Karanjin: a potential furanoflavonoid for neuroprotection
Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pharmacolog...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Springer Science and Business Media LLC
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106329/ |
| _version_ | 1848864748099076096 |
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| author | Gnanaraj, Charles Govendan, Mogana Loo, Ching-Yee Yong, Yoong Soon Sekar, Mahendran Mat Taib, Che Norma Subramaniam, Shamala Devi Shah, Muhammad Dawood Lee, Wing-Hin |
| author_facet | Gnanaraj, Charles Govendan, Mogana Loo, Ching-Yee Yong, Yoong Soon Sekar, Mahendran Mat Taib, Che Norma Subramaniam, Shamala Devi Shah, Muhammad Dawood Lee, Wing-Hin |
| author_sort | Gnanaraj, Charles |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pharmacology and exerting potential therapeutic values in pre-clinical studies. The review aims to highlight the potential of karanjin as a neuroprotective agent with the significance of modulating the underlying molecular mechanistic pathways. Common neurodegenerative diseases reported globally include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. The main problem in the treatment of neurodegenerative diseases is the effect of the prescribed drugs for the underlying conditions is only momentary whereby a permanent solution is unavailable. Bioactive compounds under the class of flavonoids have largely been acknowledged for neuroprotection in pre-clinical studies and partial clinical trials through various mechanism of action such as modulation of NF-kB pathway, inhibition of oxidative stress, modulation of PI3K/Akt, and more. Molecular docking results of karanjin have proven the potential against Alzheimer’s and Parkinson’s disease through modulation of molecular targets adenosine A2A receptor, α-synuclein, catechol-O-methyltransferase, monoamine oxidase B, angiotensin converting enzyme, β-site APP cleaving enzyme, glycogen synthase kinase-3, TNF-α converting enzyme, and acetylcholinesterase involved in the disease progression, compared to commercial standard drugs. The review emphasizes the optimization method for the isolation of karanjin and the various impending mechanistic effects of karanjin in modulating neurodegenerative diseases. |
| first_indexed | 2025-11-15T13:53:44Z |
| format | Article |
| id | upm-106329 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:53:44Z |
| publishDate | 2024 |
| publisher | Springer Science and Business Media LLC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1063292024-06-16T03:06:32Z http://psasir.upm.edu.my/id/eprint/106329/ Karanjin: a potential furanoflavonoid for neuroprotection Gnanaraj, Charles Govendan, Mogana Loo, Ching-Yee Yong, Yoong Soon Sekar, Mahendran Mat Taib, Che Norma Subramaniam, Shamala Devi Shah, Muhammad Dawood Lee, Wing-Hin Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pharmacology and exerting potential therapeutic values in pre-clinical studies. The review aims to highlight the potential of karanjin as a neuroprotective agent with the significance of modulating the underlying molecular mechanistic pathways. Common neurodegenerative diseases reported globally include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. The main problem in the treatment of neurodegenerative diseases is the effect of the prescribed drugs for the underlying conditions is only momentary whereby a permanent solution is unavailable. Bioactive compounds under the class of flavonoids have largely been acknowledged for neuroprotection in pre-clinical studies and partial clinical trials through various mechanism of action such as modulation of NF-kB pathway, inhibition of oxidative stress, modulation of PI3K/Akt, and more. Molecular docking results of karanjin have proven the potential against Alzheimer’s and Parkinson’s disease through modulation of molecular targets adenosine A2A receptor, α-synuclein, catechol-O-methyltransferase, monoamine oxidase B, angiotensin converting enzyme, β-site APP cleaving enzyme, glycogen synthase kinase-3, TNF-α converting enzyme, and acetylcholinesterase involved in the disease progression, compared to commercial standard drugs. The review emphasizes the optimization method for the isolation of karanjin and the various impending mechanistic effects of karanjin in modulating neurodegenerative diseases. Springer Science and Business Media LLC 2024-02 Article PeerReviewed Gnanaraj, Charles and Govendan, Mogana and Loo, Ching-Yee and Yong, Yoong Soon and Sekar, Mahendran and Mat Taib, Che Norma and Subramaniam, Shamala Devi and Shah, Muhammad Dawood and Lee, Wing-Hin (2024) Karanjin: a potential furanoflavonoid for neuroprotection. Phytochemistry Reviews. pp. 1-25. ISSN 1568-7767; ESSN: 1572-980X (In Press) https://link.springer.com/article/10.1007/s11101-024-09925-z 10.1007/s11101-024-09925-z |
| spellingShingle | Gnanaraj, Charles Govendan, Mogana Loo, Ching-Yee Yong, Yoong Soon Sekar, Mahendran Mat Taib, Che Norma Subramaniam, Shamala Devi Shah, Muhammad Dawood Lee, Wing-Hin Karanjin: a potential furanoflavonoid for neuroprotection |
| title | Karanjin: a potential furanoflavonoid for neuroprotection |
| title_full | Karanjin: a potential furanoflavonoid for neuroprotection |
| title_fullStr | Karanjin: a potential furanoflavonoid for neuroprotection |
| title_full_unstemmed | Karanjin: a potential furanoflavonoid for neuroprotection |
| title_short | Karanjin: a potential furanoflavonoid for neuroprotection |
| title_sort | karanjin: a potential furanoflavonoid for neuroprotection |
| url | http://psasir.upm.edu.my/id/eprint/106329/ http://psasir.upm.edu.my/id/eprint/106329/ http://psasir.upm.edu.my/id/eprint/106329/ |