Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression
Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and acti...
| Main Authors: | , , , , , |
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| Format: | Article |
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China Medical University
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100845/ |
| _version_ | 1848863429255757824 |
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| author | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Thean, Chor Leow Osman, Mohd Azuraidi Ibrahim, Kamariah Nik Abd Rahman, Nik Mohd Afizan |
| author_facet | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Thean, Chor Leow Osman, Mohd Azuraidi Ibrahim, Kamariah Nik Abd Rahman, Nik Mohd Afizan |
| author_sort | Zaidi, Noorzaileen Eileena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Nonetheless, two emerging hallmarks are being described: aberrant metabolic pathways and evasion of immune destruction. Changes in tumour cell metabolism are not restricted to tumour cells alone; the products of the altered metabolism have a direct impact on the activity of immune cells inside the tumour microenvironment, particularly tumour-associated macrophages (TAMs). The complicated process of cancer growth is orchestrated by metabolic changes dictating the tight mutual connection between these cells. Here, we discuss approaches to exploit the interaction of cancer cells' abnormal metabolic activity and TAMs. We also describe ways to exploit it by reprogramming fatty acid metabolism via TAMs |
| first_indexed | 2025-11-15T13:32:46Z |
| format | Article |
| id | upm-100845 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:32:46Z |
| publishDate | 2022 |
| publisher | China Medical University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1008452023-08-16T08:37:34Z http://psasir.upm.edu.my/id/eprint/100845/ Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Thean, Chor Leow Osman, Mohd Azuraidi Ibrahim, Kamariah Nik Abd Rahman, Nik Mohd Afizan Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Nonetheless, two emerging hallmarks are being described: aberrant metabolic pathways and evasion of immune destruction. Changes in tumour cell metabolism are not restricted to tumour cells alone; the products of the altered metabolism have a direct impact on the activity of immune cells inside the tumour microenvironment, particularly tumour-associated macrophages (TAMs). The complicated process of cancer growth is orchestrated by metabolic changes dictating the tight mutual connection between these cells. Here, we discuss approaches to exploit the interaction of cancer cells' abnormal metabolic activity and TAMs. We also describe ways to exploit it by reprogramming fatty acid metabolism via TAMs China Medical University 2022 Article PeerReviewed Zaidi, Noorzaileen Eileena and Shazali, Nur Aima Hafiza and Thean, Chor Leow and Osman, Mohd Azuraidi and Ibrahim, Kamariah and Nik Abd Rahman, Nik Mohd Afizan (2022) Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression. BioMedicine, 12 (4). art. no. 2. pp. 9-19. ISSN 2211-8039 https://www.biomedicinej.com/biomedicine/vol12/iss4/2/ 10.37796/2211-8039.1381 |
| spellingShingle | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Thean, Chor Leow Osman, Mohd Azuraidi Ibrahim, Kamariah Nik Abd Rahman, Nik Mohd Afizan Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title | Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title_full | Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title_fullStr | Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title_full_unstemmed | Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title_short | Crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| title_sort | crosstalk between fatty acid metabolism and tumour-associated macrophages in cancer progression |
| url | http://psasir.upm.edu.my/id/eprint/100845/ http://psasir.upm.edu.my/id/eprint/100845/ http://psasir.upm.edu.my/id/eprint/100845/ |