The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway
Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, there is no effective treatment for hair loss. It is known that honeybee propolis has various biological activities, including stimulating the pro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Published: |
J-Stage
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/103664/ |
| _version_ | 1848864076346687488 |
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| author | Tang, Yulan Wang, Chen Desamero, Mark Joseph M. Mun, Keong Kok Chambers, James Kenn Uchida, Kazuyuki Kominami, Yuri Ushio, Hideki Cervancia, Cleofas Estacio, Maria Amelita Kyuwa, Shigeru Kakuta, Shigeru |
| author_facet | Tang, Yulan Wang, Chen Desamero, Mark Joseph M. Mun, Keong Kok Chambers, James Kenn Uchida, Kazuyuki Kominami, Yuri Ushio, Hideki Cervancia, Cleofas Estacio, Maria Amelita Kyuwa, Shigeru Kakuta, Shigeru |
| author_sort | Tang, Yulan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, there is no effective treatment for hair loss. It is known that honeybee propolis has various biological activities, including stimulating the proliferation of hair matrix keratinocytes. However, little is known with the hair promoting activity of stingless bee propolis. Hence, this study investigates the hair growth-promoting activity of Philippines stingless bee propolis extract and the underlying a molecular mechanism of promoting hair growth. For the evaluation of hair growth stimulating activity, 99.5% ethanolic extract of Philippines stingless bee propolis is examined using the simple shaving model in C57BL/6N mice. Melaninization of dorsal skin and histological analysis of hair follicles (HFs) revealed that propolis promotes hair growth by stimulating HFs development. The expression of mRNA (Wnt3a, Ctnnb1/β-catenin, Lef1, and Bmp2) and protein (WNT3A and β-catenin) of selected Wnt/β-catenin associated genes explains Philippines stingless bee propolis promoting HFs development by activating Wnt/β-catenin signaling pathway. These results suggest that the treatment of propolis strongly promotes hair growth by stimulating the development of HFs via activation of Wnt/β-catenin signaling pathway. This further indicates the potential of Philippines stingless bee propolis as a novel promising agricultural product for hair growth. |
| first_indexed | 2025-11-15T13:43:04Z |
| format | Article |
| id | upm-103664 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:43:04Z |
| publishDate | 2022 |
| publisher | J-Stage |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1036642023-05-02T06:36:14Z http://psasir.upm.edu.my/id/eprint/103664/ The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway Tang, Yulan Wang, Chen Desamero, Mark Joseph M. Mun, Keong Kok Chambers, James Kenn Uchida, Kazuyuki Kominami, Yuri Ushio, Hideki Cervancia, Cleofas Estacio, Maria Amelita Kyuwa, Shigeru Kakuta, Shigeru Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, there is no effective treatment for hair loss. It is known that honeybee propolis has various biological activities, including stimulating the proliferation of hair matrix keratinocytes. However, little is known with the hair promoting activity of stingless bee propolis. Hence, this study investigates the hair growth-promoting activity of Philippines stingless bee propolis extract and the underlying a molecular mechanism of promoting hair growth. For the evaluation of hair growth stimulating activity, 99.5% ethanolic extract of Philippines stingless bee propolis is examined using the simple shaving model in C57BL/6N mice. Melaninization of dorsal skin and histological analysis of hair follicles (HFs) revealed that propolis promotes hair growth by stimulating HFs development. The expression of mRNA (Wnt3a, Ctnnb1/β-catenin, Lef1, and Bmp2) and protein (WNT3A and β-catenin) of selected Wnt/β-catenin associated genes explains Philippines stingless bee propolis promoting HFs development by activating Wnt/β-catenin signaling pathway. These results suggest that the treatment of propolis strongly promotes hair growth by stimulating the development of HFs via activation of Wnt/β-catenin signaling pathway. This further indicates the potential of Philippines stingless bee propolis as a novel promising agricultural product for hair growth. J-Stage 2022 Article PeerReviewed Tang, Yulan and Wang, Chen and Desamero, Mark Joseph M. and Mun, Keong Kok and Chambers, James Kenn and Uchida, Kazuyuki and Kominami, Yuri and Ushio, Hideki and Cervancia, Cleofas and Estacio, Maria Amelita and Kyuwa, Shigeru and Kakuta, Shigeru (2022) The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway. Experimental Animals, 72 (1). pp. 132-139. ISSN 1341-1357 https://www.jstage.jst.go.jp/article/expanim/72/1/72_22-0092/_article 10.1538/expanim.22-0092 |
| spellingShingle | Tang, Yulan Wang, Chen Desamero, Mark Joseph M. Mun, Keong Kok Chambers, James Kenn Uchida, Kazuyuki Kominami, Yuri Ushio, Hideki Cervancia, Cleofas Estacio, Maria Amelita Kyuwa, Shigeru Kakuta, Shigeru The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title | The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title_full | The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title_fullStr | The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title_full_unstemmed | The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title_short | The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway |
| title_sort | philippines stingless bee propolis promotes hair growth through activation of wnt/β-catenin signaling pathway |
| url | http://psasir.upm.edu.my/id/eprint/103664/ http://psasir.upm.edu.my/id/eprint/103664/ http://psasir.upm.edu.my/id/eprint/103664/ |