Pharmacological and toxicological effects of 6-hydroxy-2-mercaptopurine and 6-thioguanine in in vitro and in vivo models of arthritis

QR Code

Pharmacological and toxicological effects of 6-hydroxy-2-mercaptopurine and 6-thioguanine in in vitro and in vivo models of arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto-immune disease characterized by symmetrical joint inflammation, destruction of articular cartilage and periarticular tissues leading to loss of joint function and morbidity. The abnormal propagation and activation in many types of...

Full description

Bibliographic Details
Main Author:	Nordin, Nurul Syuhada
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Arthritis - diagnosis Thioguanine - adverse effects Mercaptopurine - adverse effects
Online Access:	http://psasir.upm.edu.my/id/eprint/103812/ http://psasir.upm.edu.my/id/eprint/103812/1/THESIS%20B5%20NURUL%20SYUHADA%20-%20IR.pdf

Similar Items

Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo
by: Che Ku Daud, Che Ku Dahlan
Published: (2020)

Amitraz Exposure and Risks to Pesticide Applicators and Nearby Residents in Zangiabad, Iran
by: Aghasi, Majid
Published: (2010)

Effects of Erythroxylum Cuneatum (Miq.) Kurz on cellular and synaptic adaptation of chronic morphine-addicted human neuroblastoma cell line at protein level
by: Sulaiman, Noor Azuin
Published: (2017)

Toxicology evaluations of Rhaphidophora decursiva (Roxb.) Schott extract in Sprague Dawley
by: Arsad, Siti Suriani
Published: (2013)

Creatine kinase and SLCO1B1 RS4363657 polymorphism in Malaysian dyslipidaemic patients prescribed with statin drugs
by: Meor Anuar Shuhaili, Meor Fairuz Rizal
Published: (2016)

Characterization of antibiotic susceptibility and high level aminoglycoside resistant genes in Enterococcus faecalis and Enterococcus faecium clinical isolates
by: Moussa, Ayan Aden
Published: (2018)

Antiplasmodium and chloroquin resistance reversing effects of selected pure phytochemicals
by: Ibraheem, Zaid Osamah
Published: (2017)

A mixed-methods approach to develop and validate the Malaysia anti-hypertensive agents non-adherence scale among hypertensive patients in Kuala Lumpur, Malaysia
by: Yew, Sheng Qian
Published: (2022)

Antidiabetic and immunological effects of ginger rhizome on streptozotocin-nicotinamide induced diabetic rats
by: Qomi, Mansooreh Sadat Mojani
Published: (2013)

Synthesis, characterization, and biological properties of nickel (II) complexes with derivatives of testosterone thiosemicarbazone
by: Heng, Mok Piew
Published: (2015)

Dermal exposure to pesticides and health symptoms of paddy farmers in Seberang Perak, Malaysia
by: Mohammad, Khadijah
Published: (2019)

Quantification of bioactive compounds in instant coffee and their effects on gastric release using HGT-1 cells
by: Wan Kamarul Zaman, Wan Syamimi
Published: (2020)

Prediction of human discomfort perception from combination of noise and translational vibration exposure in a vibro-acoustic environment
by: Aladdin, Mohd Farid
Published: (2020)

Predicting seat transmissibility of seated human body on suspension seat exposed to vertical whole-body vibration
by: Adam, Siti Aisyah
Published: (2020)

Safety of paracetamol in osteoarthritis
by: Kaur, Jaspreet
Published: (2022)

Tamarindus Indica L. Pulp Aqueous Extract Effects in High Fat Diet-Induced Obese Sprague-Dawley Rats
by: Azman, Khairunnuur Fairuz
Published: (2010)

Knowledge, Attitude and Practice Regarding Hormonal Emergency Contraception Aamong Married Female Staff in Universiti Putra Malaysia
by: Sharj Abad, Fatemeh Najafi
Published: (2010)

Ambient Air Pollution and its Association with the Respiratory Health of Asthmatic Primary School Children in Selected Urban, Rural and Industrial Areas in Selangor and Kuala Lumpur
by: Zakaria, Junaidah
Published: (2010)

