Pasteurellosis vaccine commercialization: physiochemical factors for optimum production
Pasteurella spp. are Gram-negative facultative bacteria that cause severe economic and animal losses. Pasteurella-based vaccines are the most promising solution for controlling Pasteurella spp. outbreaks. Remarkably, insufficient biomass cultivation (low cell viability and productivity) and lack of...
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| Format: | Article |
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MDPI
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102668/ |
| _version_ | 1848863854731198464 |
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| author | Oslan, Siti Nur Hazwani Tan, Joo Shun Yusoff, Abdul Hafidz Sulaiman, Ahmad Ziad |
| author_facet | Oslan, Siti Nur Hazwani Tan, Joo Shun Yusoff, Abdul Hafidz Sulaiman, Ahmad Ziad |
| author_sort | Oslan, Siti Nur Hazwani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Pasteurella spp. are Gram-negative facultative bacteria that cause severe economic and animal losses. Pasteurella-based vaccines are the most promising solution for controlling Pasteurella spp. outbreaks. Remarkably, insufficient biomass cultivation (low cell viability and productivity) and lack of knowledge about the cultivation process have impacted the bulk production of animal vaccines. Bioprocess optimization in the shake flask and bioreactor is required to improve process efficiency while lowering production costs. However, its state of the art is limited in providing insights on its biomass upscaling, preventing a cost-effective vaccine with mass-produced bacteria from being developed. In general, in the optimum cultivation of Pasteurella spp., production factors such as pH (6.0–8.2), agitation speed (90–500 rpm), and temperature (35–40 °C) are used to improve production yield. Hence, this review discusses the production strategy of Pasteurella and Mannheimia species that can potentially be used in the vaccines for controlling pasteurellosis. The physicochemical factors related to operational parameter process conditions from a bioprocess engineering perspective that maximize yields with minimized production cost are also covered, with the expectation of facilitating the commercialization process. |
| first_indexed | 2025-11-15T13:39:32Z |
| format | Article |
| id | upm-102668 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:39:32Z |
| publishDate | 2022 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1026682024-06-22T13:07:41Z http://psasir.upm.edu.my/id/eprint/102668/ Pasteurellosis vaccine commercialization: physiochemical factors for optimum production Oslan, Siti Nur Hazwani Tan, Joo Shun Yusoff, Abdul Hafidz Sulaiman, Ahmad Ziad Pasteurella spp. are Gram-negative facultative bacteria that cause severe economic and animal losses. Pasteurella-based vaccines are the most promising solution for controlling Pasteurella spp. outbreaks. Remarkably, insufficient biomass cultivation (low cell viability and productivity) and lack of knowledge about the cultivation process have impacted the bulk production of animal vaccines. Bioprocess optimization in the shake flask and bioreactor is required to improve process efficiency while lowering production costs. However, its state of the art is limited in providing insights on its biomass upscaling, preventing a cost-effective vaccine with mass-produced bacteria from being developed. In general, in the optimum cultivation of Pasteurella spp., production factors such as pH (6.0–8.2), agitation speed (90–500 rpm), and temperature (35–40 °C) are used to improve production yield. Hence, this review discusses the production strategy of Pasteurella and Mannheimia species that can potentially be used in the vaccines for controlling pasteurellosis. The physicochemical factors related to operational parameter process conditions from a bioprocess engineering perspective that maximize yields with minimized production cost are also covered, with the expectation of facilitating the commercialization process. MDPI 2022 Article PeerReviewed Oslan, Siti Nur Hazwani and Tan, Joo Shun and Yusoff, Abdul Hafidz and Sulaiman, Ahmad Ziad (2022) Pasteurellosis vaccine commercialization: physiochemical factors for optimum production. Molecular Diversity Preservation International MDPI, 10 (7). art. no. 1248. pp. 1-15. ISSN 2227-9717 https://www.mdpi.com/2227-9717/10/7/1248 10.3390/pr10071248 |
| spellingShingle | Oslan, Siti Nur Hazwani Tan, Joo Shun Yusoff, Abdul Hafidz Sulaiman, Ahmad Ziad Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title | Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title_full | Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title_fullStr | Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title_full_unstemmed | Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title_short | Pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| title_sort | pasteurellosis vaccine commercialization: physiochemical factors for optimum production |
| url | http://psasir.upm.edu.my/id/eprint/102668/ http://psasir.upm.edu.my/id/eprint/102668/ http://psasir.upm.edu.my/id/eprint/102668/ |