Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Mitragyna speciosa Korth also known as kratom, is an herbal drug preparation for its therapeutic properties and opioid-replacement therapy. Kratom is consumed in a brewed decoction form in Malaysia and to date, no studies have characterized its chemical and toxicity profile. Thus, this study aims to...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Academic Press Inc.
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/107801/ |
| _version_ | 1848864994659139584 |
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| author | Hassan, Zurina Singh, Darshan Suhaimi, Farah Wahida Chear, Nelson Jeng-Yeou Harun, Norsyifa See, Cheah Pike Kaur, Gurjeet Mat, Noorul Hamizah Bakar, Siti Najmi Syuhadaa Mohd Yusof, Nur Sabrina Kasinather, Vicknasingam Balasingam Chawarski, Marek C. Murugaiyah, Vikneswaran Ramanathan, Surash |
| author_facet | Hassan, Zurina Singh, Darshan Suhaimi, Farah Wahida Chear, Nelson Jeng-Yeou Harun, Norsyifa See, Cheah Pike Kaur, Gurjeet Mat, Noorul Hamizah Bakar, Siti Najmi Syuhadaa Mohd Yusof, Nur Sabrina Kasinather, Vicknasingam Balasingam Chawarski, Marek C. Murugaiyah, Vikneswaran Ramanathan, Surash |
| author_sort | Hassan, Zurina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mitragyna speciosa Korth also known as kratom, is an herbal drug preparation for its therapeutic properties and opioid-replacement therapy. Kratom is consumed in a brewed decoction form in Malaysia and to date, no studies have characterized its chemical and toxicity profile. Thus, this study aims to evaluate kratom decoction's safety and toxicity profile after 28 days of treatment. Mitragynine content was quantified in kratom decoction and used as a marker to determine the concentration. Male and female Sprague Dawley rats were orally treated with vehicle or kratom decoction (10, 50 or 150 mg/kg) and two satellite groups were treated with vehicle and kratom decoction (150 mg/kg). Blood and organs were collected for hematology, biochemical and histopathology analysis at the end of treatment. No mortality was found after 28 days of treatment and no significant changes in body weight and hematology profile, except for low platelet count. High amounts of uric acid, AST, ALT and alkaline phosphatase were found in the biochemical analysis. Histological investigation of the heart and lungs detected no alterations except for the kidney, liver and brain tissues. In conclusion, repeated administration of kratom decoction provided some evidence of toxicity in the kidney and liver with no occurrence of mortality. |
| first_indexed | 2025-11-15T13:57:39Z |
| format | Article |
| id | upm-107801 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:57:39Z |
| publishDate | 2023 |
| publisher | Academic Press Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1078012024-08-19T02:00:46Z http://psasir.upm.edu.my/id/eprint/107801/ Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats Hassan, Zurina Singh, Darshan Suhaimi, Farah Wahida Chear, Nelson Jeng-Yeou Harun, Norsyifa See, Cheah Pike Kaur, Gurjeet Mat, Noorul Hamizah Bakar, Siti Najmi Syuhadaa Mohd Yusof, Nur Sabrina Kasinather, Vicknasingam Balasingam Chawarski, Marek C. Murugaiyah, Vikneswaran Ramanathan, Surash Mitragyna speciosa Korth also known as kratom, is an herbal drug preparation for its therapeutic properties and opioid-replacement therapy. Kratom is consumed in a brewed decoction form in Malaysia and to date, no studies have characterized its chemical and toxicity profile. Thus, this study aims to evaluate kratom decoction's safety and toxicity profile after 28 days of treatment. Mitragynine content was quantified in kratom decoction and used as a marker to determine the concentration. Male and female Sprague Dawley rats were orally treated with vehicle or kratom decoction (10, 50 or 150 mg/kg) and two satellite groups were treated with vehicle and kratom decoction (150 mg/kg). Blood and organs were collected for hematology, biochemical and histopathology analysis at the end of treatment. No mortality was found after 28 days of treatment and no significant changes in body weight and hematology profile, except for low platelet count. High amounts of uric acid, AST, ALT and alkaline phosphatase were found in the biochemical analysis. Histological investigation of the heart and lungs detected no alterations except for the kidney, liver and brain tissues. In conclusion, repeated administration of kratom decoction provided some evidence of toxicity in the kidney and liver with no occurrence of mortality. Academic Press Inc. 2023 Article PeerReviewed Hassan, Zurina and Singh, Darshan and Suhaimi, Farah Wahida and Chear, Nelson Jeng-Yeou and Harun, Norsyifa and See, Cheah Pike and Kaur, Gurjeet and Mat, Noorul Hamizah and Bakar, Siti Najmi Syuhadaa and Mohd Yusof, Nur Sabrina and Kasinather, Vicknasingam Balasingam and Chawarski, Marek C. and Murugaiyah, Vikneswaran and Ramanathan, Surash (2023) Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology and Pharmacology, 143. art. no. 105466. pp. 1-9. ISSN 0273-2300; EISSN: 1096-0295 https://linkinghub.elsevier.com/retrieve/pii/S0273230023001344 10.1016/j.yrtph.2023.105466 |
| spellingShingle | Hassan, Zurina Singh, Darshan Suhaimi, Farah Wahida Chear, Nelson Jeng-Yeou Harun, Norsyifa See, Cheah Pike Kaur, Gurjeet Mat, Noorul Hamizah Bakar, Siti Najmi Syuhadaa Mohd Yusof, Nur Sabrina Kasinather, Vicknasingam Balasingam Chawarski, Marek C. Murugaiyah, Vikneswaran Ramanathan, Surash Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title | Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title_full | Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title_fullStr | Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title_full_unstemmed | Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title_short | Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats |
| title_sort | evaluation of toxicity profile of kratom (mitragyna speciosa korth) decoction in rats |
| url | http://psasir.upm.edu.my/id/eprint/107801/ http://psasir.upm.edu.my/id/eprint/107801/ http://psasir.upm.edu.my/id/eprint/107801/ |