Recent advances in the therapeutic strategies of glioblastoma multiforme
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest malignant types of primary astrocytoma with a poor prognosis. At present, the standard of care includes surgical tumor resection, followed by radiation therapy concomitant with chemotherapy and temozolomide. New...
| Main Authors: | , , , , |
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| Format: | Article |
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Elsevier
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/103004/ |
| _version_ | 1848863915893587968 |
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| author | Aldoghachi, Asraa Faris Aldoghachi, Ahmed Faris Breyne, Koen Ling, King-Hwa Cheah, Pike-See |
| author_facet | Aldoghachi, Asraa Faris Aldoghachi, Ahmed Faris Breyne, Koen Ling, King-Hwa Cheah, Pike-See |
| author_sort | Aldoghachi, Asraa Faris |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest malignant types of primary astrocytoma with a poor prognosis. At present, the standard of care includes surgical tumor resection, followed by radiation therapy concomitant with chemotherapy and temozolomide. New developments and significant advances in the treatment of GBM have been achieved in recent decades. However, despite the advances, recurrence is often inevitable, and the survival of patients remains low. Various factors contribute to the difficulty in identifying an effective therapeutic option, among which are tumor complexity, the presence of the blood–brain barrier (BBB), and the presence of GBM cancer stem cells, prompting the need for improving existing treatment approaches and investigating new treatment alternatives for ameliorating the treatment strategies of GBM. In this review, we outline some of the most recent literature on the various available treatment options such as surgery, radiotherapy, cytotoxic chemotherapy, gene therapy, immunotherapy, phototherapy, nanotherapy, and tumor treating fields in the treatment of GBM, and we list some of the potential future directions of GBM. The reviewed studies confirm that GBM is a sophisticated disease with several challenges for scientists to address. Hence, more studies and a multimodal therapeutic approach are crucial to yield an effective cure and prolong the survival of GBM patients. |
| first_indexed | 2025-11-15T13:40:31Z |
| format | Article |
| id | upm-103004 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:40:31Z |
| publishDate | 2022 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1030042024-06-30T07:03:42Z http://psasir.upm.edu.my/id/eprint/103004/ Recent advances in the therapeutic strategies of glioblastoma multiforme Aldoghachi, Asraa Faris Aldoghachi, Ahmed Faris Breyne, Koen Ling, King-Hwa Cheah, Pike-See Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest malignant types of primary astrocytoma with a poor prognosis. At present, the standard of care includes surgical tumor resection, followed by radiation therapy concomitant with chemotherapy and temozolomide. New developments and significant advances in the treatment of GBM have been achieved in recent decades. However, despite the advances, recurrence is often inevitable, and the survival of patients remains low. Various factors contribute to the difficulty in identifying an effective therapeutic option, among which are tumor complexity, the presence of the blood–brain barrier (BBB), and the presence of GBM cancer stem cells, prompting the need for improving existing treatment approaches and investigating new treatment alternatives for ameliorating the treatment strategies of GBM. In this review, we outline some of the most recent literature on the various available treatment options such as surgery, radiotherapy, cytotoxic chemotherapy, gene therapy, immunotherapy, phototherapy, nanotherapy, and tumor treating fields in the treatment of GBM, and we list some of the potential future directions of GBM. The reviewed studies confirm that GBM is a sophisticated disease with several challenges for scientists to address. Hence, more studies and a multimodal therapeutic approach are crucial to yield an effective cure and prolong the survival of GBM patients. Elsevier 2022 Article PeerReviewed Aldoghachi, Asraa Faris and Aldoghachi, Ahmed Faris and Breyne, Koen and Ling, King-Hwa and Cheah, Pike-See (2022) Recent advances in the therapeutic strategies of glioblastoma multiforme. Neuroscience, 491. pp. 240-270. ISSN 0306-4522 https://linkinghub.elsevier.com/retrieve/pii/S0306452222001555 10.1016/j.neuroscience.2022.03.030 |
| spellingShingle | Aldoghachi, Asraa Faris Aldoghachi, Ahmed Faris Breyne, Koen Ling, King-Hwa Cheah, Pike-See Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title | Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title_full | Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title_fullStr | Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title_full_unstemmed | Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title_short | Recent advances in the therapeutic strategies of glioblastoma multiforme |
| title_sort | recent advances in the therapeutic strategies of glioblastoma multiforme |
| url | http://psasir.upm.edu.my/id/eprint/103004/ http://psasir.upm.edu.my/id/eprint/103004/ http://psasir.upm.edu.my/id/eprint/103004/ |