2 ml of immunogenic Mycolic acid extract (1g /ml); while group C (Positive control group) was inoculated intradermally with 2 ml of 109 colony-forming unit of live C. pseudotuberculosis. All the animals were observed for 90 days post-inoculation. Blood samples were collected via the jugular vein from all the groups before the inoculation and once weekly after the challenge until the end of the research period. The result of the study showed that the Immunoglobulin M (IgM) concentration in goats inoculated with C. pseudotuberculosis significantly (p Nexus Academic Publishers 2023 Article PeerReviewed Naji Odhah, Mohammed and Abdullah Jesse, Faez Firdaus and Paul, Bura Thlama and Garba, Bashiru and Mahmood, Zaid and Lim, Eric Teik Chung and Mohd Lila, Mohd Azmi (2023) Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract. Journal of Animal Health and Production, 11 (3). 242 -249. ISSN 2308-2801 https://researcherslinks.com/journal-details/Journal-of-Animal-Health-and-Production/34/archive/2023/September 10.17582/journal.jahp/2023/11.3.242.249 |
| spellingShingle | Naji Odhah, Mohammed Abdullah Jesse, Faez Firdaus Paul, Bura Thlama Garba, Bashiru Mahmood, Zaid Lim, Eric Teik Chung Mohd Lila, Mohd Azmi Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title | Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title_full | Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title_fullStr | Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title_full_unstemmed | Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title_short | Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract |
| title_sort | immune responses of goats to corynebacterium pseudotuberculosis and its mycolic acids (mas) extract |
| url | http://psasir.upm.edu.my/id/eprint/108268/ http://psasir.upm.edu.my/id/eprint/108268/ http://psasir.upm.edu.my/id/eprint/108268/ |