Rhogas role in t cell activation and function
The role of RhoG in T cell development is redundant with other Racs subfamily members, and this redundancy may be attributed to redundant signal transduction pathways. However, the absence of RhoG increases TCR signalling and proliferation, implying that RhoG activity is critical during late T cell...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/103098/ http://psasir.upm.edu.my/id/eprint/103098/1/103098.pdf |
| _version_ | 1848863935368790016 |
|---|---|
| author | Ahmad Mokhtar, Ana Masara Salikin, Nor Hawani Haron, Aminah Suhaila Amin-Nordin, Syafinaz Hashim, Ilie Fadzilah Mohd Zaini Makhtar, Muaz Zulfigar, Siti Balqis Ismail, Nurul Izza |
| author_facet | Ahmad Mokhtar, Ana Masara Salikin, Nor Hawani Haron, Aminah Suhaila Amin-Nordin, Syafinaz Hashim, Ilie Fadzilah Mohd Zaini Makhtar, Muaz Zulfigar, Siti Balqis Ismail, Nurul Izza |
| author_sort | Ahmad Mokhtar, Ana Masara |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The role of RhoG in T cell development is redundant with other Racs subfamily members, and this redundancy may be attributed to redundant signal transduction pathways. However, the absence of RhoG increases TCR signalling and proliferation, implying that RhoG activity is critical during late T cell activation following antigen–receptor interaction. Moreover, RhoG is required to halt signal transduction and prevent hyper-activated T cells. Despite increase in TCR signalling, cell proliferation is inhibited, implying that RhoG induces T cell anergy by promoting the activities of transcription factors, including nuclear factor of activated T cell (NFAT)/AP-1. The role of NFAT plays in T cell anergy is inducing the transcription of anergy-associated genes, such as IL-2, IL-5, and IFN-γ. Although information about RhoG in T cell-related diseases is limited, mutant forms of RhoG, Ala151Ser and Glu171Lys have been observed in thymoma and hemophagocytic lymphohistiocytosis (HLH), respectively. Current information only focuses on these two diseases, and thus the role of RhoG in normal and pathological circumstances should be further investigated. This approach is necessary because RhoG and its associated proteins represent prospective targets for attack particularly in the therapy of cancer and immune-mediated illnesses. |
| first_indexed | 2025-11-15T13:40:49Z |
| format | Article |
| id | upm-103098 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:40:49Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1030982024-11-20T07:34:30Z http://psasir.upm.edu.my/id/eprint/103098/ Rhogas role in t cell activation and function Ahmad Mokhtar, Ana Masara Salikin, Nor Hawani Haron, Aminah Suhaila Amin-Nordin, Syafinaz Hashim, Ilie Fadzilah Mohd Zaini Makhtar, Muaz Zulfigar, Siti Balqis Ismail, Nurul Izza The role of RhoG in T cell development is redundant with other Racs subfamily members, and this redundancy may be attributed to redundant signal transduction pathways. However, the absence of RhoG increases TCR signalling and proliferation, implying that RhoG activity is critical during late T cell activation following antigen–receptor interaction. Moreover, RhoG is required to halt signal transduction and prevent hyper-activated T cells. Despite increase in TCR signalling, cell proliferation is inhibited, implying that RhoG induces T cell anergy by promoting the activities of transcription factors, including nuclear factor of activated T cell (NFAT)/AP-1. The role of NFAT plays in T cell anergy is inducing the transcription of anergy-associated genes, such as IL-2, IL-5, and IFN-γ. Although information about RhoG in T cell-related diseases is limited, mutant forms of RhoG, Ala151Ser and Glu171Lys have been observed in thymoma and hemophagocytic lymphohistiocytosis (HLH), respectively. Current information only focuses on these two diseases, and thus the role of RhoG in normal and pathological circumstances should be further investigated. This approach is necessary because RhoG and its associated proteins represent prospective targets for attack particularly in the therapy of cancer and immune-mediated illnesses. Frontiers Media 2022 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/103098/1/103098.pdf Ahmad Mokhtar, Ana Masara and Salikin, Nor Hawani and Haron, Aminah Suhaila and Amin-Nordin, Syafinaz and Hashim, Ilie Fadzilah and Mohd Zaini Makhtar, Muaz and Zulfigar, Siti Balqis and Ismail, Nurul Izza (2022) Rhogas role in t cell activation and function. Frontiers in Immunology, 13. art. no. 845064. pp. 1-7. ISSN 1664-3224 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.845064/full 10.3389/fimmu.2022.845064 |
| spellingShingle | Ahmad Mokhtar, Ana Masara Salikin, Nor Hawani Haron, Aminah Suhaila Amin-Nordin, Syafinaz Hashim, Ilie Fadzilah Mohd Zaini Makhtar, Muaz Zulfigar, Siti Balqis Ismail, Nurul Izza Rhogas role in t cell activation and function |
| title | Rhogas role in t cell activation and function |
| title_full | Rhogas role in t cell activation and function |
| title_fullStr | Rhogas role in t cell activation and function |
| title_full_unstemmed | Rhogas role in t cell activation and function |
| title_short | Rhogas role in t cell activation and function |
| title_sort | rhogas role in t cell activation and function |
| url | http://psasir.upm.edu.my/id/eprint/103098/ http://psasir.upm.edu.my/id/eprint/103098/ http://psasir.upm.edu.my/id/eprint/103098/ http://psasir.upm.edu.my/id/eprint/103098/1/103098.pdf |