Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury
Traumatic brain injury (TBI) could result in life-long disabilities and death. Though the mechanical insult causes primary injury, the secondary injury due to dysregulated responses following neuronal apoptosis and inflammation is often the cause for more detrimental consequences. Mesenchymal stroma...
| Main Authors: | , , , , , |
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| Format: | Article |
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Springer New York
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101848/ |
| _version_ | 1848863646718885888 |
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| author | Mot, Yee Yik Moses, Emmanuel Jairaj Mohd Yusoff, Narazah Ling, King Hwa Yong, Yoke Keong Tan, Jun Jie |
| author_facet | Mot, Yee Yik Moses, Emmanuel Jairaj Mohd Yusoff, Narazah Ling, King Hwa Yong, Yoke Keong Tan, Jun Jie |
| author_sort | Mot, Yee Yik |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Traumatic brain injury (TBI) could result in life-long disabilities and death. Though the mechanical insult causes primary injury, the secondary injury due to dysregulated responses following neuronal apoptosis and inflammation is often the cause for more detrimental consequences. Mesenchymal stromal cell (MSC) has been extensively investigated as the emerging therapeutic for TBI, and the functional properties are chiefly attributed to their secretome, especially the exosomes. Delivering these nanosize exosomes have shown to ameliorate post-traumatic injury and restore brain functions. Recent technology advances also allow engineering MSC-derived exosomes to carry specific biomolecules of interest to augment their therapeutic outcome. In this review, we discuss the pathophysiology of TBI and summarize the recent progress in the applications of MSCs-derived exosomes, the roles and the signalling mechanisms underlying the protective effects in the treatment of the TBI. |
| first_indexed | 2025-11-15T13:36:14Z |
| format | Article |
| id | upm-101848 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:36:14Z |
| publishDate | 2022 |
| publisher | Springer New York |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1018482023-09-22T23:38:48Z http://psasir.upm.edu.my/id/eprint/101848/ Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury Mot, Yee Yik Moses, Emmanuel Jairaj Mohd Yusoff, Narazah Ling, King Hwa Yong, Yoke Keong Tan, Jun Jie Traumatic brain injury (TBI) could result in life-long disabilities and death. Though the mechanical insult causes primary injury, the secondary injury due to dysregulated responses following neuronal apoptosis and inflammation is often the cause for more detrimental consequences. Mesenchymal stromal cell (MSC) has been extensively investigated as the emerging therapeutic for TBI, and the functional properties are chiefly attributed to their secretome, especially the exosomes. Delivering these nanosize exosomes have shown to ameliorate post-traumatic injury and restore brain functions. Recent technology advances also allow engineering MSC-derived exosomes to carry specific biomolecules of interest to augment their therapeutic outcome. In this review, we discuss the pathophysiology of TBI and summarize the recent progress in the applications of MSCs-derived exosomes, the roles and the signalling mechanisms underlying the protective effects in the treatment of the TBI. Springer New York 2022-02-01 Article PeerReviewed Mot, Yee Yik and Moses, Emmanuel Jairaj and Mohd Yusoff, Narazah and Ling, King Hwa and Yong, Yoke Keong and Tan, Jun Jie (2022) Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury. Cellular and Molecular Neurobiology, 43. pp. 469-489. ISSN 0272-4340; ESSN: 1573-6830 https://link.springer.com/article/10.1007/s10571-022-01201-y#citeas 10.1007/s10571-022-01201-y |
| spellingShingle | Mot, Yee Yik Moses, Emmanuel Jairaj Mohd Yusoff, Narazah Ling, King Hwa Yong, Yoke Keong Tan, Jun Jie Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title | Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title_full | Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title_fullStr | Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title_full_unstemmed | Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title_short | Mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| title_sort | mesenchymal stromal cells-derived exosome and the roles in the treatment of traumatic brain injury |
| url | http://psasir.upm.edu.my/id/eprint/101848/ http://psasir.upm.edu.my/id/eprint/101848/ http://psasir.upm.edu.my/id/eprint/101848/ |