Cancer-associated membrane protein as targeted therapy for bladder cancer
Bladder cancer (BC) recurrence is one of the primary clinical problems encountered by patients following chemotherapy. However, the mechanisms underlying their resistance to chemotherapy remain unclear. Alteration in the pattern of membrane proteins (MPs) is thought to be associated with this recurr...
| Main Authors: | , , , |
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| Format: | Article |
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MDPI
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/100582/ |
| _version_ | 1848863361518796800 |
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| author | Roslan, Adlina Sulaiman, Nurshahira Mohd Ghani, Khairul Asri Nurdin, Armania |
| author_facet | Roslan, Adlina Sulaiman, Nurshahira Mohd Ghani, Khairul Asri Nurdin, Armania |
| author_sort | Roslan, Adlina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Bladder cancer (BC) recurrence is one of the primary clinical problems encountered by patients following chemotherapy. However, the mechanisms underlying their resistance to chemotherapy remain unclear. Alteration in the pattern of membrane proteins (MPs) is thought to be associated with this recurrence outcome, often leading to cell dysfunction. Since MPs are found throughout the cell membrane, they have become the focus of attention for cancer diagnosis and treatment. Identifying specific and sensitive biomarkers for BC, therefore, requires a major collaborative effort. This review describes studies on membrane proteins as potential biomarkers to facilitate personalised medicine. It aims to introduce and discuss the types and significant functions of membrane proteins as potential biomarkers for future medicine. Other types of biomarkers such as DNA-, RNA- or metabolite-based biomarkers are not included in this review, but the focus is mainly on cell membrane surface protein-based biomarkers. |
| first_indexed | 2025-11-15T13:31:42Z |
| format | Article |
| id | upm-100582 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:31:42Z |
| publishDate | 2022 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1005822023-09-21T08:06:50Z http://psasir.upm.edu.my/id/eprint/100582/ Cancer-associated membrane protein as targeted therapy for bladder cancer Roslan, Adlina Sulaiman, Nurshahira Mohd Ghani, Khairul Asri Nurdin, Armania Bladder cancer (BC) recurrence is one of the primary clinical problems encountered by patients following chemotherapy. However, the mechanisms underlying their resistance to chemotherapy remain unclear. Alteration in the pattern of membrane proteins (MPs) is thought to be associated with this recurrence outcome, often leading to cell dysfunction. Since MPs are found throughout the cell membrane, they have become the focus of attention for cancer diagnosis and treatment. Identifying specific and sensitive biomarkers for BC, therefore, requires a major collaborative effort. This review describes studies on membrane proteins as potential biomarkers to facilitate personalised medicine. It aims to introduce and discuss the types and significant functions of membrane proteins as potential biomarkers for future medicine. Other types of biomarkers such as DNA-, RNA- or metabolite-based biomarkers are not included in this review, but the focus is mainly on cell membrane surface protein-based biomarkers. MDPI 2022-10-18 Article PeerReviewed Roslan, Adlina and Sulaiman, Nurshahira and Mohd Ghani, Khairul Asri and Nurdin, Armania (2022) Cancer-associated membrane protein as targeted therapy for bladder cancer. Pharmaceutics, 14 (10). art. no. 2218. pp. 1-19. ISSN 1999-4923 https://www.mdpi.com/1999-4923/14/10/2218 10.3390/pharmaceutics14102218 |
| spellingShingle | Roslan, Adlina Sulaiman, Nurshahira Mohd Ghani, Khairul Asri Nurdin, Armania Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title | Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title_full | Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title_fullStr | Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title_full_unstemmed | Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title_short | Cancer-associated membrane protein as targeted therapy for bladder cancer |
| title_sort | cancer-associated membrane protein as targeted therapy for bladder cancer |
| url | http://psasir.upm.edu.my/id/eprint/100582/ http://psasir.upm.edu.my/id/eprint/100582/ http://psasir.upm.edu.my/id/eprint/100582/ |