Drug repurposing of clinically-approved drugs to target epithelial-mesenchymal transition using in silico analysis

QR Code

Drug repurposing of clinically-approved drugs to target epithelial-mesenchymal transition using in silico analysis

Epithelial-mesenchymal transition (EMT) is a process where epithelial cells transform into mesenchymal cells type like fibroblasts and myofibroblasts. In the process, the epithelial cells lose their epithelial phenotype with reduced apicalbasal polarity, while acquiring new mesenchymal traits wit...

Full description

Bibliographic Details
Main Author:	Ong, Chun Hao
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Drug Repositioning Fibroblasts
Online Access:	http://psasir.upm.edu.my/id/eprint/103868/ http://psasir.upm.edu.my/id/eprint/103868/1/ONG%20CHUN%20HAO%20-%20IR.pdf

Similar Items

Drug repurposing of clinically approved drugs to target epithelial-mesenchymal transition using molecular docking approach
by: Chun Hao, Ong, et al.
Published: (2023)

Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches
by: Roney, Miah, et al.
Published: (2025)

Targeting inflammation in non-small cell lung cancer through drug repurposing
by: Rajasegaran, Thiviyadarshini, et al.
Published: (2023)

Approved and experimental small-molecule oncology kinase inhibitor drugs: a mid-2016 overview
by: Fischer, Peter M.
Published: (2017)

Application of a human primary epithelial-fibroblast co-culture system to study fibrosis
by: Richardson, Jaineeta
Published: (2017)

Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
by: Elaskalani, O., et al.
Published: (2017)

In-silico drug target design & its approaches
by: Abduallah Alsafi, Hassen Mohammed, et al.
Published: (2011)

Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012)

Targeted bio-distribution of drugs to the lymphatic system
by: Jewell, Adelaide
Published: (2022)

Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
by: Razak, Eliza, et al.
Published: (2016)

Development of multifunctional drug delivery systems based on virus-like nanoparticles for cancer targeting drug delivery
by: Biabanikhankahdani, Roya
Published: (2017)

Systematic overview of clinical trials of antiarrhythmic drugs
by: Shilbayeh, Sirin
Published: (1998)

Antibacterial and antioxidant activities of Piper cubeba L. berries extract and its cytotoxicity effect on 3T3 human fibroblast and HEPG2 cell lines
by: Lou, Shuai Qiang
Published: (2021)

Development of an EGFR-targeted Drug Delivery System for Glioblastoma
by: Zhao, Zi-Ruo
Published: (2023)

Silk Road: Ebay for drugs
by: Barratt, Monica
Published: (2012)

Improving Nanoparticle Drug loading: Matching Polymer to Drug Properties and making of Polymer coated Drug Nanoparticles
by: ANIMASAWUN, R.K
Published: (2020)

Analysis of adverse drug reactions related to drug-induced renal injury based on spontaneous adverse drug reactions reporting in Malaysia 2010 – 2014 / Nurulmaya Ahmad Sa'ad
by: Ahmad Sa'ad, Nurulmaya
Published: (2016)

Factor of drug rejections and stigma toward drug consumers and drugs / Seema Shamira Muhammad Sani Surinder, Abdul Rauf Ridzuan and Rosilawati Sultan Mohideen
by: Muhammad Sani Surinder, Seema Shamira, et al.
Published: (2019)

An investigation into the drug disposition of the spleen organ as a potential immuno-therapeutic target
by: Inuwa, Patience G.
Published: (2024)

Gastric-targeted drug delivery by learning from Helicobacter pylori
by: Paraskevopoulou, Vasiliki
Published: (2019)

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells
by: Schwab, R., et al.
Published: (2017)

Mefenamic acid inhibit transforming growth factor-beta type-1: Repurposing anti-inflammatory drugs in wound healing using in-silico approaches
by: Roney, Miah, et al.
Published: (2023)

Assessment of pharmacists, public and general retailers perspectives, awareness and knowledge of registered drugs and unregistered drugs in Klang Valley / Nur Wahida Zulkifli
by: Zulkifli, Nur Wahida
Published: (2018)

More On Stimulant Drugs In Sports
by: Abd Razak, Dzulkifli
Published: (1996)

The suppression of illicit drugs through international law
by: Boister, Neil
Published: (1998)

Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets
by: Alsayed, S.S.R., et al.
Published: (2023)

Clinical Pharmacology Of Antimalarial Drugs.
Published: (1989)

Developing stromal instructive niches to promote wound healing
by: Latif, Arsalan
Published: (2021)

Learning lessons from adverse drug reactions in children
by: Sammons, Helen, et al.
Published: (2016)

Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition
by: Hodge, S., et al.
Published: (2009)

Epithelial to mesenchymal transition and eepithelialisation in wound healing: a review of comparison
by: Abid Nordin,, et al.
Published: (2018)

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing
by: Todd, Ian, et al.
Published: (2017)

Pharmacology classification of drugs
by: Saxena, Anil Kumar
Published: (2012)

A grounded study of the experience of detoxification from psychoactive drugs.
by: Bartu, Anne
Published: (1998)

Drug dealers using teens as front- liners
Published: (2008)

Mathematical and computational models of drug transport in tumours
by: Groh, C.M., et al.
Published: (2014)

Does Drug Education Work?
by: Midford, Richard
Published: (2000)

An observational feasibility study of a new anaesthesia drug storage tray
by: Almghairbi, Dalal S., et al.
Published: (2018)

Nucleoside based self-assembling drugs for localized drug delivery
by: Skilling, Kathryn J., et al.
Published: (2018)

Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects.
by: Hackett, T.-L., et al.
Published: (2009)