Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine
The rapid and specific detection of dopamine (DA) is of great importance for diagnosis of neurodegenerative diseases. Surface plasmon resonance (SPR) sensors are promising tools for real time monitoring of biomolecular interactions. However, the sensitivity of such sensors necessitates improvement....
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/107318/ |
| _version_ | 1848864872341700608 |
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| author | Kamal Eddin, Faten Bashar Yap, Wing Fen Liew, Josephine Ying Chyi Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Abdullah, Huda |
| author_facet | Kamal Eddin, Faten Bashar Yap, Wing Fen Liew, Josephine Ying Chyi Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Abdullah, Huda |
| author_sort | Kamal Eddin, Faten Bashar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The rapid and specific detection of dopamine (DA) is of great importance for diagnosis of neurodegenerative diseases. Surface plasmon resonance (SPR) sensors are promising tools for real time monitoring of biomolecular interactions. However, the sensitivity of such sensors necessitates improvement. For this purpose, graphene oxide (GO) was employed in this work to prepare the sensor chip. Interestingly, the proposed sensor possessed an excellent performance with high sensitivity of 0.2148—¦ /pM and affinity constant of 2.148 TMˆ’ 1 . The precision for nine replicate detections of 100 fM was 0.125 (RSD). Significantly, this plasmonic based sensor has potential to determine DA in real time within 5 min. Moreover, it showed excellent reproducibility, repeatability, and selectivity to common interfering species, as well as outstanding storage stability. Considering its simple fabrication, high sensitivity and other sensing characteristics, it was found that this optical sensor showed considerable promise as a reliable technique for rapid detection and in-field measurement. |
| first_indexed | 2025-11-15T13:55:43Z |
| format | Article |
| id | upm-107318 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:55:43Z |
| publishDate | 2023 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1073182024-10-15T06:53:37Z http://psasir.upm.edu.my/id/eprint/107318/ Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine Kamal Eddin, Faten Bashar Yap, Wing Fen Liew, Josephine Ying Chyi Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Abdullah, Huda The rapid and specific detection of dopamine (DA) is of great importance for diagnosis of neurodegenerative diseases. Surface plasmon resonance (SPR) sensors are promising tools for real time monitoring of biomolecular interactions. However, the sensitivity of such sensors necessitates improvement. For this purpose, graphene oxide (GO) was employed in this work to prepare the sensor chip. Interestingly, the proposed sensor possessed an excellent performance with high sensitivity of 0.2148—¦ /pM and affinity constant of 2.148 TMˆ’ 1 . The precision for nine replicate detections of 100 fM was 0.125 (RSD). Significantly, this plasmonic based sensor has potential to determine DA in real time within 5 min. Moreover, it showed excellent reproducibility, repeatability, and selectivity to common interfering species, as well as outstanding storage stability. Considering its simple fabrication, high sensitivity and other sensing characteristics, it was found that this optical sensor showed considerable promise as a reliable technique for rapid detection and in-field measurement. Elsevier 2023 Article PeerReviewed Kamal Eddin, Faten Bashar and Yap, Wing Fen and Liew, Josephine Ying Chyi and Muhamad Fauzi, Nurul Illya and Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim and Abdullah, Huda (2023) Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine. Optics & Laser Technology, 161. art. no. 109221. pp. 1-13. ISSN 0030-3992; ESSN: 1879-2545 https://www.sciencedirect.com/science/article/pii/S0030399223001147 10.1016/j.optlastec.2023.109221 |
| spellingShingle | Kamal Eddin, Faten Bashar Yap, Wing Fen Liew, Josephine Ying Chyi Muhamad Fauzi, Nurul Illya Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim Abdullah, Huda Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title | Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title_full | Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title_fullStr | Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title_full_unstemmed | Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title_short | Development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| title_sort | development of plasmonic-based sensor for highly sensitive and selective detection of dopamine |
| url | http://psasir.upm.edu.my/id/eprint/107318/ http://psasir.upm.edu.my/id/eprint/107318/ http://psasir.upm.edu.my/id/eprint/107318/ |