Endolysins against Streptococci as an antibiotic alternative
Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively research...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Frontiers Research Foundation
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101248/ |
| _version_ | 1848863522618867712 |
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| author | Wong, Kuan Yee Megat Mazhar Khair, Megat Hamzah Song, Adelene Ai Lian Masarudin, Mas Jaffri Chong, Chou Min Lian, Lionel Aun In Yee, Michelle Mun Teo |
| author_facet | Wong, Kuan Yee Megat Mazhar Khair, Megat Hamzah Song, Adelene Ai Lian Masarudin, Mas Jaffri Chong, Chou Min Lian, Lionel Aun In Yee, Michelle Mun Teo |
| author_sort | Wong, Kuan Yee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins. Streptococcus spp. causes numerous infections, from the common strep throat to much more serious life-threatening infections such as pneumonia and meningitis. It is reported as a major crisis in various industries, causing systemic infections associated with high mortality and morbidity, as well as economic losses, especially in the agricultural industry. This review highlights the types of catalytic and cell wall-binding domains found in streptococcal endolysins and gives a comprehensive account of the lytic ability of both native and engineered streptococcal endolysins studied thus far, as well as its potential application across different industries. Finally, it gives an overview of the advantages and limitations of these enzyme-based antibiotics, which has caused the term enzybiotics to be conferred to it. |
| first_indexed | 2025-11-15T13:34:16Z |
| format | Article |
| id | upm-101248 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:34:16Z |
| publishDate | 2022 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1012482023-06-19T08:16:08Z http://psasir.upm.edu.my/id/eprint/101248/ Endolysins against Streptococci as an antibiotic alternative Wong, Kuan Yee Megat Mazhar Khair, Megat Hamzah Song, Adelene Ai Lian Masarudin, Mas Jaffri Chong, Chou Min Lian, Lionel Aun In Yee, Michelle Mun Teo Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins. Streptococcus spp. causes numerous infections, from the common strep throat to much more serious life-threatening infections such as pneumonia and meningitis. It is reported as a major crisis in various industries, causing systemic infections associated with high mortality and morbidity, as well as economic losses, especially in the agricultural industry. This review highlights the types of catalytic and cell wall-binding domains found in streptococcal endolysins and gives a comprehensive account of the lytic ability of both native and engineered streptococcal endolysins studied thus far, as well as its potential application across different industries. Finally, it gives an overview of the advantages and limitations of these enzyme-based antibiotics, which has caused the term enzybiotics to be conferred to it. Frontiers Research Foundation 2022-08-02 Article PeerReviewed Wong, Kuan Yee and Megat Mazhar Khair, Megat Hamzah and Song, Adelene Ai Lian and Masarudin, Mas Jaffri and Chong, Chou Min and Lian, Lionel Aun In and Yee, Michelle Mun Teo (2022) Endolysins against Streptococci as an antibiotic alternative. Frontiers in Microbiology, 13. pp. 1-14. ISSN 1664-302X https://www.frontiersin.org/articles/10.3389/fmicb.2022.935145/full 10.3389/fmicb.2022.935145 |
| spellingShingle | Wong, Kuan Yee Megat Mazhar Khair, Megat Hamzah Song, Adelene Ai Lian Masarudin, Mas Jaffri Chong, Chou Min Lian, Lionel Aun In Yee, Michelle Mun Teo Endolysins against Streptococci as an antibiotic alternative |
| title | Endolysins against Streptococci as an antibiotic alternative |
| title_full | Endolysins against Streptococci as an antibiotic alternative |
| title_fullStr | Endolysins against Streptococci as an antibiotic alternative |
| title_full_unstemmed | Endolysins against Streptococci as an antibiotic alternative |
| title_short | Endolysins against Streptococci as an antibiotic alternative |
| title_sort | endolysins against streptococci as an antibiotic alternative |
| url | http://psasir.upm.edu.my/id/eprint/101248/ http://psasir.upm.edu.my/id/eprint/101248/ http://psasir.upm.edu.my/id/eprint/101248/ |