Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial
Background : In recent years, emerging evidence has highlighted the role of vitamin D as an iron absorption enhancer by suppressing hepcidin concentration, albeit with an unclear underlying mechanism. Dietary-based approach in improving iron status has been widely practised, however, there is a scar...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Public Library of Science PLOS
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/101151/ |
| _version_ | 1848863505176854528 |
|---|---|
| author | Ahmad Fuzi, Salma Faeza Loh, Su Peng Zalbahar @ Zabaha, Nurzalinda Ab. Manan, Norhafizah Mohamad Alwi, Muhammad Najib |
| author_facet | Ahmad Fuzi, Salma Faeza Loh, Su Peng Zalbahar @ Zabaha, Nurzalinda Ab. Manan, Norhafizah Mohamad Alwi, Muhammad Najib |
| author_sort | Ahmad Fuzi, Salma Faeza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background : In recent years, emerging evidence has highlighted the role of vitamin D as an iron absorption enhancer by suppressing hepcidin concentration, albeit with an unclear underlying mechanism. Dietary-based approach in improving iron status has been widely practised, however, there is a scarcity in randomized controlled trials (RCT) to elucidate the effect of vitamin D-fortified juice on iron status recovery. Therefore, this study aims to investigate the effect of an 8-week vitamin D3-fortified fruit juice supplementation on iron status indicators in childbearing-aged women with marginally low iron stores.
Methods : In a placebo-controlled, double-blind, RCT, a total of 120 women aged between 19–40 with serum ferritin < 20 μg/l and fulfilled the eligibility criteria will be randomized into consuming either vitamin D3-fortified fruit juices containing 4000 IU (100 mcg) (vitamin D) or placebo-fruit juices (placebo) daily for eight weeks. At every 4-week interval, 10 ml fasting blood sample, information on dietary habit and anthropometric measurement will be collected. A mixed model repeated-measures analysis of variance will be performed to determine the effect of the intervention and the interaction with time points for all iron and vitamin D status blood biomarkers.
Discussion : Vitamin D supplementation in food fortification as a novel iron absorption enhancer might be a future and relevant alternative management of iron deficiency as opposed to the oral iron therapy that has poor adherence. |
| first_indexed | 2025-11-15T13:33:59Z |
| format | Article |
| id | upm-101151 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:33:59Z |
| publishDate | 2022 |
| publisher | Public Library of Science PLOS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1011512023-05-23T07:38:54Z http://psasir.upm.edu.my/id/eprint/101151/ Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial Ahmad Fuzi, Salma Faeza Loh, Su Peng Zalbahar @ Zabaha, Nurzalinda Ab. Manan, Norhafizah Mohamad Alwi, Muhammad Najib Background : In recent years, emerging evidence has highlighted the role of vitamin D as an iron absorption enhancer by suppressing hepcidin concentration, albeit with an unclear underlying mechanism. Dietary-based approach in improving iron status has been widely practised, however, there is a scarcity in randomized controlled trials (RCT) to elucidate the effect of vitamin D-fortified juice on iron status recovery. Therefore, this study aims to investigate the effect of an 8-week vitamin D3-fortified fruit juice supplementation on iron status indicators in childbearing-aged women with marginally low iron stores. Methods : In a placebo-controlled, double-blind, RCT, a total of 120 women aged between 19–40 with serum ferritin < 20 μg/l and fulfilled the eligibility criteria will be randomized into consuming either vitamin D3-fortified fruit juices containing 4000 IU (100 mcg) (vitamin D) or placebo-fruit juices (placebo) daily for eight weeks. At every 4-week interval, 10 ml fasting blood sample, information on dietary habit and anthropometric measurement will be collected. A mixed model repeated-measures analysis of variance will be performed to determine the effect of the intervention and the interaction with time points for all iron and vitamin D status blood biomarkers. Discussion : Vitamin D supplementation in food fortification as a novel iron absorption enhancer might be a future and relevant alternative management of iron deficiency as opposed to the oral iron therapy that has poor adherence. Public Library of Science PLOS 2022-03-25 Article PeerReviewed Ahmad Fuzi, Salma Faeza and Loh, Su Peng and Zalbahar @ Zabaha, Nurzalinda and Ab. Manan, Norhafizah and Mohamad Alwi, Muhammad Najib (2022) Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS ONE, 17 (3). art. no. e0265772. pp. 1-14. ISSN 1932-6203 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0265772 10.1371/journal.pone.0265772 |
| spellingShingle | Ahmad Fuzi, Salma Faeza Loh, Su Peng Zalbahar @ Zabaha, Nurzalinda Ab. Manan, Norhafizah Mohamad Alwi, Muhammad Najib Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title | Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title_full | Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title_fullStr | Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title_full_unstemmed | Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title_short | Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| title_sort | effect of vitamin d3-fortified fruit juice supplementation of 4000 iu daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: protocol for an 8-week, parallel group, double-blind randomized controlled trial |
| url | http://psasir.upm.edu.my/id/eprint/101151/ http://psasir.upm.edu.my/id/eprint/101151/ http://psasir.upm.edu.my/id/eprint/101151/ |