Mechanisms and outcomes of metabolic surgery in type 2 diabetes
This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery...
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| Format: | Article |
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MDPI AG
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/102161/ |
| _version_ | 1848863731408175104 |
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| author | Mansor, Fazliana Nor Hanipah, Zubaidah |
| author_facet | Mansor, Fazliana Nor Hanipah, Zubaidah |
| author_sort | Mansor, Fazliana |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. |
| first_indexed | 2025-11-15T13:37:35Z |
| format | Article |
| id | upm-102161 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:37:35Z |
| publishDate | 2022 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1021612023-06-08T02:39:09Z http://psasir.upm.edu.my/id/eprint/102161/ Mechanisms and outcomes of metabolic surgery in type 2 diabetes Mansor, Fazliana Nor Hanipah, Zubaidah This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. MDPI AG 2022-11-17 Article PeerReviewed Mansor, Fazliana and Nor Hanipah, Zubaidah (2022) Mechanisms and outcomes of metabolic surgery in type 2 diabetes. Metabolites, 12 (11). art. no. 1134. pp. 1-5. ISSN 2218-1989 https://www.mdpi.com/2218-1989/12/11/1134 10.3390/metabo12111134 |
| spellingShingle | Mansor, Fazliana Nor Hanipah, Zubaidah Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title | Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title_full | Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title_fullStr | Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title_full_unstemmed | Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title_short | Mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| title_sort | mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| url | http://psasir.upm.edu.my/id/eprint/102161/ http://psasir.upm.edu.my/id/eprint/102161/ http://psasir.upm.edu.my/id/eprint/102161/ |