Finding lead compounds for dengue antivirals from a collection of old drugs through in silico target prediction and subsequent in vitro validation.

QR Code

Finding lead compounds for dengue antivirals from a collection of old drugs through in silico target prediction and subsequent in vitro validation.

Dengue virus (DENV) infection is one of the most widely spread flavivirus infections. Despite the fatality it could cause, no antiviral treatment is currently available to treat the disease. Hence, this study aimed to repurpose old drugs as novel DENV NS3 inhibitors. Ligand-based (L-B) and proteoche...

Full description

Bibliographic Details
Main Authors:	Abdullah, Zafirah Liyana, Chee, Hui-Yee, Yusof, Rohana, Mohd Fauzi, Fazlin
Format:	Article
Published:	American Chemical Society (ACS) 2023
Online Access:	http://psasir.upm.edu.my/id/eprint/108009/

Similar Items

Integrated in silico techniques for mechanism studies of antiviral and antidiabetic compounds / Diyana Mohd Isa
by: Diyana , Mohd Isa
Published: (2020)

Expression Of Recombinant Denv Ns2b/Ns3 Protease: In Silico Screening And In Vitro Validation Of Novel Antiviral Compounds For Dengue Virus Inhibition
by: Harun, Norshidah
Published: (2024)

Antiviral peptides against dengue virus
by: Lee, Michelle Felicia *, et al.
Published: (2022)

In silico analysis for discovery of dengue virus inhibitor from natural compounds
by: Roney, Miah, et al.
Published: (2022)

Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches
by: Ahammad, Foysal, et al.
Published: (2019)

Molecular Mechanisms of Antiviral Agents against Dengue Virus
by: Lee, Michelle Felicia, et al.
Published: (2023)

Role of microRNAs in antiviral responses to dengue infection
by: Wong, Rui Rui, et al.
Published: (2020)

Synthesis, Characterization And In Silico Studies Of Piperidone Derivatives: Dengue Protease Inhibitory Studies On Selected Compounds
by: Idris, Nor Hashima
Published: (2016)

In-silico drug target design & its approaches
by: Abduallah Alsafi, Hassen Mohammed, et al.
Published: (2011)

Development of novel antiviral peptides against dengue serotypes 1-4
by: Lee, Michelle Felicia, et al.
Published: (2023)

Structure-based design of antivirals against Envelope Glycoprotein of dengue virus
by: Anasir, M. I. *, et al.
Published: (2020)

Evaluation for antiviral potential of ficus deltoidea against dengue virus type-2
by: Yuan, Seng Wu, et al.
Published: (2024)

In silico and in vitro antiviral activity evaluation of prodigiosin from Serratia marcescens against enterovirus 71
by: Muhamad Fakrulnizam Abd Aziz,, et al.
Published: (2022)

Isolation Of Antiviral Compound From Cymbopogon Nardus Methanolic Fractions
by: Reagan Entigu, Linton @ Jerah, et al.
Published: (2013)

Inhibitory effect of Sinapic acid derivatives targeting structural and non-structural proteins of dengue virus serotype 2 An in-silico assessment
by: Roney, Miah, et al.
Published: (2023)

Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus
by: Maryam, Maqsood, et al.
Published: (2020)

An antiviral composition.
by: Abu Bakar, Fatimah, et al.
Published: (2011)

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin
by: Dellafiora, Luca, et al.
Published: (2019)

Drug repurposing of clinically-approved drugs to target epithelial-mesenchymal transition using in silico analysis
by: Ong, Chun Hao
Published: (2021)

Exploration of leads from bis-indole based triazine derivatives targeting human aldose reductase in diabetic type 2: In-silico approaches
by: Roney, Miah, et al.
Published: (2025)

Cytomegalovirus replication steps and the actions of antiviral drugs
by: Abdullah, Ashwaq Ahmed, et al.
Published: (2018)

In vitro evaluation of the antiviral activity of heparan sulfate mimetic compounds against Enterovirus 71
by: Pourianfar, Hamid Reza, et al.
Published: (2012)

Circular antiviral RNA
by: Omar, Abdul Rahman, et al.
Published: (2012)

An antiviral to cure patients
by: Tang, Ashley
Published: (2021)

Manuscripts of the Old Javanese Baratayuda in the Merapi-Merbabu collection
by: Molen, Willem Van Der
Published: (2007)

Biological monitoring of environmental lead on school children subsequent to the use of unleaded gasoline (1998) in Malaysia
by: Hashim, Zailina, et al.
Published: (2005)

Identification of usnic acid derivatives as new antiviral agents via virtual screening on dengue, influenza A and avian influenza A
by: Miah, Roney
Published: (2022)

Insight into the in silico study and biological evaluation of curcumin analogue compounds as new potential inhibitors for dengue DEN2 NS2B/NS3 serine protease
by: Frimayanti, Neni, et al.
Published: (2024)

Tingkat penggunaan ubat antiviral
by: Halid, Suzalina
Published: (2022)

Donation for students from the compound collections
by: Nor Salwana, Mohammad Idris
Published: (2020)

Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study
by: Chew, K., et al.
Published: (2010)

A review with updated perspectives on the antiviral potentials of traditional medicinal plants and their prospects in antiviral therapy
by: Saifulazmi, Nur Fadlin, et al.
Published: (2022)

Phenolic compounds of Theobroma cacao L. show potential against dengue RdRp protease enzyme inhibition by In-silico docking, DFT study, MD simulation and MMGBSA calculation
by: Moyeenul Huq, A. K. M., et al.
Published: (2024)

In silico prediction and validation of Gfap as miR-3099 target in the mouse brain
by: Zainal Abidin, Shahidee, et al.
Published: (2017)

Discovery Of New Targeting Agents Against Gapdh Receptor: In Silico And In Vitro Studies
by: Noh, Muhammad Amirul Asyraf
Published: (2023)

Application of fuzzy clustering analysis to compound datasets for drug lead identification
by: Sinarwati, Mohamad Suhaili, et al.
Published: (2012)

The Liversidge nugget collection: a new look at some old gold
by: Butt, C., et al.
Published: (2011)

The Australian Work Exposures Study: Occupational Exposure to Lead and Lead Compounds.
by: Driscoll, T., et al.
Published: (2015)

Preliminary screening of potential antiviral peptide targeting EV71 virus particles using phage display peptide library
by: Tan, Sin Shen
Published: (2010)

Clinical manifestation and laboratory findings as predictive factors for dengue mortality in Kota Bharu
by: Seng, Liu Yeo
Published: (2017)