The impact of cycleanine in cancer research: a computational study

QR Code

The impact of cycleanine in cancer research: a computational study

Cancer is imposing a global health burden because of the steady increase in new cases. Moreover, current anticancer therapeutics are associated with many drawbacks, mainly the emergence of resistance and the severe adverse effects. Therefore, there is a continuous need for developing new anticancer...

Full description

Bibliographic Details
Main Authors:	Nwaefulu, Ogochukwu Ngozi, Al-Shar'i, Nizar A, Owolabi, Josephine Omonkhelin, Sagineedu, Sreenivasa Rao, Lim, Chee Woei, Lam, Kok Wai, Islam, Mohammad Kaisarul, Jayanthi, Sivaraman, Stanslas, Johnson
Format:	Article
Published:	Springer 2022
Online Access:	http://psasir.upm.edu.my/id/eprint/103575/

Similar Items

Pancreatic cancer treatment with targeted therapies: are we there yet
by: Nwaefulu, O. Ngozi, et al.
Published: (2022)

Ethnobotanical study of anticancer plants used in Ugbine, Nigeria and bioactivity-guided isolation of cytotoxic agents from Synclisia scabrida (Miers) ex oliv
by: Ngozi, Nwaefulu Ogochukwu
Published: (2022)

Pharmacological modulation of apoptosis and autophagy in pancreatic cancer treatment
by: Stanslas, Johnson, et al.
Published: (2022)

SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line
by: Lim, Jonathan Chee Woei, et al.
Published: (2015)

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review
by: Bagalkotkar, Gururaj, et al.
Published: (2006)

Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
by: Soo, Hon Liong, et al.
Published: (2019)

Peptide-based and small molecule PD-1 and PD-L1 pharmacological modulators in the treatment of cancer
by: Islam, Mohammad Kaisarul, et al.
Published: (2021)

Melanoma metastasis: what role does melanin play? (review)
by: Saud, Anoosha, et al.
Published: (2022)

More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro
by: Yuan, Han Teh, et al.
Published: (2023)

Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets
by: Stanslas, Johnson, et al.
Published: (2010)

SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
by: Wong, Charng Choon, et al.
Published: (2016)

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
by: Wong, Hui Chyn, et al.
Published: (2014)

Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?
by: Hamdi, Amir Imran Faisal, et al.
Published: (2022)

In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein
by: Shun, Ying Quah, et al.
Published: (2020)

Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
by: Shun, Ying Quah, et al.
Published: (2021)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide
by: Wong, Charng Choon, et al.
Published: (2014)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
by: Wong, Charng Choon, et al.
Published: (2014)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
by: Hocker, Harrison J., et al.
Published: (2013)

Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation
by: Sulaiman, Ibrahim, et al.
Published: (2016)

Molecular and immunomodulatory actions of new antiasthmatic agents: exploring the diversity of biologics in Th2 endotype asthma
by: Okwuofu, Emmanuel Oshiogwe, et al.
Published: (2022)

A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata nees
by: Valdiani, Alireza, et al.
Published: (2014)

Andrographolide restores healthy airway function in toluene diisocyanate-induced occupational mouse asthma model through upregulation of heam oxygenase-1 and activation of Akt/Nrf-2 dependent pathway
by: Sulaiman, Ibrahim, et al.
Published: (2017)

Institusi pengajian tinggi swasta di Malaysia : isu-isu terbabit serta cabaran-cabaran yang dihadapi / Sivaraman a/l Mathavan.
by: Mathavan, Sivaraman
Published: (2004)

Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines
by: Khor, Poh Yen, et al.
Published: (2021)

An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice
by: Sulaiman, Ibrahim, et al.
Published: (2024)

Modem Recognition Algorithm for Software Defined Radio Base Station
by: Rukumangatha Rajah, Sivaraman
Published: (2004)

Risk Mitigation Of Outsourcing Manufacturing Process: A Study On The Semiconductor Manufacturing Organizations In Malaysia
by: Rukumangatha Rajah, Sivaraman
Published: (2012)

The Synthesis and Bioactivity of 2,6-Bisbenzylidenecyclohexanone, Pyrazoline, Chalcone and Oxadiazole Derivatives and Computational Studies on Some of These Compounds
by: Lam, Kok Wai
Published: (2010)

Synthesis of damnacanthal, a naturally occurring 9,10-anthraquinone and its analogues, and its biological evaluation against five cancer cell lines.
by: Saha, Koushik, et al.
Published: (2013)

Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway
by: Huq, AKM Moyeenul, et al.
Published: (2019)

Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ERα-mediated pathway
by: Huq, Akm Moyeenul, et al.
Published: (2019)

Ethics of human embryonic stem cell research: The perception of Buddhist, Hindu and Catholic representatives in Malaysia / Mathana Amaris Fiona Sivaraman
by: Mathana Amaris Fiona, Sivaraman
Published: (2016)

Structural and pain modifications in models of osteoarthritis
by: Nwosu, Lilian Ngozi
Published: (2015)

Examining the Impact of Trust on Social Media Networks (A study on people living in Malaysia)
by: Onyemeh, Ngozi Celestina
Published: (2011)

Novel co-precipitated oxygen carriers for chemical looping combustion of gaseous fuel
by: Ekpe, Ngozi Chinwe
Published: (2017)

Impact of employee psychological empowerment, process and equipment on operational service quality in the oilfield service industry
by: Onyemeh, Ngozi C.
Published: (2017)

The impact of disadvantage on the learning of mathematics: a study of pupils’ experiences in low attaining groups
by: Nwabuikwu, Stephanie Ngozi
Published: (2018)

Advances in psoriasis research: from pathogenesis to therapeutics
by: Sugumaran, Dineshwar, et al.
Published: (2024)

Prevalence of macrolide resistance and in vitro activities of six antimicrobial agents against clinical isolates of streptococcus pneumoniae from a multi-center surveillance in Malaysia
by: Jeevajothi Nathan, Jayakayatri, et al.
Published: (2013)