Delaying emergence of resistance to KRAS inhibitors with adaptive therapy: “treatment-to-contain” instead of “treatment-to-cure”

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Delaying emergence of resistance to KRAS inhibitors with adaptive therapy: “treatment-to-contain” instead of “treatment-to-cure”

KRAS mutations are among the most common oncogenic abnormalities in cancer. Until recently, drug discovery pursuing KRAS did not produce therapeutic benefits for patients. Specific KRAS inhibitors, such as sotorasib and adagrasib, which bind covalently to codon 12 of substituted glycine to cysteine...

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Bibliographic Details
Main Authors:	Hamdi, Amir Imran Faisal, Stanslas, Johnson
Format:	Article
Published:	Tech Science Press 2022
Online Access:	http://psasir.upm.edu.my/id/eprint/100887/

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