Putative apoptosis effect of Momordica charantia Linn. extracts in human lung cancer cell line A549
by: K Thiagarajan, Siroshini
Published: (2019)

Investigation of melanogenesis using neonatal normal human epidermal melanocyte treated with mawa young coconut water
by: Ansari, Sara
Published: (2015)

Dermal exposure assessment of glyphosate herbicide among pesticide handlers in selected agriculture sectors in Malaysia
by: Mustafa Udin, Nurulain
Published: (2021)

Antimicrobial activities and potential targets of persian shallot (Allium stipitatum regel) extracts and its isolated compound 2- (Methyldithio) pyridine-3-carbonitrile
by: Karunanidhi, Arunkumar
Published: (2016)

Characterisation of hyaluronidase, biofilm formation and emm type among invasive and non-invasive Streptococcus pyogenes clinical isolates in two hospitals in Malaysia
by: Wan Mansor, Wan Muhammad Zamir
Published: (2019)

Effects of cobalt-60 gamma irradiation on microbial contaminants and phytochemical constituents of different medicinal plants
by: Mhd Jamal, Syafiqah
Published: (2020)

Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models
by: Muhammad Amali, Abubakar
Published: (2015)

Association between hand-arm vibration syndrome and vibrotactile perception thresholds among power tool users in an automobile industry, Malaysia
by: Yusoff, Nor Maizura
Published: (2012)

Evaluation of anti-diabetic and immunomodulatory activity of polyphenols derived from Cassia auriculata L. on induced diabetic rat
by: Mathew, Cini John
Published: (2012)

Content of heavy metals (Ni, Cd, Pb) in skin lightening products and dermal health risk among young adult women
by: Rusmadi, Siti Zulaikha
Published: (2016)

Effects of dabai (Canarium odontophyllum Miq) fruit extract on biochemical parameters of obese diabetic rats
by: Mokiran, Nurul Nadirah
Published: (2014)

Effect of pomegranate on metabolic indices and inflammatory biomarkers in streptozocotocin-nicotinamide induced diabetic rats
by: Rouhi, Seyedeh Zeinab Taheri
Published: (2015)

Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
by: Ismail, Nur Izzati
Published: (2015)

Hepatoprotective activity of Dicranopteris linearis (Burm. f.) Underw. leaf methanol extract and its ethyl acetate fraction
by: Kamisan, Farah Hidayah
Published: (2017)

Influence of polycyclic aromatic hydrocarbon and genetic polymorphisms (cyp1a1, gstm1, gstt1) on pyrene metabolite and dna damage among children in the Klang Valley, Malaysia
by: Hisamuddin, Nur Hazirah
Published: (2022)

Level of pain and satisfaction with pain management after lower segment caesarean section among Malaysian women in two public hospitals
by: N.Govindasamy, Thanageswary
Published: (2019)

Bioavailable heavy metal concentration in classroom dust and related health risk assessment of primary school children in Rawang, Malaysia
by: Tan, Sock Yin
Published: (2020)

Influence of traffic-related air pollution exposure on respiratory health, TNfa and CYP1A1 gene and histone modifications among school children in the Klang Valley, Malaysia
by: Suhaimi, Nur Faseeha
Published: (2021)

The impact of childhood exposure to destructive forms of inter-parental conflict and of separation/divorce
by: Jones, Richard T.
Published: (2018)

Effects of Mitragynine on Locomotor and Anxiety in Rats Subjected to Restraint Stress
by: Adib Ridzuan, Nurul Raudzah
Published: (2010)

Composition, concentration and distribution of linear alkylbenzenes in surface sediments from selected locations in Malaysia
by: Alkhadher, Sadeq Abdullah Abdo
Published: (2017)

Relationship between serum IgG level, fractional exhaled nitric oxide and microbial contamination in metalworking fluids among machinists in Nilai, Negeri Sembilan, Malaysia
by: Hashim, Nuurl Maizura
Published: (2016)