The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia
This study aimed to investigate the association between particulate PAHs exposure and DNA damage in Malaysian schoolchildren in heavy traffic (HT) and low traffic (LT) areas. PAH samples at eight schools were collected using a low volume sampler for 24 h and quantified using Gas Chromatography-Mass...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/103601/ |
| _version_ | 1848864061106683904 |
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| author | Hisamuddin, Nur Hazirah Jalaludin, Juliana Abu Bakar, Suhaili Latif, Mohd Talib |
| author_facet | Hisamuddin, Nur Hazirah Jalaludin, Juliana Abu Bakar, Suhaili Latif, Mohd Talib |
| author_sort | Hisamuddin, Nur Hazirah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study aimed to investigate the association between particulate PAHs exposure and DNA damage in Malaysian schoolchildren in heavy traffic (HT) and low traffic (LT) areas. PAH samples at eight schools were collected using a low volume sampler for 24 h and quantified using Gas Chromatography-Mass Spectrometry. Two hundred and twenty-eight buccal cells of children were assessed for DNA damage using Comet Assay. Monte-Carlo simulation was performed to determine incremental lifetime cancer risk (ILCR) and to check the uncertainty and sensitivity of the estimated risk. Total PAH concentrations in the schools in HT area were higher than LT area ranging from 4.4 to 5.76 ng m−3 and 1.36 to 3.79 ng m−3, respectively. The source diagnostic ratio showed that PAHs in the HT area is pyrogenic, mainly from diesel emission. The 95th percentile of the ILCR for children in HT and LT area were 2.80 × 10−7 and 1.43 × 10−7, respectively. The degree of DNA damage was significantly more severe in children in the HT group compared to LT group. This study shows that total indoor PAH exposure was the most significant factor that influenced the DNA damage among children. Further investigation of the relationship between PAH exposure and genomic integrity in children is required to shed additional light on potential health risks. |
| first_indexed | 2025-11-15T13:42:49Z |
| format | Article |
| id | upm-103601 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:42:49Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1036012023-05-16T07:39:06Z http://psasir.upm.edu.my/id/eprint/103601/ The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia Hisamuddin, Nur Hazirah Jalaludin, Juliana Abu Bakar, Suhaili Latif, Mohd Talib This study aimed to investigate the association between particulate PAHs exposure and DNA damage in Malaysian schoolchildren in heavy traffic (HT) and low traffic (LT) areas. PAH samples at eight schools were collected using a low volume sampler for 24 h and quantified using Gas Chromatography-Mass Spectrometry. Two hundred and twenty-eight buccal cells of children were assessed for DNA damage using Comet Assay. Monte-Carlo simulation was performed to determine incremental lifetime cancer risk (ILCR) and to check the uncertainty and sensitivity of the estimated risk. Total PAH concentrations in the schools in HT area were higher than LT area ranging from 4.4 to 5.76 ng m−3 and 1.36 to 3.79 ng m−3, respectively. The source diagnostic ratio showed that PAHs in the HT area is pyrogenic, mainly from diesel emission. The 95th percentile of the ILCR for children in HT and LT area were 2.80 × 10−7 and 1.43 × 10−7, respectively. The degree of DNA damage was significantly more severe in children in the HT group compared to LT group. This study shows that total indoor PAH exposure was the most significant factor that influenced the DNA damage among children. Further investigation of the relationship between PAH exposure and genomic integrity in children is required to shed additional light on potential health risks. Multidisciplinary Digital Publishing Institute 2022 Article PeerReviewed Hisamuddin, Nur Hazirah and Jalaludin, Juliana and Abu Bakar, Suhaili and Latif, Mohd Talib (2022) The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia. International Journal of Environmental Research and Public Health, 19 (4). art. no. 2193. pp. 1-20. ISSN 1660-4601 https://www.mdpi.com/1660-4601/19/4/2193 10.3390/ijerph19042193 |
| spellingShingle | Hisamuddin, Nur Hazirah Jalaludin, Juliana Abu Bakar, Suhaili Latif, Mohd Talib The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title | The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title_full | The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title_fullStr | The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title_full_unstemmed | The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title_short | The influence of environmental Polycyclic Aromatic Hydrocarbons (PAHs) exposure on DNA damage among school children in urban traffic area, Malaysia |
| title_sort | influence of environmental polycyclic aromatic hydrocarbons (pahs) exposure on dna damage among school children in urban traffic area, malaysia |
| url | http://psasir.upm.edu.my/id/eprint/103601/ http://psasir.upm.edu.my/id/eprint/103601/ http://psasir.upm.edu.my/id/eprint/103601/ |