Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition
Many of the therapeutic effects of plant extracts and bioactive compounds appear related to their immunomodulatory effects and impact on the host immune system. The immune response is desirable to mitigate established infections and, in the case of severe malaria, is a feasible approach to dealing w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Malaysian Society of Parasitology and Tropical Medicine
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/101840/ |
| _version_ | 1848863644658434048 |
|---|---|
| author | Hassan, Wan Rozianoor Mohd Ali, Amatul Hamizah Basir, Rusliza Embi, Noor Mohd Sidek, Hasidah |
| author_facet | Hassan, Wan Rozianoor Mohd Ali, Amatul Hamizah Basir, Rusliza Embi, Noor Mohd Sidek, Hasidah |
| author_sort | Hassan, Wan Rozianoor Mohd |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Many of the therapeutic effects of plant extracts and bioactive compounds appear related to their immunomodulatory effects and impact on the host immune system. The immune response is desirable to mitigate established infections and, in the case of severe malaria, is a feasible approach to dealing with the overwhelming cytokine response. Glycogen synthase kinase-3 (GSK3), a Ser/Thr kinase that is a central regulator of the cytokine response, is a promising antimalarial drug target. In this review, we discussed our ongoing research projects, which include assessing the antimalarial activities of medicinal plants and their bioactive compounds, immunomodulatory activities mediated by GSK3, and the potential inflammatory pathway involved in malarial infection. |
| first_indexed | 2025-11-15T13:36:12Z |
| format | Article |
| id | upm-101840 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:36:12Z |
| publishDate | 2022 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1018402024-02-29T08:32:29Z http://psasir.upm.edu.my/id/eprint/101840/ Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition Hassan, Wan Rozianoor Mohd Ali, Amatul Hamizah Basir, Rusliza Embi, Noor Mohd Sidek, Hasidah Many of the therapeutic effects of plant extracts and bioactive compounds appear related to their immunomodulatory effects and impact on the host immune system. The immune response is desirable to mitigate established infections and, in the case of severe malaria, is a feasible approach to dealing with the overwhelming cytokine response. Glycogen synthase kinase-3 (GSK3), a Ser/Thr kinase that is a central regulator of the cytokine response, is a promising antimalarial drug target. In this review, we discussed our ongoing research projects, which include assessing the antimalarial activities of medicinal plants and their bioactive compounds, immunomodulatory activities mediated by GSK3, and the potential inflammatory pathway involved in malarial infection. Malaysian Society of Parasitology and Tropical Medicine 2022 Article PeerReviewed Hassan, Wan Rozianoor Mohd and Ali, Amatul Hamizah and Basir, Rusliza and Embi, Noor and Mohd Sidek, Hasidah (2022) Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition. Tropical Biomedicine, 39 (3). 384 - 393. ISSN 2521-9855 https://msptm.org/vol-39-no-3-september/ 10.47665/tb.39.3.008 |
| spellingShingle | Hassan, Wan Rozianoor Mohd Ali, Amatul Hamizah Basir, Rusliza Embi, Noor Mohd Sidek, Hasidah Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title | Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title_full | Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title_fullStr | Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title_full_unstemmed | Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title_short | Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition |
| title_sort | medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (gsk3β) inhibition |
| url | http://psasir.upm.edu.my/id/eprint/101840/ http://psasir.upm.edu.my/id/eprint/101840/ http://psasir.upm.edu.my/id/eprint/101840/ |