Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Malaysian Medical Association
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101746/ |
| _version_ | 1848863621807865856 |
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| author | Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad |
| author_facet | Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad |
| author_sort | Mohd Amin, Amrina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated with mRNA vaccine (BTN162b2) and inactivated vaccine (CoronaVac). Materials and Methods: Plasma samples were collected prevaccination, 2 weeks and 6 months post-vaccination and tested for total immunoglobulin levels using ELISA method. Results: A small percentage of HCW (2.2%, 15/677) had elevated anti-S antibody levels in their pre-vaccination plasma samples (median 20.4, IQR 5.8), indicating that they were exposed to SARS-CoV-2 infection prior to vaccination. The mRNA vaccine significantly increased anti-S levels of both previously infected and uninfected individuals to saturation levels (median 21.88, IQR.0.88) at 2 weeks postsecond dose of the vaccine. At 6 months post-vaccination, the antibody levels appeared to be maintained among the recipients of the mRNA vaccine. However, at this time point, anti-S antibody levels were lower in individuals given inactivated vaccine (median 20.39, IQR 7.31, n=28), and interestingly, their antibody levels were similar to anti-S levels in pre-vaccination exposed individuals. Antibody levels were not different between the sexes. Conclusion: Anti-S levels differ in individuals given the different vaccines. While further study is required to determine the threshold level for protection against SARSCoV-2, individuals with low antibody levels may be considered for boosters. |
| first_indexed | 2025-11-15T13:35:50Z |
| format | Article |
| id | upm-101746 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:35:50Z |
| publishDate | 2022 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1017462024-04-30T02:37:39Z http://psasir.upm.edu.my/id/eprint/101746/ Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated with mRNA vaccine (BTN162b2) and inactivated vaccine (CoronaVac). Materials and Methods: Plasma samples were collected prevaccination, 2 weeks and 6 months post-vaccination and tested for total immunoglobulin levels using ELISA method. Results: A small percentage of HCW (2.2%, 15/677) had elevated anti-S antibody levels in their pre-vaccination plasma samples (median 20.4, IQR 5.8), indicating that they were exposed to SARS-CoV-2 infection prior to vaccination. The mRNA vaccine significantly increased anti-S levels of both previously infected and uninfected individuals to saturation levels (median 21.88, IQR.0.88) at 2 weeks postsecond dose of the vaccine. At 6 months post-vaccination, the antibody levels appeared to be maintained among the recipients of the mRNA vaccine. However, at this time point, anti-S antibody levels were lower in individuals given inactivated vaccine (median 20.39, IQR 7.31, n=28), and interestingly, their antibody levels were similar to anti-S levels in pre-vaccination exposed individuals. Antibody levels were not different between the sexes. Conclusion: Anti-S levels differ in individuals given the different vaccines. While further study is required to determine the threshold level for protection against SARSCoV-2, individuals with low antibody levels may be considered for boosters. Malaysian Medical Association 2022 Article PeerReviewed Mohd Amin, Amrina and Mukhtar, Shahidah and Razak, Sofiah Hanis and Che Mamat, Mirlia Suzila and Ramasamy, Thilakaveni and Cheah, Yoke Kqueen and Mahmud, Aidalina and Mohd Taib, Niazlin and Amin Nordin, Syafinaz and Abdullah, Maha and Mohd Isa, Muhammad (2022) Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia. Medical Journal of Malaysia, 78 (1). pp. 20-24. ISSN 0300-5283 https://www.e-mjm.org/2023/v78n1/index.html |
| spellingShingle | Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title | Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title_full | Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title_fullStr | Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title_full_unstemmed | Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title_short | Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia |
| title_sort | humoral response to sars-cov-2 vaccines among healthcare workers in a tertiary hospital in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/101746/ http://psasir.upm.edu.my/id/eprint/101746/ |