The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review
In the vascular wall, defence against pathogenic damage requires a group of monocytes, the endothelium, dendritic cells, macrophages and a subsequent involvement of pattern recognition receptors anticipating damage-associated molecular patterns (DAMPs) to initiate an innate immune response. The endo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Universiti Sains Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/103554/ |
| _version_ | 1848864048112730112 |
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| author | Abas, Razif Basir, Rusliza Mohd Thani, Suryati Salihan, Safuraa Saat, Azmah Mohamad Zainal, Nurul Hayati Mohamad Asri, Siti Fadziyah Ab Razak, Nur Izah Mohd Nor, Nurul Huda Kamaruddin, Nur Aqilah |
| author_facet | Abas, Razif Basir, Rusliza Mohd Thani, Suryati Salihan, Safuraa Saat, Azmah Mohamad Zainal, Nurul Hayati Mohamad Asri, Siti Fadziyah Ab Razak, Nur Izah Mohd Nor, Nurul Huda Kamaruddin, Nur Aqilah |
| author_sort | Abas, Razif |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In the vascular wall, defence against pathogenic damage requires a group of monocytes, the endothelium, dendritic cells, macrophages and a subsequent involvement of pattern recognition receptors anticipating damage-associated molecular patterns (DAMPs) to initiate an innate immune response. The endothelium plays a crucial role in regulating the duration, location and extent of the inflammatory cascade to ensure a definitive immune defence. Molecular changes in the expression of chemokines and cell adhesion molecules ensure protective responses against infection and injury. The multiprotein oligomer complex nucleotide-binding oligomerisation domain (NOD)-like receptor pyrin domain 3 (NLRP3) inflammasome plays a key role in the activation of inflammatory processes in response to DAMPs and pattern-associated molecular patterns. As a result of NLRP3 inflammasome activation, caspase-1 is activated and interleukin-1β (IL-1β) is produced. Caspase-1 is the main mediator of inflammatory feedback to tissue injury, and it is engaged both in the initiation of the inflammatory response and in the induction of cell death. NLRP3 inflammasome promotes further inflammatory responses and pyroptosis in the vascular endothelium; thus, its optimum regulation is crucial in cardiovascular homeostasis. This review outlines our current perception of the role of NLRP3 in vascular endothelial cells. |
| first_indexed | 2025-11-15T13:42:37Z |
| format | Article |
| id | upm-103554 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:42:37Z |
| publishDate | 2022 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1035542023-05-18T04:30:14Z http://psasir.upm.edu.my/id/eprint/103554/ The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review Abas, Razif Basir, Rusliza Mohd Thani, Suryati Salihan, Safuraa Saat, Azmah Mohamad Zainal, Nurul Hayati Mohamad Asri, Siti Fadziyah Ab Razak, Nur Izah Mohd Nor, Nurul Huda Kamaruddin, Nur Aqilah In the vascular wall, defence against pathogenic damage requires a group of monocytes, the endothelium, dendritic cells, macrophages and a subsequent involvement of pattern recognition receptors anticipating damage-associated molecular patterns (DAMPs) to initiate an innate immune response. The endothelium plays a crucial role in regulating the duration, location and extent of the inflammatory cascade to ensure a definitive immune defence. Molecular changes in the expression of chemokines and cell adhesion molecules ensure protective responses against infection and injury. The multiprotein oligomer complex nucleotide-binding oligomerisation domain (NOD)-like receptor pyrin domain 3 (NLRP3) inflammasome plays a key role in the activation of inflammatory processes in response to DAMPs and pattern-associated molecular patterns. As a result of NLRP3 inflammasome activation, caspase-1 is activated and interleukin-1β (IL-1β) is produced. Caspase-1 is the main mediator of inflammatory feedback to tissue injury, and it is engaged both in the initiation of the inflammatory response and in the induction of cell death. NLRP3 inflammasome promotes further inflammatory responses and pyroptosis in the vascular endothelium; thus, its optimum regulation is crucial in cardiovascular homeostasis. This review outlines our current perception of the role of NLRP3 in vascular endothelial cells. Universiti Sains Malaysia 2022 Article PeerReviewed Abas, Razif and Basir, Rusliza and Mohd Thani, Suryati and Salihan, Safuraa and Saat, Azmah and Mohamad Zainal, Nurul Hayati and Mohamad Asri, Siti Fadziyah and Ab Razak, Nur Izah and Mohd Nor, Nurul Huda and Kamaruddin, Nur Aqilah (2022) The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review. Malaysian Journal of Medical Sciences, 29 (2). pp. 8-17. ISSN 1394-195X https://pubmed.ncbi.nlm.nih.gov/35528818/ 10.21315/mjms2022.29.2.2 |
| spellingShingle | Abas, Razif Basir, Rusliza Mohd Thani, Suryati Salihan, Safuraa Saat, Azmah Mohamad Zainal, Nurul Hayati Mohamad Asri, Siti Fadziyah Ab Razak, Nur Izah Mohd Nor, Nurul Huda Kamaruddin, Nur Aqilah The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title | The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title_full | The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title_fullStr | The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title_full_unstemmed | The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title_short | The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review |
| title_sort | evolving role of nucleotide-binding oligomerisation domain-like receptor pyrin domain 3 inflammasome activation in vascular endothelial cells: a review |
| url | http://psasir.upm.edu.my/id/eprint/103554/ http://psasir.upm.edu.my/id/eprint/103554/ http://psasir.upm.edu.my/id/eprint/103554/ |