Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations
Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory,...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Dove Medical Press
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/100532/ |
| _version_ | 1848863348310933504 |
|---|---|
| author | Butnariu, Monica Quispe, Cristina Koirala, Niranjan Khadka, Sujan Salgado-Castillo, Carla Marina Muhammad Akram Rabia Anum Yeskaliyeva, Balakyz Cruz-Martins, Natália Martorell, Miquel Kumar, Manoj Bagiu, Radu Vasile Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Sharifi-Rad, Javad |
| author_facet | Butnariu, Monica Quispe, Cristina Koirala, Niranjan Khadka, Sujan Salgado-Castillo, Carla Marina Muhammad Akram Rabia Anum Yeskaliyeva, Balakyz Cruz-Martins, Natália Martorell, Miquel Kumar, Manoj Bagiu, Radu Vasile Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Sharifi-Rad, Javad |
| author_sort | Butnariu, Monica |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available. |
| first_indexed | 2025-11-15T13:31:29Z |
| format | Article |
| id | upm-100532 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:31:29Z |
| publishDate | 2022 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-1005322023-11-21T09:02:36Z http://psasir.upm.edu.my/id/eprint/100532/ Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations Butnariu, Monica Quispe, Cristina Koirala, Niranjan Khadka, Sujan Salgado-Castillo, Carla Marina Muhammad Akram Rabia Anum Yeskaliyeva, Balakyz Cruz-Martins, Natália Martorell, Miquel Kumar, Manoj Bagiu, Radu Vasile Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Sharifi-Rad, Javad Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available. Dove Medical Press 2022-08-15 Article PeerReviewed Butnariu, Monica and Quispe, Cristina and Koirala, Niranjan and Khadka, Sujan and Salgado-Castillo, Carla Marina and Muhammad Akram and Rabia Anum and Yeskaliyeva, Balakyz and Cruz-Martins, Natália and Martorell, Miquel and Kumar, Manoj and Bagiu, Radu Vasile and Abdull Razis, Ahmad Faizal and Sunusi, Usman and Muhammad Kamal, Ramla and Sharifi-Rad, Javad (2022) Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations. International Journal of Nanomedicine, 17. 3619 - 3632. ISSN 1176-9114 https://www.dovepress.com/bioactive-effects-of-curcumin-in-human-immunodeficiency-virus-infectio-peer-reviewed-fulltext-article-IJN 10.2147/IJN.S364501 |
| spellingShingle | Butnariu, Monica Quispe, Cristina Koirala, Niranjan Khadka, Sujan Salgado-Castillo, Carla Marina Muhammad Akram Rabia Anum Yeskaliyeva, Balakyz Cruz-Martins, Natália Martorell, Miquel Kumar, Manoj Bagiu, Radu Vasile Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Sharifi-Rad, Javad Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title | Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title_full | Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title_fullStr | Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title_full_unstemmed | Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title_short | Bioactive effects of Curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| title_sort | bioactive effects of curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations |
| url | http://psasir.upm.edu.my/id/eprint/100532/ http://psasir.upm.edu.my/id/eprint/100532/ http://psasir.upm.edu.my/id/eprint/100532/ |