The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review
Omega-3 fatty acids (ω-3 FAs), typically found in fish oils and marine-based products, are important fatty acids due to their beneficial activities toward human health, such as anti- inflammation, immune-stimulant, lowering the risk of cardiovascular disease and reducing blood pressure. Therefore, t...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Open Science Publishers LLP Inc.
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106209/ |
| _version_ | 1848864717350633472 |
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| author | Irnawati, Irnawati Windarsih, Anjar Putri, Angita Rosiana Ahmad Fadzillah, Nurulhidayah Azmi, Aida Azrina Kusbandari, Aprilia Rohman, Abdul |
| author_facet | Irnawati, Irnawati Windarsih, Anjar Putri, Angita Rosiana Ahmad Fadzillah, Nurulhidayah Azmi, Aida Azrina Kusbandari, Aprilia Rohman, Abdul |
| author_sort | Irnawati, Irnawati |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Omega-3 fatty acids (ω-3 FAs), typically found in fish oils and marine-based products, are important fatty acids due to their beneficial activities toward human health, such as anti- inflammation, immune-stimulant, lowering the risk of cardiovascular disease and reducing blood pressure. Therefore, the determination of ω-3 FAs for quality control of products containing these FAs is very important. Molecular spectroscopic methods offered simple, fast, and reliable analytical methods for quality controls of food and pharmaceutical products containing ω-3 FAs since a large amount of information could be retrieved from molecular spectra. This review highlighted the employment of molecular spectroscopy such as near-infrared (NIR), Fourier transform infrared (FTIR), Raman, and nuclear magnetic resonance (NMR) spectrometer combined with multivariate data analysis or chemometrics for analysis of ω-3 FAs in fish oil-based products. From this review, it is reported that the combination of molecular spectroscopy and chemometrics could be used as effective analytical techniques for the analysis of ω-3 FAs, especially eicosapentaenoic acid (C20:5, ω-3) and docosahexaenoic acid (C22:6, ω-3), with high accuracy and high precision. The results of quantitative analysis of ω-3 FAs from NIR, FTIR, Raman, and NMR were comparable to those reference results obtained from gas chromatography-mass spectrometry measurement. In the future, collaborative studies through proficiency testing should be performed to get standardized methods based on molecular spectroscopy and chemometrics. |
| first_indexed | 2025-11-15T13:53:15Z |
| format | Article |
| id | upm-106209 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:53:15Z |
| publishDate | 2024 |
| publisher | Open Science Publishers LLP Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1062092024-05-07T22:58:54Z http://psasir.upm.edu.my/id/eprint/106209/ The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review Irnawati, Irnawati Windarsih, Anjar Putri, Angita Rosiana Ahmad Fadzillah, Nurulhidayah Azmi, Aida Azrina Kusbandari, Aprilia Rohman, Abdul Omega-3 fatty acids (ω-3 FAs), typically found in fish oils and marine-based products, are important fatty acids due to their beneficial activities toward human health, such as anti- inflammation, immune-stimulant, lowering the risk of cardiovascular disease and reducing blood pressure. Therefore, the determination of ω-3 FAs for quality control of products containing these FAs is very important. Molecular spectroscopic methods offered simple, fast, and reliable analytical methods for quality controls of food and pharmaceutical products containing ω-3 FAs since a large amount of information could be retrieved from molecular spectra. This review highlighted the employment of molecular spectroscopy such as near-infrared (NIR), Fourier transform infrared (FTIR), Raman, and nuclear magnetic resonance (NMR) spectrometer combined with multivariate data analysis or chemometrics for analysis of ω-3 FAs in fish oil-based products. From this review, it is reported that the combination of molecular spectroscopy and chemometrics could be used as effective analytical techniques for the analysis of ω-3 FAs, especially eicosapentaenoic acid (C20:5, ω-3) and docosahexaenoic acid (C22:6, ω-3), with high accuracy and high precision. The results of quantitative analysis of ω-3 FAs from NIR, FTIR, Raman, and NMR were comparable to those reference results obtained from gas chromatography-mass spectrometry measurement. In the future, collaborative studies through proficiency testing should be performed to get standardized methods based on molecular spectroscopy and chemometrics. Open Science Publishers LLP Inc. 2024 Article PeerReviewed Irnawati, Irnawati and Windarsih, Anjar and Putri, Angita Rosiana and Ahmad Fadzillah, Nurulhidayah and Azmi, Aida Azrina and Kusbandari, Aprilia and Rohman, Abdul (2024) The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review. Journal of Applied Pharmaceutical Science, 14 (1). pp. 45-53. ISSN 2231-3354 https://japsonline.com/abstract.php?article_id=4116 10.7324/JAPS.2024.139258 |
| spellingShingle | Irnawati, Irnawati Windarsih, Anjar Putri, Angita Rosiana Ahmad Fadzillah, Nurulhidayah Azmi, Aida Azrina Kusbandari, Aprilia Rohman, Abdul The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title | The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title_full | The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title_fullStr | The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title_full_unstemmed | The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title_short | The use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| title_sort | use of spectroscopic methods in combination with multivariate data analysis for determination of omega fatty acids: a review |
| url | http://psasir.upm.edu.my/id/eprint/106209/ http://psasir.upm.edu.my/id/eprint/106209/ http://psasir.upm.edu.my/id/eprint/106209/ |