Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry
Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the ef...
| Main Authors: | , , , , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101966/ |
| _version_ | 1848863679605374976 |
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| author | Lee, Siew Siew Ling, King Hwa Tusimin, Maiza Subramaniam, Raman Rahim, Kartini Farah Loh, Su Peng |
| author_facet | Lee, Siew Siew Ling, King Hwa Tusimin, Maiza Subramaniam, Raman Rahim, Kartini Farah Loh, Su Peng |
| author_sort | Lee, Siew Siew |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the effect of maternal and neonatal vitamin D deficiency and vitamin D-related single nucleotide polymorphisms (SNPs) on neonatal birth anthropometry. This study aims to examine the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. This cross-sectional study included 217 mother–neonate dyads recruited from Hospital Serdang, Selangor, Malaysia, between 2015 and 2017. Plasma 25-hydroxyvitamin D (25OHD) concentration was measured in maternal and umbilical cord blood using ultra-high-performance liquid chromatography (UHPLC). Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) genotypes were determined using high-resolution melting (HRM). Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using restriction fragment length polymorphism. Our results showed that: (1) maternal vitamin D deficiency (25OHD < 30 nmol/L) was inversely associated with birth weight, head circumference and crown–heel length; (2) neonatal SNPs, VDR rs2228570 and GC rs4588, were significantly associated with birth weight and head circumference, respectively; and (3) a potential interaction was observed between maternal VDR rs2228570 with maternal vitamin D deficiency on head circumference. These findings suggest that the underlying mechanisms of vitamin D on foetal growth are likely to be localised in the maternal compartment, mediated through the placenta, rather than through cellular mechanisms within the foetus. Further large-scale studies are warranted to validate and extend these findings. |
| first_indexed | 2025-11-15T13:36:45Z |
| format | Article |
| id | upm-101966 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:36:45Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1019662023-06-16T20:15:10Z http://psasir.upm.edu.my/id/eprint/101966/ Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry Lee, Siew Siew Ling, King Hwa Tusimin, Maiza Subramaniam, Raman Rahim, Kartini Farah Loh, Su Peng Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the effect of maternal and neonatal vitamin D deficiency and vitamin D-related single nucleotide polymorphisms (SNPs) on neonatal birth anthropometry. This study aims to examine the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. This cross-sectional study included 217 mother–neonate dyads recruited from Hospital Serdang, Selangor, Malaysia, between 2015 and 2017. Plasma 25-hydroxyvitamin D (25OHD) concentration was measured in maternal and umbilical cord blood using ultra-high-performance liquid chromatography (UHPLC). Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) genotypes were determined using high-resolution melting (HRM). Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using restriction fragment length polymorphism. Our results showed that: (1) maternal vitamin D deficiency (25OHD < 30 nmol/L) was inversely associated with birth weight, head circumference and crown–heel length; (2) neonatal SNPs, VDR rs2228570 and GC rs4588, were significantly associated with birth weight and head circumference, respectively; and (3) a potential interaction was observed between maternal VDR rs2228570 with maternal vitamin D deficiency on head circumference. These findings suggest that the underlying mechanisms of vitamin D on foetal growth are likely to be localised in the maternal compartment, mediated through the placenta, rather than through cellular mechanisms within the foetus. Further large-scale studies are warranted to validate and extend these findings. Multidisciplinary Digital Publishing Institute 2022-01-27 Article PeerReviewed Lee, Siew Siew and Ling, King Hwa and Tusimin, Maiza and Subramaniam, Raman and Rahim, Kartini Farah and Loh, Su Peng (2022) Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry. Nutrients, 14 (3). art. no. 564. pp. 1-13. ISSN 2072-6643 https://www.mdpi.com/2072-6643/14/3/564 10.3390/nu14030564 |
| spellingShingle | Lee, Siew Siew Ling, King Hwa Tusimin, Maiza Subramaniam, Raman Rahim, Kartini Farah Loh, Su Peng Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title | Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title_full | Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title_fullStr | Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title_full_unstemmed | Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title_short | Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry |
| title_sort | interplay between maternal and neonatal vitamin d deficiency and vitamin-d-related gene polymorphism with neonatal birth anthropometry |
| url | http://psasir.upm.edu.my/id/eprint/101966/ http://psasir.upm.edu.my/id/eprint/101966/ http://psasir.upm.edu.my/id/eprint/101966/ |