Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats
This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin w...
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| Format: | Article |
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Hindawi
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102658/ |
| _version_ | 1848863851665162240 |
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| author | Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Mohd Noor, Mohd Hezmee |
| author_facet | Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Mohd Noor, Mohd Hezmee |
| author_sort | Albaayit, Shaymaa Fadhel Abbas |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 β (IL-1β), and tumor necrosis factor-α (TNF-α), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its anti-inflammatory, antioxidant, and tissue repair activities. |
| first_indexed | 2025-11-15T13:39:29Z |
| format | Article |
| id | upm-102658 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:39:29Z |
| publishDate | 2022 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1026582023-07-18T03:42:13Z http://psasir.upm.edu.my/id/eprint/102658/ Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Mohd Noor, Mohd Hezmee This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 β (IL-1β), and tumor necrosis factor-α (TNF-α), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its anti-inflammatory, antioxidant, and tissue repair activities. Hindawi 2022-09-10 Article PeerReviewed Albaayit, Shaymaa Fadhel Abbas and Abdullah, Rasedee and Mohd Noor, Mohd Hezmee (2022) Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats. BioMed Research International, 2022. pp. 1-11. ISSN 2314-6133; ESSN: 2314-6141 https://www.hindawi.com/journals/bmri/ 10.1155/2022/1129297 |
| spellingShingle | Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Mohd Noor, Mohd Hezmee Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title | Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title_full | Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title_fullStr | Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title_full_unstemmed | Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title_short | Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| title_sort | zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
| url | http://psasir.upm.edu.my/id/eprint/102658/ http://psasir.upm.edu.my/id/eprint/102658/ http://psasir.upm.edu.my/id/eprint/102658/ |