Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Research
2024
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/105629/ |
| _version_ | 1848864564804845568 |
|---|---|
| author | Hardiany, Novi Silvia Dewi, Putri Krishna Kumara Dewi, Syarifah Tejo, Bimo A. |
| author_facet | Hardiany, Novi Silvia Dewi, Putri Krishna Kumara Dewi, Syarifah Tejo, Bimo A. |
| author_sort | Hardiany, Novi Silvia |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent. |
| first_indexed | 2025-11-15T13:50:49Z |
| format | Article |
| id | upm-105629 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:50:49Z |
| publishDate | 2024 |
| publisher | Nature Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1056292024-05-09T03:28:50Z http://psasir.upm.edu.my/id/eprint/105629/ Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats Hardiany, Novi Silvia Dewi, Putri Krishna Kumara Dewi, Syarifah Tejo, Bimo A. In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent. Nature Research 2024-01 Article PeerReviewed Hardiany, Novi Silvia and Dewi, Putri Krishna Kumara and Dewi, Syarifah and Tejo, Bimo A. (2024) Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats. Scientific Reports, 14 (1). art. no. 603. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-51221-5?error=cookies_not_supported&code=9a8df4c6-59b9-48ae-bc99-cc30a3759e08 10.1038/s41598-024-51221-5 |
| spellingShingle | Hardiany, Novi Silvia Dewi, Putri Krishna Kumara Dewi, Syarifah Tejo, Bimo A. Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_full | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_fullStr | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_full_unstemmed | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_short | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_sort | exploration of neuroprotective effect from coriandrum sativum l. ethanolic seeds extracts on brain of obese rats |
| url | http://psasir.upm.edu.my/id/eprint/105629/ http://psasir.upm.edu.my/id/eprint/105629/ http://psasir.upm.edu.my/id/eprint/105629/ |