Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic...
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| Format: | Article |
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Persatuan Biologi Gunaan Malaysia,Malaysian Society of Applied Biology
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102259/ |
| _version_ | 1848863755977359360 |
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| author | Abd Majid, Noor Al Majidah Ishak, Muhammad Iqbal Murugapiran, Jagathis Wee Vanniar Abdul Aziz, Nor Azlina Basripuzi Nurul Hayyan |
| author_facet | Abd Majid, Noor Al Majidah Ishak, Muhammad Iqbal Murugapiran, Jagathis Wee Vanniar Abdul Aziz, Nor Azlina Basripuzi Nurul Hayyan |
| author_sort | Abd Majid, Noor Al Majidah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by Haemonchus contortus. Significant negative correlations were observed between FEC and PCV in control (r=-0.88, p<0.01), fenbendazole (r=-0.58, p<0.01) and ivermectin (r=-0.69, p<0.01) groups. Significant positive correlations were detected between FEC and PEC in control (r=0.95, p<0.01) and levamisole (r=0.56, p<0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep. |
| first_indexed | 2025-11-15T13:37:58Z |
| format | Article |
| id | upm-102259 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:37:58Z |
| publishDate | 2022 |
| publisher | Persatuan Biologi Gunaan Malaysia,Malaysian Society of Applied Biology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1022592023-07-10T02:04:20Z http://psasir.upm.edu.my/id/eprint/102259/ Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis Abd Majid, Noor Al Majidah Ishak, Muhammad Iqbal Murugapiran, Jagathis Wee Vanniar Abdul Aziz, Nor Azlina Basripuzi Nurul Hayyan Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by Haemonchus contortus. Significant negative correlations were observed between FEC and PCV in control (r=-0.88, p<0.01), fenbendazole (r=-0.58, p<0.01) and ivermectin (r=-0.69, p<0.01) groups. Significant positive correlations were detected between FEC and PEC in control (r=0.95, p<0.01) and levamisole (r=0.56, p<0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep. Persatuan Biologi Gunaan Malaysia,Malaysian Society of Applied Biology 2022-09-30 Article PeerReviewed Abd Majid, Noor Al Majidah and Ishak, Muhammad Iqbal and Murugapiran, Jagathis Wee Vanniar and Abdul Aziz, Nor Azlina and Basripuzi Nurul Hayyan (2022) Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis. Malaysian Applied Biology, 51 (3). 107 - 115. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/article/view/2260 10.55230/mabjournal.v51i3.2260 |
| spellingShingle | Abd Majid, Noor Al Majidah Ishak, Muhammad Iqbal Murugapiran, Jagathis Wee Vanniar Abdul Aziz, Nor Azlina Basripuzi Nurul Hayyan Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title | Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title_full | Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title_fullStr | Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title_full_unstemmed | Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title_short | Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| title_sort | multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis |
| url | http://psasir.upm.edu.my/id/eprint/102259/ http://psasir.upm.edu.my/id/eprint/102259/ http://psasir.upm.edu.my/id/eprint/102259/ |