Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient

Lodderomyces elongisporus, an ascomycetous yeast, is often misidentified as Candida parapsilosis due to its physiologic similarity. Compared to Candida parapsilosis complex, L. elongisporus is still inferior in regard to incidence and virulence. We report a case of L. elongisporus fungaemia in a pat...

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Main Authors:	Zainuddin, Nurnabilah, Zainol Abidin, Nor Zanariah, Tengku Jamaluddin, Tengku Zetty Maztura, Masri, Siti Norbaya
Format:	Article
Published:	Universiti Putra Malaysia 2023
Online Access:	http://psasir.upm.edu.my/id/eprint/107986/

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author	Zainuddin, Nurnabilah Zainol Abidin, Nor Zanariah Tengku Jamaluddin, Tengku Zetty Maztura Masri, Siti Norbaya
author_facet	Zainuddin, Nurnabilah Zainol Abidin, Nor Zanariah Tengku Jamaluddin, Tengku Zetty Maztura Masri, Siti Norbaya
author_sort	Zainuddin, Nurnabilah
building	UPM Institutional Repository
collection	Online Access
description	Lodderomyces elongisporus, an ascomycetous yeast, is often misidentified as Candida parapsilosis due to its physiologic similarity. Compared to Candida parapsilosis complex, L. elongisporus is still inferior in regard to incidence and virulence. We report a case of L. elongisporus fungaemia in a patient with diabetic ketoacidosis (DKA) precipitated by COVID-19 category 5 infection. A 52-year-old diabetic and hypertensive lady was brought in for fever, cough and lethargy for four days, with sudden onset of dyspnoea. Upon arrival, she was febrile, and in metabolic ketoacidosis. Her lung auscultation was clear. SARS-CoV-2 RNA was detected via real-time polymerase chain reaction (RT-PCR). Her blood culture grew L. elongisporus, identified via matrix-assisted laser desorption/ionization time of flight (MALDI-TOF). Although treated with intravenous (IV) amphotericin B for four days, she succumbed on the sixth day of admission. Accurate identification of this yeast, especially in differentiating it with Candida parapsilosis complex, remains a diagnostic challenge for routine diagnostic laboratories. MALDI-TOF offers a reliable alternative for accurate and prompt diagnosis. Co-infections with COVID-19 have never been recorded worldwide. We highlight the first case of L. elongisporus isolation co-existing with SARS-CoV-2 infection during this pandemic.
first_indexed	2025-11-15T13:58:25Z
format	Article
id	upm-107986
institution	Universiti Putra Malaysia
institution_category	Local University
last_indexed	2025-11-15T13:58:25Z
publishDate	2023
publisher	Universiti Putra Malaysia
recordtype	eprints
repository_type	Digital Repository
spelling	upm-1079862024-09-26T04:32:24Z http://psasir.upm.edu.my/id/eprint/107986/ Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient Zainuddin, Nurnabilah Zainol Abidin, Nor Zanariah Tengku Jamaluddin, Tengku Zetty Maztura Masri, Siti Norbaya Lodderomyces elongisporus, an ascomycetous yeast, is often misidentified as Candida parapsilosis due to its physiologic similarity. Compared to Candida parapsilosis complex, L. elongisporus is still inferior in regard to incidence and virulence. We report a case of L. elongisporus fungaemia in a patient with diabetic ketoacidosis (DKA) precipitated by COVID-19 category 5 infection. A 52-year-old diabetic and hypertensive lady was brought in for fever, cough and lethargy for four days, with sudden onset of dyspnoea. Upon arrival, she was febrile, and in metabolic ketoacidosis. Her lung auscultation was clear. SARS-CoV-2 RNA was detected via real-time polymerase chain reaction (RT-PCR). Her blood culture grew L. elongisporus, identified via matrix-assisted laser desorption/ionization time of flight (MALDI-TOF). Although treated with intravenous (IV) amphotericin B for four days, she succumbed on the sixth day of admission. Accurate identification of this yeast, especially in differentiating it with Candida parapsilosis complex, remains a diagnostic challenge for routine diagnostic laboratories. MALDI-TOF offers a reliable alternative for accurate and prompt diagnosis. Co-infections with COVID-19 have never been recorded worldwide. We highlight the first case of L. elongisporus isolation co-existing with SARS-CoV-2 infection during this pandemic. Universiti Putra Malaysia 2023 Article PeerReviewed Zainuddin, Nurnabilah and Zainol Abidin, Nor Zanariah and Tengku Jamaluddin, Tengku Zetty Maztura and Masri, Siti Norbaya (2023) Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient. Malaysian Journal of Medicine and Health Sciences, 19 (suppl.16). pp. 62-64. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_supp_16_december_2023-77004 10.47836/mjmhs.19.s16.11
spellingShingle	Zainuddin, Nurnabilah Zainol Abidin, Nor Zanariah Tengku Jamaluddin, Tengku Zetty Maztura Masri, Siti Norbaya Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title	Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title_full	Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title_fullStr	Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title_full_unstemmed	Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title_short	Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient
title_sort	fatal lodderomyces elongisporus fungaemia in covid-19 patient
url	http://psasir.upm.edu.my/id/eprint/107986/ http://psasir.upm.edu.my/id/eprint/107986/ http://psasir.upm.edu.my/id/eprint/107986/

Fatal Lodderomyces elongisporus Fungaemia in COVID-19 Patient

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