High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis
Objective: To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as a migraine prevention by conducting a systematic review and meta-analysis. Background: The efficacy of high-frequency repetitive transcranial magnetic stimulation...
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| Format: | Article |
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Sage Publications
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101706/ |
| _version_ | 1848863614263361536 |
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| author | Mohamad Safiai, Nabil Izzaatie Mohamad, Nur Afiqah Basri, Hamidon Inche Mat, Liyana Najwa Fan, Kee Hoo Abdul Rashid, Anna Misyail Yusof Khan, Abdul Hanif Khan Loh, Wei Chao Baharin, Janudin Fernandez, Aaron Samsudin, Intan Nureslyna Mohamed, Mohd Hazmi Ching, Siew Mooi Wan Sulaiman, Wan Aliaa |
| author_facet | Mohamad Safiai, Nabil Izzaatie Mohamad, Nur Afiqah Basri, Hamidon Inche Mat, Liyana Najwa Fan, Kee Hoo Abdul Rashid, Anna Misyail Yusof Khan, Abdul Hanif Khan Loh, Wei Chao Baharin, Janudin Fernandez, Aaron Samsudin, Intan Nureslyna Mohamed, Mohd Hazmi Ching, Siew Mooi Wan Sulaiman, Wan Aliaa |
| author_sort | Mohamad Safiai, Nabil Izzaatie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as a migraine prevention by conducting a systematic review and meta-analysis. Background: The efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as preventive migraine treatment remains debatable. Methods: PubMed, Scopus, CINAHL, CENTRAL, and BioMed Central databases were searched from their inception until December 2020. Randomised trials comparing high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex with sham for migraine prevention were included. The risk of bias was assessed using the Cochrane guidelines. Headache days, pain intensity, acute medication intake, and disability were extracted as study outcomes and the mean difference with a random-effects model was used to determine the effect size. Results: Meta-analysis revealed that high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex significantly reduced acute medication intake (Mean Difference = 9.78, p = 0.02, 95%CI: 1.60, 17.96, p = 0.02) and functional disability (Mean Difference = 8.00, p < 0.05, 95%CI: 4.21, 11.79). However, no differences were found in headache days and pain intensity reduction, although there was a slight trend favouring high-frequency repetitive transcranial magnetic stimulation. Conclusion: High-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex may be effective in reducing acute medication intake and disability. However, more studies are needed to strengthen this preliminary evidence. |
| first_indexed | 2025-11-15T13:35:43Z |
| format | Article |
| id | upm-101706 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:35:43Z |
| publishDate | 2022 |
| publisher | Sage Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1017062024-04-30T04:07:23Z http://psasir.upm.edu.my/id/eprint/101706/ High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis Mohamad Safiai, Nabil Izzaatie Mohamad, Nur Afiqah Basri, Hamidon Inche Mat, Liyana Najwa Fan, Kee Hoo Abdul Rashid, Anna Misyail Yusof Khan, Abdul Hanif Khan Loh, Wei Chao Baharin, Janudin Fernandez, Aaron Samsudin, Intan Nureslyna Mohamed, Mohd Hazmi Ching, Siew Mooi Wan Sulaiman, Wan Aliaa Objective: To evaluate the efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as a migraine prevention by conducting a systematic review and meta-analysis. Background: The efficacy of high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex as preventive migraine treatment remains debatable. Methods: PubMed, Scopus, CINAHL, CENTRAL, and BioMed Central databases were searched from their inception until December 2020. Randomised trials comparing high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex with sham for migraine prevention were included. The risk of bias was assessed using the Cochrane guidelines. Headache days, pain intensity, acute medication intake, and disability were extracted as study outcomes and the mean difference with a random-effects model was used to determine the effect size. Results: Meta-analysis revealed that high-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex significantly reduced acute medication intake (Mean Difference = 9.78, p = 0.02, 95%CI: 1.60, 17.96, p = 0.02) and functional disability (Mean Difference = 8.00, p < 0.05, 95%CI: 4.21, 11.79). However, no differences were found in headache days and pain intensity reduction, although there was a slight trend favouring high-frequency repetitive transcranial magnetic stimulation. Conclusion: High-frequency repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex may be effective in reducing acute medication intake and disability. However, more studies are needed to strengthen this preliminary evidence. Sage Publications 2022 Article PeerReviewed Mohamad Safiai, Nabil Izzaatie and Mohamad, Nur Afiqah and Basri, Hamidon and Inche Mat, Liyana Najwa and Fan, Kee Hoo and Abdul Rashid, Anna Misyail and Yusof Khan, Abdul Hanif Khan and Loh, Wei Chao and Baharin, Janudin and Fernandez, Aaron and Samsudin, Intan Nureslyna and Mohamed, Mohd Hazmi and Ching, Siew Mooi and Wan Sulaiman, Wan Aliaa (2022) High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis. Cephalalgia, 42 (10). 983- 1093. ISSN 0333-1024; ESSN: 1468-2982 https://journals.sagepub.com/doi/10.1177/03331024221092423 10.1177/03331024221092423 |
| spellingShingle | Mohamad Safiai, Nabil Izzaatie Mohamad, Nur Afiqah Basri, Hamidon Inche Mat, Liyana Najwa Fan, Kee Hoo Abdul Rashid, Anna Misyail Yusof Khan, Abdul Hanif Khan Loh, Wei Chao Baharin, Janudin Fernandez, Aaron Samsudin, Intan Nureslyna Mohamed, Mohd Hazmi Ching, Siew Mooi Wan Sulaiman, Wan Aliaa High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title | High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title_full | High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title_fullStr | High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title_full_unstemmed | High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title_short | High-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| title_sort | high-frequency repetitive transcranial magnetic stimulation at dorsolateral prefrontal cortex for migraine prevention: a systematic review and meta-analysis |
| url | http://psasir.upm.edu.my/id/eprint/101706/ http://psasir.upm.edu.my/id/eprint/101706/ http://psasir.upm.edu.my/id/eprint/101706/ |