Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials
Background: There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population. Material an...
| Main Authors: | , , , , , |
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| Format: | Article |
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BioMed Central
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/101152/ |
| _version_ | 1848863505437949952 |
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| author | Appannah, Geeta Djalainia, Shirin Pourrostami, Kumars Naderali, Ebrahim Khalil Khazdouz, Maryam Qorbani, Mostafa |
| author_facet | Appannah, Geeta Djalainia, Shirin Pourrostami, Kumars Naderali, Ebrahim Khalil Khazdouz, Maryam Qorbani, Mostafa |
| author_sort | Appannah, Geeta |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population. Material and method: We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI). Result: The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: − 0.14 mg/dl; 95% CI: − 0.25, − 0.02) and triglyceride (TG) (SMD: − 0.45 mg/dl; 95% CI: − 0.86, − 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months). Conclusion: The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number. |
| first_indexed | 2025-11-15T13:33:59Z |
| format | Article |
| id | upm-101152 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:33:59Z |
| publishDate | 2022 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1011522024-05-02T06:48:42Z http://psasir.upm.edu.my/id/eprint/101152/ Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials Appannah, Geeta Djalainia, Shirin Pourrostami, Kumars Naderali, Ebrahim Khalil Khazdouz, Maryam Qorbani, Mostafa Background: There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population. Material and method: We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI). Result: The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: − 0.14 mg/dl; 95% CI: − 0.25, − 0.02) and triglyceride (TG) (SMD: − 0.45 mg/dl; 95% CI: − 0.86, − 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months). Conclusion: The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number. BioMed Central 2022 Article PeerReviewed Appannah, Geeta and Djalainia, Shirin and Pourrostami, Kumars and Naderali, Ebrahim Khalil and Khazdouz, Maryam and Qorbani, Mostafa (2022) Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials. Diabetology & Metabolic Syndrome, 14 (88). pp. 1-15. ISSN 1758-5996 https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-022-00859-0 10.1186/s13098-022-00859-0 |
| spellingShingle | Appannah, Geeta Djalainia, Shirin Pourrostami, Kumars Naderali, Ebrahim Khalil Khazdouz, Maryam Qorbani, Mostafa Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title | Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title_full | Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title_fullStr | Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title_full_unstemmed | Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title_short | Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| title_sort | effect of vitamin d supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials |
| url | http://psasir.upm.edu.my/id/eprint/101152/ http://psasir.upm.edu.my/id/eprint/101152/ http://psasir.upm.edu.my/id/eprint/101152/ |