Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons
Pneumonic mannheimiosis is well documented in the literature focusing on the respiratory system of small ruminants from clinical and research perspectives. However, there is still a lack of understanding of this disease’s pathophysiological changes and impact on the reproductive system of affected a...
| Main Authors: | , , , , , , |
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| Format: | Article |
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ResearchersLinks
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/103070/ |
| _version_ | 1848863929661390848 |
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| author | Maqbool, Arsalan Jesse, Faez Firdaus Abdullah Lim, Eric Teik Chung Haron, Abd Wahid Mohd Lila, Mohd Azmi Paul, Bura Thlama Bhutto, Khaliq Ur Rehman |
| author_facet | Maqbool, Arsalan Jesse, Faez Firdaus Abdullah Lim, Eric Teik Chung Haron, Abd Wahid Mohd Lila, Mohd Azmi Paul, Bura Thlama Bhutto, Khaliq Ur Rehman |
| author_sort | Maqbool, Arsalan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Pneumonic mannheimiosis is well documented in the literature focusing on the respiratory system of small ruminants from clinical and research perspectives. However, there is still a lack of understanding of this disease’s pathophysiological changes and impact on the reproductive system of affected animals. Therefore, the purpose of this study was to examine at the reproductive hormonal profile of female goats experimentally infected with Mannheimia haemolytica serotype A2 during rainy and hot seasons. Twenty-four healthy female, non-pregnant does were used, and divided into two equal groups, 12 does were further allocated into 3 groups (n=4), control, non-vaccinated and vaccinated in each season. After acclimatization and synchronization procedure, the vaccinated group was administered with 2 mL of alum-precipitated pasteurellosis vaccine while non-vaccinated and control groups were administered with 2 mL of phosphate-buffered saline (PBS) via the intramuscular route. At week 2, both non-vaccinated and the vaccinated groups were challenged intranasally with 2 mL of bacterial cell suspension containing 105 colony-forming unit (CFU) of M. haemolytica serotype A2. Blood samples were collected on weekly basis. The results revealed that the plasma progesterone concentration increased significantly (p<0.05) whereas estrogen, follicle-stimulating hormone and luteinizing hormone decreased significantly (p<0.05) in the non-vaccinated group compared to vaccinated and control groups in both seasons. The study outcomes shown that climate has neither significant effect on reproductive physiology nor exaggerated the effect on an experimentally infected animal. Furthermore, it is concluded that pneumonic mannheimiosis causes a negative impact on reproductive performance of the female goats where hormonal imbalances were observed which may result to pseudopregnancy or infertility in does infected with M. haemolytica serotype A2. |
| first_indexed | 2025-11-15T13:40:44Z |
| format | Article |
| id | upm-103070 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:40:44Z |
| publishDate | 2022 |
| publisher | ResearchersLinks |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1030702024-06-30T15:37:34Z http://psasir.upm.edu.my/id/eprint/103070/ Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons Maqbool, Arsalan Jesse, Faez Firdaus Abdullah Lim, Eric Teik Chung Haron, Abd Wahid Mohd Lila, Mohd Azmi Paul, Bura Thlama Bhutto, Khaliq Ur Rehman Pneumonic mannheimiosis is well documented in the literature focusing on the respiratory system of small ruminants from clinical and research perspectives. However, there is still a lack of understanding of this disease’s pathophysiological changes and impact on the reproductive system of affected animals. Therefore, the purpose of this study was to examine at the reproductive hormonal profile of female goats experimentally infected with Mannheimia haemolytica serotype A2 during rainy and hot seasons. Twenty-four healthy female, non-pregnant does were used, and divided into two equal groups, 12 does were further allocated into 3 groups (n=4), control, non-vaccinated and vaccinated in each season. After acclimatization and synchronization procedure, the vaccinated group was administered with 2 mL of alum-precipitated pasteurellosis vaccine while non-vaccinated and control groups were administered with 2 mL of phosphate-buffered saline (PBS) via the intramuscular route. At week 2, both non-vaccinated and the vaccinated groups were challenged intranasally with 2 mL of bacterial cell suspension containing 105 colony-forming unit (CFU) of M. haemolytica serotype A2. Blood samples were collected on weekly basis. The results revealed that the plasma progesterone concentration increased significantly (p<0.05) whereas estrogen, follicle-stimulating hormone and luteinizing hormone decreased significantly (p<0.05) in the non-vaccinated group compared to vaccinated and control groups in both seasons. The study outcomes shown that climate has neither significant effect on reproductive physiology nor exaggerated the effect on an experimentally infected animal. Furthermore, it is concluded that pneumonic mannheimiosis causes a negative impact on reproductive performance of the female goats where hormonal imbalances were observed which may result to pseudopregnancy or infertility in does infected with M. haemolytica serotype A2. ResearchersLinks 2022-09 Article PeerReviewed Maqbool, Arsalan and Jesse, Faez Firdaus Abdullah and Lim, Eric Teik Chung and Haron, Abd Wahid and Mohd Lila, Mohd Azmi and Paul, Bura Thlama and Bhutto, Khaliq Ur Rehman (2022) Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons. Journal of Animal Health and Production, 10 (3). pp. 352-359. ISSN 2308-2801 https://researcherslinks.com/current-issues/Response-of-Reproductive-Hormones-in-Vaccinated-and-Non-Vaccinated-Pneumonic-Female-Goats-Via-Experimental-Infection-of-Mannheimia-haemolytica-Serotype-A2-Under-Rainy-and-Hot-Seasons/34/1/5213/html 10.17582/journal.jahp/2022/10.3.352.359 |
| spellingShingle | Maqbool, Arsalan Jesse, Faez Firdaus Abdullah Lim, Eric Teik Chung Haron, Abd Wahid Mohd Lila, Mohd Azmi Paul, Bura Thlama Bhutto, Khaliq Ur Rehman Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title | Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title_full | Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title_fullStr | Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title_full_unstemmed | Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title_short | Response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of Mannheimia haemolytica serotype A2 under rainy and hot seasons |
| title_sort | response of reproductive hormones in vaccinated and non-vaccinated pneumonic female goats via experimental infection of mannheimia haemolytica serotype a2 under rainy and hot seasons |
| url | http://psasir.upm.edu.my/id/eprint/103070/ http://psasir.upm.edu.my/id/eprint/103070/ http://psasir.upm.edu.my/id/eprint/103070/ |