CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages
Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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MDPI
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100641/ |
| _version_ | 1848863376715808768 |
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| author | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Leow, Thean-Chor Osman, Mohd Azuraidi Ibrahim, Kamariah Cheng, Wan-Hee Lai, Kok-Song Nik Abd Rahman, Nik Mohd Afizan |
| author_facet | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Leow, Thean-Chor Osman, Mohd Azuraidi Ibrahim, Kamariah Cheng, Wan-Hee Lai, Kok-Song Nik Abd Rahman, Nik Mohd Afizan |
| author_sort | Zaidi, Noorzaileen Eileena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark the tumour survival and promotion functions, which allow the cancer cells to become invasive and initiate the metastatic cascade. Importantly, these interactions have been closely associated with metabolic reprogramming, which can modulate the differentiation and functions of immune cells and thus initiate the antitumour response. The purpose of this report is to review the CD36 receptor, a prominent cell receptor in metabolic activity specifically in fatty acid (FA) uptake, for the metabolic symbiosis of cancer–macrophage. In this review, we provide an update on metabolic communication between tumour cells and macrophages, as well as how the immunometabolism indirectly orchestrates the tumour metastasis. |
| first_indexed | 2025-11-15T13:31:56Z |
| format | Article |
| id | upm-100641 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:31:56Z |
| publishDate | 2022 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1006412023-09-21T07:12:12Z http://psasir.upm.edu.my/id/eprint/100641/ CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Leow, Thean-Chor Osman, Mohd Azuraidi Ibrahim, Kamariah Cheng, Wan-Hee Lai, Kok-Song Nik Abd Rahman, Nik Mohd Afizan Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark the tumour survival and promotion functions, which allow the cancer cells to become invasive and initiate the metastatic cascade. Importantly, these interactions have been closely associated with metabolic reprogramming, which can modulate the differentiation and functions of immune cells and thus initiate the antitumour response. The purpose of this report is to review the CD36 receptor, a prominent cell receptor in metabolic activity specifically in fatty acid (FA) uptake, for the metabolic symbiosis of cancer–macrophage. In this review, we provide an update on metabolic communication between tumour cells and macrophages, as well as how the immunometabolism indirectly orchestrates the tumour metastasis. MDPI 2022-11-10 Article PeerReviewed Zaidi, Noorzaileen Eileena and Shazali, Nur Aima Hafiza and Leow, Thean-Chor and Osman, Mohd Azuraidi and Ibrahim, Kamariah and Cheng, Wan-Hee and Lai, Kok-Song and Nik Abd Rahman, Nik Mohd Afizan (2022) CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages. Cells, 11 (22). art. no. 3556. pp. 1-15. ISSN 2073-4409 https://www.mdpi.com/2073-4409/11/22/3556 10.3390/cells11223556 |
| spellingShingle | Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Leow, Thean-Chor Osman, Mohd Azuraidi Ibrahim, Kamariah Cheng, Wan-Hee Lai, Kok-Song Nik Abd Rahman, Nik Mohd Afizan CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title | CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title_full | CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title_fullStr | CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title_full_unstemmed | CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title_short | CD36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| title_sort | cd36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages |
| url | http://psasir.upm.edu.my/id/eprint/100641/ http://psasir.upm.edu.my/id/eprint/100641/ http://psasir.upm.edu.my/id/eprint/100641/ |