Molecular dynamics revealed the effect of epoxy group on triglyceride digestion
The digestion behavior of epoxy triglyceride, the main cytotoxic product of deep-frying oil, remains unknown, which may affect its biosafety. In this study, epoxy triglyceride (EGT) and triglyceride (GT) were used to reveal the effect of epoxy group on digestion. Digestibility rate analysis showed t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Elsevier BV
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102228/ |
| _version_ | 1848863747934781440 |
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| author | Li, Xue Liu, Yan jun Nian, Binbin Cao, Xinyu Tan, Chin Ping Liu, Yuanfa Xu, Yongjiang |
| author_facet | Li, Xue Liu, Yan jun Nian, Binbin Cao, Xinyu Tan, Chin Ping Liu, Yuanfa Xu, Yongjiang |
| author_sort | Li, Xue |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The digestion behavior of epoxy triglyceride, the main cytotoxic product of deep-frying oil, remains unknown, which may affect its biosafety. In this study, epoxy triglyceride (EGT) and triglyceride (GT) were used to reveal the effect of epoxy group on digestion. Digestibility rate analysis showed that the free fatty acids release rate of EGT was slower. To clarify this phenomenon, binding ability with salt ions in digestive juice and particle size were also been studied. Cluster size analysis indicated that epoxy group increased triglyceride particle size, resulting in smaller contact area between EGT and lipase. Interface behaviors displayed EGT decreased binding ability with salt ions in digestive juice. Spectroscopic analysis showed EGT caused the red shift of lipase peak, indicating that epoxy group changed lipase structure. Molecular dynamics simulation suggested EGT leads to loosen lipase structure. In conclusion, this study highlights that epoxy group could weaken the triglyceride digestion. |
| first_indexed | 2025-11-15T13:37:50Z |
| format | Article |
| id | upm-102228 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:37:50Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1022282023-07-10T02:25:10Z http://psasir.upm.edu.my/id/eprint/102228/ Molecular dynamics revealed the effect of epoxy group on triglyceride digestion Li, Xue Liu, Yan jun Nian, Binbin Cao, Xinyu Tan, Chin Ping Liu, Yuanfa Xu, Yongjiang The digestion behavior of epoxy triglyceride, the main cytotoxic product of deep-frying oil, remains unknown, which may affect its biosafety. In this study, epoxy triglyceride (EGT) and triglyceride (GT) were used to reveal the effect of epoxy group on digestion. Digestibility rate analysis showed that the free fatty acids release rate of EGT was slower. To clarify this phenomenon, binding ability with salt ions in digestive juice and particle size were also been studied. Cluster size analysis indicated that epoxy group increased triglyceride particle size, resulting in smaller contact area between EGT and lipase. Interface behaviors displayed EGT decreased binding ability with salt ions in digestive juice. Spectroscopic analysis showed EGT caused the red shift of lipase peak, indicating that epoxy group changed lipase structure. Molecular dynamics simulation suggested EGT leads to loosen lipase structure. In conclusion, this study highlights that epoxy group could weaken the triglyceride digestion. Elsevier BV 2022 Article PeerReviewed Li, Xue and Liu, Yan jun and Nian, Binbin and Cao, Xinyu and Tan, Chin Ping and Liu, Yuanfa and Xu, Yongjiang (2022) Molecular dynamics revealed the effect of epoxy group on triglyceride digestion. Food Chemistry, 373 (Pt. B). art. no. 131285. pp. 1-7. ISSN 0308-8146 https://www.sciencedirect.com/science/article/pii/S0308814621022913#:~:text=Epoxy%20group%20increased%20the%20mean%20particle%20diameter%20of%20triglyceride.&text=Epoxy%20group%20decreased%20binding%20capacity,salt%20ions%20in%20digestive%20juice. 10.1016/j.foodchem.2021.131285 |
| spellingShingle | Li, Xue Liu, Yan jun Nian, Binbin Cao, Xinyu Tan, Chin Ping Liu, Yuanfa Xu, Yongjiang Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title | Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title_full | Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title_fullStr | Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title_full_unstemmed | Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title_short | Molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| title_sort | molecular dynamics revealed the effect of epoxy group on triglyceride digestion |
| url | http://psasir.upm.edu.my/id/eprint/102228/ http://psasir.upm.edu.my/id/eprint/102228/ http://psasir.upm.edu.my/id/eprint/102228/ |