Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis
Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/106166/ http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf |
| _version_ | 1848864706452783104 |
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| author | Tu, An Zhu, Xiaoning Dastjerdi, Paniz Zarghami Yin, Yue Peng, Mengyun Zheng, Ding Peng, Zhaoxuan Wang, Encheng Wang, Xiaodong Jing, Wang |
| author_facet | Tu, An Zhu, Xiaoning Dastjerdi, Paniz Zarghami Yin, Yue Peng, Mengyun Zheng, Ding Peng, Zhaoxuan Wang, Encheng Wang, Xiaodong Jing, Wang |
| author_sort | Tu, An |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study aims to address this gap. Methods: Publications were collected from PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Sino Med, VIP, and Wan Fang Databases. Relative risk (RR) was calculated with a 95 confidence interval (CI). Heterogeneity was assessed. The Cochrane Collaboration's tool was used to assess the risk of bias. Results: 10 studies with 2702 patients showed that the combination therapy significantly reduced the incidence of HCC in patients with post-hepatitis B cirrhosis at 1, 3, and 5 years. However, the preventive effects of TCM were in compensated cirrhosis, but not the decompensated cirrhosis. Furthermore, TCM correlated with improved liver function and enhanced virological response. Conclusion: Combination therapy with TCM demonstrated the certain potential in reducing the incidence of HCC in patients with hepatitis B cirrhosis. This is attrinuted to the improvement of liver function and enhancement of the viral response. However, the efficacy of TCM in the field still needs more high-quality RCTs to provide stronger evidence in the future. |
| first_indexed | 2025-11-15T13:53:04Z |
| format | Article |
| id | upm-106166 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:53:04Z |
| publishDate | 2024 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1061662024-09-03T08:22:12Z http://psasir.upm.edu.my/id/eprint/106166/ Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis Tu, An Zhu, Xiaoning Dastjerdi, Paniz Zarghami Yin, Yue Peng, Mengyun Zheng, Ding Peng, Zhaoxuan Wang, Encheng Wang, Xiaodong Jing, Wang Background: Traditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing the incidence of HCC in patients with chronic hepatitis B-related cirrhosis remains unclear. This study aims to address this gap. Methods: Publications were collected from PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Sino Med, VIP, and Wan Fang Databases. Relative risk (RR) was calculated with a 95 confidence interval (CI). Heterogeneity was assessed. The Cochrane Collaboration's tool was used to assess the risk of bias. Results: 10 studies with 2702 patients showed that the combination therapy significantly reduced the incidence of HCC in patients with post-hepatitis B cirrhosis at 1, 3, and 5 years. However, the preventive effects of TCM were in compensated cirrhosis, but not the decompensated cirrhosis. Furthermore, TCM correlated with improved liver function and enhanced virological response. Conclusion: Combination therapy with TCM demonstrated the certain potential in reducing the incidence of HCC in patients with hepatitis B cirrhosis. This is attrinuted to the improvement of liver function and enhancement of the viral response. However, the efficacy of TCM in the field still needs more high-quality RCTs to provide stronger evidence in the future. Elsevier Ltd 2024-02 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf Tu, An and Zhu, Xiaoning and Dastjerdi, Paniz Zarghami and Yin, Yue and Peng, Mengyun and Zheng, Ding and Peng, Zhaoxuan and Wang, Encheng and Wang, Xiaodong and Jing, Wang (2024) Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis. Heliyon, 10 (3). art. no. e24437. pp. 1-12. ISSN 2405-8440 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183867994&url=10.1016%2fj.heliyon.2024.e24437&partnerID=40&md5=cd9c8b6c2ac96691375e179b71d0979a 10.1016/j.heliyon.2024.e24437 |
| spellingShingle | Tu, An Zhu, Xiaoning Dastjerdi, Paniz Zarghami Yin, Yue Peng, Mengyun Zheng, Ding Peng, Zhaoxuan Wang, Encheng Wang, Xiaodong Jing, Wang Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title | Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title_full | Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title_fullStr | Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title_full_unstemmed | Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title_short | Evaluate the clinical efficacy of traditional Chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis: a systematic review and meta-analysis |
| title_sort | evaluate the clinical efficacy of traditional chinese medicine as the neoadjuvant treatment in reducing the incidence of hepatocellular carcinoma in patients with hepatitis b-related cirrhosis: a systematic review and meta-analysis |
| url | http://psasir.upm.edu.my/id/eprint/106166/ http://psasir.upm.edu.my/id/eprint/106166/ http://psasir.upm.edu.my/id/eprint/106166/ http://psasir.upm.edu.my/id/eprint/106166/1/1-s2.0-S2405844024004687-main.pdf |