A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis
In systemic lupus erythematosus (SLE), haematological abnormalities are frequent, although they are an uncommon cause of acquired von Willebrand syndrome (AVWS). AVWS is a rare condition that can cause a bleeding disorder. We presented a case of AVWS in the early diagnosis of SLE. One month before a...
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| Format: | Article |
| Language: | English |
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Fakulti Perubatan Dan Sains Kesihatan, UPM
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106813/ http://psasir.upm.edu.my/id/eprint/106813/1/106813.pdf |
| _version_ | 1848864829201186816 |
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| author | Sabtu, Noor Hayati Idris, Faridah Tohit, Eusni Rahayu Abu Bakar, Azlinda Wan Yusof, Wan Aswani Osman, Raudhawati |
| author_facet | Sabtu, Noor Hayati Idris, Faridah Tohit, Eusni Rahayu Abu Bakar, Azlinda Wan Yusof, Wan Aswani Osman, Raudhawati |
| author_sort | Sabtu, Noor Hayati |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In systemic lupus erythematosus (SLE), haematological abnormalities are frequent, although they are an uncommon cause of acquired von Willebrand syndrome (AVWS). AVWS is a rare condition that can cause a bleeding disorder. We presented a case of AVWS in the early diagnosis of SLE. One month before admission, the patient had a history of recurrent epistaxis. He presented to the hospital with symptomatic anaemia and was noted to have severe anaemia with iron deficiency. During hospitalisation, recurrent epistaxis recurred and was found to have prolonged activated partial thromboplastin time (aPTT), presence of lupus anticoagulant (LA), and lower von Willebrand factor (VWF), and factor 8 (VIII) levels. Simultaneously, he was diagnosed with SLE based on Systemic Lupus International Collaborating Clinics (SLICC) criteria. He underwent blood transfusions and was treated with immunosuppressive drugs such as steroids, mycophenolate mofetil, and an anti-fibrinolytic agent; he subsequently stopped bleeding and showed clinical improvement. |
| first_indexed | 2025-11-15T13:55:02Z |
| format | Article |
| id | upm-106813 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:55:02Z |
| publishDate | 2023 |
| publisher | Fakulti Perubatan Dan Sains Kesihatan, UPM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1068132024-11-14T04:14:08Z http://psasir.upm.edu.my/id/eprint/106813/ A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis Sabtu, Noor Hayati Idris, Faridah Tohit, Eusni Rahayu Abu Bakar, Azlinda Wan Yusof, Wan Aswani Osman, Raudhawati In systemic lupus erythematosus (SLE), haematological abnormalities are frequent, although they are an uncommon cause of acquired von Willebrand syndrome (AVWS). AVWS is a rare condition that can cause a bleeding disorder. We presented a case of AVWS in the early diagnosis of SLE. One month before admission, the patient had a history of recurrent epistaxis. He presented to the hospital with symptomatic anaemia and was noted to have severe anaemia with iron deficiency. During hospitalisation, recurrent epistaxis recurred and was found to have prolonged activated partial thromboplastin time (aPTT), presence of lupus anticoagulant (LA), and lower von Willebrand factor (VWF), and factor 8 (VIII) levels. Simultaneously, he was diagnosed with SLE based on Systemic Lupus International Collaborating Clinics (SLICC) criteria. He underwent blood transfusions and was treated with immunosuppressive drugs such as steroids, mycophenolate mofetil, and an anti-fibrinolytic agent; he subsequently stopped bleeding and showed clinical improvement. Fakulti Perubatan Dan Sains Kesihatan, UPM 2023-05-15 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/106813/1/106813.pdf Sabtu, Noor Hayati and Idris, Faridah and Tohit, Eusni Rahayu and Abu Bakar, Azlinda and Wan Yusof, Wan Aswani and Osman, Raudhawati (2023) A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis. Malaysian Journal of Medicine and Health Sciences, 19 (3). pp. 386-389. ISSN 1675-8544; eISSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2023051611572049_MJMHS_0773.pdf 10.47836/mjmhs.19.3.50 |
| spellingShingle | Sabtu, Noor Hayati Idris, Faridah Tohit, Eusni Rahayu Abu Bakar, Azlinda Wan Yusof, Wan Aswani Osman, Raudhawati A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title | A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title_full | A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title_fullStr | A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title_full_unstemmed | A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title_short | A teenage boy with Systemic Lupus Erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| title_sort | teenage boy with systemic lupus erythematosus complicated with acquired von willebrand syndrome: a rare case and challenging in making diagnosis |
| url | http://psasir.upm.edu.my/id/eprint/106813/ http://psasir.upm.edu.my/id/eprint/106813/ http://psasir.upm.edu.my/id/eprint/106813/ http://psasir.upm.edu.my/id/eprint/106813/1/106813.pdf |