Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia
Mannheimiosis is one of the common causes of pneumonia caused by Mannheimia haemolytica. Evaluation of the hematological and serum biochemistry changes is critical to determine the effectiveness of the treatment approach in reducing the severity of infection. Healthy goats (n=20) were equally divide...
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| Format: | Article |
| Language: | English |
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Nexus Academic Publishers
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/107600/ http://psasir.upm.edu.my/id/eprint/107600/1/1679432344JAHP_11_1_73-81.pdf |
| _version_ | 1848864940551569408 |
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| author | Abdul Hamid, Fathin Faahimaah Hanif Reduan, Mohd Farhan Sabri, Jasni Abdullah, Faez Firdaus Jesse Naji Odhah, Mohammed Abdul Manaf, Nur Athirah Norsidin, Mohd Jefri Che Yahya, Siti Nor Kamaruzaman, Intan Noor Aina Mohd Rajdi, Nur Zul Izzati |
| author_facet | Abdul Hamid, Fathin Faahimaah Hanif Reduan, Mohd Farhan Sabri, Jasni Abdullah, Faez Firdaus Jesse Naji Odhah, Mohammed Abdul Manaf, Nur Athirah Norsidin, Mohd Jefri Che Yahya, Siti Nor Kamaruzaman, Intan Noor Aina Mohd Rajdi, Nur Zul Izzati |
| author_sort | Abdul Hamid, Fathin Faahimaah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mannheimiosis is one of the common causes of pneumonia caused by Mannheimia haemolytica. Evaluation of the hematological and serum biochemistry changes is critical to determine the effectiveness of the treatment approach in reducing the severity of infection. Healthy goats (n=20) were equally divided into 5 groups: Mannheimia haemolytica 107 concentration was inoculated intranasally to all goats except goats of Group 1 which served as the negative control, Group 2 was the positive control, Group 3 goats treated with oxytetracycline, Group 4 goats were treated with flunixin meglumine, and group 5 received both oxytetracycline and flunixin meglumine treatments. Blood samples were collected at 24 hours, days 5, 7, 9, 11, 14, 21, and 28 post-inoculation for the clinical pathology evaluation through complete blood count and serum biochemistry evaluation. Results showed that post-infection resulted mild fluctuation of the red blood cell parameters in the goats with a decrease in the total white blood cell count (p<0.05). The serum biochemistry shows the total protein, albumin and globulin are within the range with mild increment in creatine kinase, blood urea nitrogen, and gamma glutaryl transferase however there were increased lactate dehydrogenase levels post-infection with Mannheimia haemolytica (p<0.05). In conclusion, oxytetracycline and flunixin meglumine treatments does not have a great influence on the parameters evaluated in goats experimentally induced with Mannheimia haemolytica pneumonia. |
| first_indexed | 2025-11-15T13:56:48Z |
| format | Article |
| id | upm-107600 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:56:48Z |
| publishDate | 2023 |
| publisher | Nexus Academic Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1076002024-09-02T03:38:41Z http://psasir.upm.edu.my/id/eprint/107600/ Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia Abdul Hamid, Fathin Faahimaah Hanif Reduan, Mohd Farhan Sabri, Jasni Abdullah, Faez Firdaus Jesse Naji Odhah, Mohammed Abdul Manaf, Nur Athirah Norsidin, Mohd Jefri Che Yahya, Siti Nor Kamaruzaman, Intan Noor Aina Mohd Rajdi, Nur Zul Izzati Mannheimiosis is one of the common causes of pneumonia caused by Mannheimia haemolytica. Evaluation of the hematological and serum biochemistry changes is critical to determine the effectiveness of the treatment approach in reducing the severity of infection. Healthy goats (n=20) were equally divided into 5 groups: Mannheimia haemolytica 107 concentration was inoculated intranasally to all goats except goats of Group 1 which served as the negative control, Group 2 was the positive control, Group 3 goats treated with oxytetracycline, Group 4 goats were treated with flunixin meglumine, and group 5 received both oxytetracycline and flunixin meglumine treatments. Blood samples were collected at 24 hours, days 5, 7, 9, 11, 14, 21, and 28 post-inoculation for the clinical pathology evaluation through complete blood count and serum biochemistry evaluation. Results showed that post-infection resulted mild fluctuation of the red blood cell parameters in the goats with a decrease in the total white blood cell count (p<0.05). The serum biochemistry shows the total protein, albumin and globulin are within the range with mild increment in creatine kinase, blood urea nitrogen, and gamma glutaryl transferase however there were increased lactate dehydrogenase levels post-infection with Mannheimia haemolytica (p<0.05). In conclusion, oxytetracycline and flunixin meglumine treatments does not have a great influence on the parameters evaluated in goats experimentally induced with Mannheimia haemolytica pneumonia. Nexus Academic Publishers 2023-02-15 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/107600/1/1679432344JAHP_11_1_73-81.pdf Abdul Hamid, Fathin Faahimaah and Hanif Reduan, Mohd Farhan and Sabri, Jasni and Abdullah, Faez Firdaus Jesse and Naji Odhah, Mohammed and Abdul Manaf, Nur Athirah and Norsidin, Mohd Jefri and Che Yahya, Siti Nor and Kamaruzaman, Intan Noor Aina and Mohd Rajdi, Nur Zul Izzati (2023) Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia. Journal of Animal Health and Production, 11 (1). 73 - 81. ISSN 2308-2801 https://researcherslinks.com/current-issues/Effects-of-Oxytetracycline-and-Flunixin-Meglumine-Treatments-on-the-Haematological-and-Serum-Biochemistry-Profiles-of-Goats-Experimentally-Induced-with-Mannheimia-haemolytica-Pneumonia/34/1/6100/html 10.17582/journal.jahp/2023/11.1.73.81 |
| spellingShingle | Abdul Hamid, Fathin Faahimaah Hanif Reduan, Mohd Farhan Sabri, Jasni Abdullah, Faez Firdaus Jesse Naji Odhah, Mohammed Abdul Manaf, Nur Athirah Norsidin, Mohd Jefri Che Yahya, Siti Nor Kamaruzaman, Intan Noor Aina Mohd Rajdi, Nur Zul Izzati Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title | Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title_full | Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title_fullStr | Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title_full_unstemmed | Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title_short | Effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with Mannheimia haemolytica Pneumonia |
| title_sort | effects of oxytetracycline and flunixin meglumine treatments on the haematological and serum biochemistry profiles of goats experimentally induced with mannheimia haemolytica pneumonia |
| url | http://psasir.upm.edu.my/id/eprint/107600/ http://psasir.upm.edu.my/id/eprint/107600/ http://psasir.upm.edu.my/id/eprint/107600/ http://psasir.upm.edu.my/id/eprint/107600/1/1679432344JAHP_11_1_73-81.pdf |