A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection
Prosthetic joint infection (PJI) is a devastating complication in arthroplasty surgery. Although the prevalence is less than 2, its functional and financial implications are significant. Part of its treatment involves the usage of prolonged and high-dose systemic antibiotics. Ironically, this predis...
| Main Authors: | , , , |
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| Format: | Article |
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Springer Nature Group
2023
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106661/ |
| _version_ | 1848864800072794112 |
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| author | Tan, Eng Kee Ahmad Hanif, Khairil Anwar Jebasingam Issace, Samuel John Che-Hamzah, Fahrudin |
| author_facet | Tan, Eng Kee Ahmad Hanif, Khairil Anwar Jebasingam Issace, Samuel John Che-Hamzah, Fahrudin |
| author_sort | Tan, Eng Kee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Prosthetic joint infection (PJI) is a devastating complication in arthroplasty surgery. Although the prevalence is less than 2, its functional and financial implications are significant. Part of its treatment involves the usage of prolonged and high-dose systemic antibiotics. Ironically, this predisposes the patient to unwanted adverse effects caused by the drugs. We report a case of cefazolin-induced neutropenia that led to Streptococcus mitis (S. mitis) bacteraemia in a patient with Staphylococcus aureus PJI. There have been no previous reports on cefazolin-induced neutropenic bacteraemia complicating the treatment of PJI. This case report aims to create awareness among the attending physicians on the possibility of cefazolin-induced neutropenia, which led to bacteraemia from an opportunistic microorganism. The reversal was as simple as cessation of the antibiotic itself. However, if not recognized, it could be fatal. |
| first_indexed | 2025-11-15T13:54:34Z |
| format | Article |
| id | upm-106661 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:54:34Z |
| publishDate | 2023 |
| publisher | Springer Nature Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1066612024-08-06T03:06:07Z http://psasir.upm.edu.my/id/eprint/106661/ A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection Tan, Eng Kee Ahmad Hanif, Khairil Anwar Jebasingam Issace, Samuel John Che-Hamzah, Fahrudin Prosthetic joint infection (PJI) is a devastating complication in arthroplasty surgery. Although the prevalence is less than 2, its functional and financial implications are significant. Part of its treatment involves the usage of prolonged and high-dose systemic antibiotics. Ironically, this predisposes the patient to unwanted adverse effects caused by the drugs. We report a case of cefazolin-induced neutropenia that led to Streptococcus mitis (S. mitis) bacteraemia in a patient with Staphylococcus aureus PJI. There have been no previous reports on cefazolin-induced neutropenic bacteraemia complicating the treatment of PJI. This case report aims to create awareness among the attending physicians on the possibility of cefazolin-induced neutropenia, which led to bacteraemia from an opportunistic microorganism. The reversal was as simple as cessation of the antibiotic itself. However, if not recognized, it could be fatal. Springer Nature Group 2023 Article NonPeerReviewed Tan, Eng Kee and Ahmad Hanif, Khairil Anwar and Jebasingam Issace, Samuel John and Che-Hamzah, Fahrudin (2023) A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection. Cureus, 15 (2). pp. 1-6. ISSN 2168-8184 https://www.cureus.com/articles/124330-a-rare-occurrence-of-opportunistic-infection-by-streptococcus-mitis-due-to-antibiotic-induced-neutropenia-in-prosthetic-joint-infection#!/ 10.7759/cureus.35583 |
| spellingShingle | Tan, Eng Kee Ahmad Hanif, Khairil Anwar Jebasingam Issace, Samuel John Che-Hamzah, Fahrudin A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title | A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title_full | A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title_fullStr | A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title_full_unstemmed | A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title_short | A rare occurrence of opportunistic infection by Streptococcus mitis due to antibiotic-induced neutropenia in Prosthetic joint infection |
| title_sort | rare occurrence of opportunistic infection by streptococcus mitis due to antibiotic-induced neutropenia in prosthetic joint infection |
| url | http://psasir.upm.edu.my/id/eprint/106661/ http://psasir.upm.edu.my/id/eprint/106661/ http://psasir.upm.edu.my/id/eprint/106661/ |